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Factor VIII Is Synthesized in Human Endothelial Cells, Packaged in Weibel-Palade Bodies and Secreted Bound to ULVWF Strings

PloS one, 2015-10, Vol.10 (10), p.e0140740-e0140740

2015

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Thrombotic Microangiopathies

The New England journal of medicine, 2002-08, Vol.347 (8), p.589-600

Moake, Joel L

2002

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Acquired von Willebrand syndrome associated with left ventricular assist device

Blood, 2016-06, Vol.127 (25), p.3133-3141

2016

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Heat-inactivated Factor B inhibits alternative pathway fluid-phase activation and convertase formation on endothelial cell-secreted ultra-large von Willebrand factor strings

Scientific reports, 2023-04, Vol.13 (1), p.5764-5764, Article 5764

2023

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Thrombotic thrombocytopenic purpura

Nature reviews. Disease primers, 2017-04, Vol.3 (1), p.17020-17020, Article 17020

2017

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A new therapeutic strategy for atypical HUS

Blood, 2017-07, Vol.130 (3), p.243-244

Moake, Joel L.

2017

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Brain microvascular endothelial cells exhibit lower activation of the alternative complement pathway than glomerular microvascular endothelial cells

The Journal of biological chemistry, 2018-05, Vol.293 (19), p.7195-7208

2018

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Production and control of coagulation proteins for factor X activation in human endothelial cells and fibroblasts

Scientific reports, 2020-02, Vol.10 (1), p.2005-2005, Article 2005

2020

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TNF Regulates Essential Alternative Complement Pathway Components and Impairs Activation of Protein C in Human Glomerular Endothelial Cells

The Journal of immunology (1950), 2016-01, Vol.196 (2), p.832-845

2016

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Human endothelial cells and fibroblasts express and produce the coagulation proteins necessary for thrombin generation

Scientific reports, 2021-11, Vol.11 (1), p.21852-21852, Article 21852

2021

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Assembly and activation of alternative complement components on endothelial cell-anchored ultra-large von Willebrand factor links complement and hemostasis-thrombosis

PloS one, 2013-03, Vol.8 (3), p.e59372-e59372

2013

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N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice

The Journal of clinical investigation, 2011-02, Vol.121 (2), p.593-603

2011

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Effects of inflammatory cytokines on the release and cleavage of the endothelial cell–derived ultralarge von Willebrand factor multimers under flow

Blood, 2004-07, Vol.104 (1), p.100-106

2004

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Laminin Peptide-Immobilized Hydrogels Modulate Valve Endothelial Cell Hemostatic Regulation

PloS one, 2015-06, Vol.10 (6), p.e0130749-e0130749

2015

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Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage

Blood, 2009-12, Vol.114 (24), p.5102-5111

2009

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Thrombotic thrombocytopenia purpura (TTP) and other thrombotic microangiopathies

Best practice & research. Clinical haematology, 2009-12, Vol.22 (4), p.567-576

Moake, Joel, MD

2009

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Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy: results of a consensus process by an International Working Group

Haematologica (Roma), 2007-01, Vol.92 (1), p.95-100

2007

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ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions

Blood, 2002-12, Vol.100 (12), p.4033-4039

2002

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Regulatory components of the alternative complement pathway in endothelial cell cytoplasm, factor H and factor I, are not packaged in Weibel-Palade bodies

PloS one, 2015-03, Vol.10 (3), p.e0121994-e0121994

2015

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Thrombotic Microangiopathies: Multimers, Metalloprotease, and Beyond

Clinical and translational science, 2009-10, Vol.2 (5), p.366-373

Moake, Joel

2009

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Treatment of refractory thrombotic thrombocytopenic purpura with N-acetylcysteine: a case report

Transfusion (Philadelphia, Pa.), 2014-05, Vol.54 (5), p.1221-1224

2014

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Correlating Conformational Dynamics with the Von Willebrand Factor Reductase Activity of Factor H Using Single Molecule Force Measurements

The journal of physical chemistry. B, 2018-11, Vol.122 (47), p.10653-10658

2018

Volltextzugriff (PDF)

Human complement factor H is a reductase for large soluble von Willebrand factor multimers--brief report

Arteriosclerosis, thrombosis, and vascular biology, 2013-11, Vol.33 (11), p.2524-2528

2013

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Thrombotic microangiopathies and the linkage between von Willebrand factor and the alternative complement pathway

Seminars in thrombosis and hemostasis, 2014-07, Vol.40 (5), p.544-550

2014

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Recent advances in thrombotic thrombocytopenic purpura

Hematology, 2004, Vol.2004 (1), p.407-423

2004

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Factor VIII Is Synthesized in Human Endothelial Cells, Packaged in Weibel-Palade Bodies and Secreted Bound to ULVWF Strings

Thrombotic Microangiopathies

Acquired von Willebrand syndrome associated with left ventricular assist device

Heat-inactivated Factor B inhibits alternative pathway fluid-phase activation and convertase formation on endothelial cell-secreted ultra-large von Willebrand factor strings

Thrombotic thrombocytopenic purpura

A new therapeutic strategy for atypical HUS

Brain microvascular endothelial cells exhibit lower activation of the alternative complement pathway than glomerular microvascular endothelial cells

Production and control of coagulation proteins for factor X activation in human endothelial cells and fibroblasts

TNF Regulates Essential Alternative Complement Pathway Components and Impairs Activation of Protein C in Human Glomerular Endothelial Cells

Human endothelial cells and fibroblasts express and produce the coagulation proteins necessary for thrombin generation

Assembly and activation of alternative complement components on endothelial cell-anchored ultra-large von Willebrand factor links complement and hemostasis-thrombosis

N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice

Effects of inflammatory cytokines on the release and cleavage of the endothelial cell–derived ultralarge von Willebrand factor multimers under flow

Laminin Peptide-Immobilized Hydrogels Modulate Valve Endothelial Cell Hemostatic Regulation

Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage

Thrombotic thrombocytopenia purpura (TTP) and other thrombotic microangiopathies

Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy: results of a consensus process by an International Working Group

ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions

Regulatory components of the alternative complement pathway in endothelial cell cytoplasm, factor H and factor I, are not packaged in Weibel-Palade bodies

Thrombotic Microangiopathies: Multimers, Metalloprotease, and Beyond

Treatment of refractory thrombotic thrombocytopenic purpura with N-acetylcysteine: a case report

Correlating Conformational Dynamics with the Von Willebrand Factor Reductase Activity of Factor H Using Single Molecule Force Measurements

Human complement factor H is a reductase for large soluble von Willebrand factor multimers--brief report

Thrombotic microangiopathies and the linkage between von Willebrand factor and the alternative complement pathway

Recent advances in thrombotic thrombocytopenic purpura

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