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Mania is an extension of depression from the perspective of neuronal plasticity – evaluation of our hypothesis through the affective spectrum

Medical hypotheses, 2017-05, Vol.102, p.87-88

2017

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Neuronal plasticity in depressive or manic states – New assessment of our hypothesis: Mania is an extension of depression from the perspective of neuronal plasticity

Medical hypotheses, 2014-12, Vol.83 (6), p.845-846

2014

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Continuous path control of a 5-DOF parallel-serial hybrid robot

Journal of Mechanical Science and Technology, 2010, 24(1), , pp.47-50

2010

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Application of a multifractal analysis to study brain white matter abnormalities of schizophrenia on T2-weighted magnetic resonance imaging

Psychiatry research, 2009-03, Vol.171 (3), p.177-188

2009

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The co-occurrence of zinc deficiency and social isolation has the opposite effects on mood compared with either condition alone due to changes in the central norepinephrine system

Behavioural brain research, 2015-05, Vol.284, p.125-130

2015

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Region-specific causal mechanism in the effects of ammonia on cerebral glucose metabolism in the rat brain

Journal of Neural Transmission, 2013-03, Vol.120 (3), p.375-382

2013

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Opposite effects of SSRIs and tandospirone in the treatment of REM sleep behavior disorder

Sleep medicine, 2008-03, Vol.9 (3), p.317-319

2008

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Mania: Not the opposite of depression, but an extension? Neuronal plasticity and polarity

Medical hypotheses, 2013-08, Vol.81 (2), p.175-179

2013

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Effect of dietary zinc deficiency on ischemic vulnerability of the brain

Neuroscience letters, 2012-11, Vol.531 (1), p.10-13

2012

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Effects of antidepressants and mood stabilizers on serum levels of adiponectin

Neuro-endocrinology letters, 2012, Vol.33 (1), p.1-2

2012

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Multiaxial evaluation of the pathophysiology of mood disorder and therapeutic mechanisms of clinical drugs by neuronal plasticity and neuronal load

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2013-11, Vol.33 (5-6), p.231

2013

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A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication

Nature communications, 2021-01, Vol.12 (1), p.668-12, Article 668

2021

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Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib‐sensitive and ‐resistant multiple myeloma cells

Cancer science, 2019-10, Vol.110 (10), p.3275-3287

2019

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Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity

Scientific reports, 2020-06, Vol.10 (1), p.10664-10664, Article 10664

2020

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Mechanism of Darunavir (DRV)'s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance

mBio, 2018-03, Vol.9 (2)

2018

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Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir

Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (33), p.12234-12239

2014

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Seroprevalence of SARS-CoV-2 antibodies in a national hospital and affiliated facility after the second epidemic wave of Japan

The Journal of infection, 2021-08, Vol.83 (2), p.237-279

2021

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Design and Synthesis of Potent HIV‑1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure–Activity Studies and Biological and X‑ray Structural Studies

Journal of medicinal chemistry, 2018-11, Vol.61 (21), p.9722-9737

2018

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Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications

Antimicrobial agents and chemotherapy, 2019-07, Vol.63 (7)

2019

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GRL-079, a Novel HIV-1 Protease Inhibitor, Is Extremely Potent against Multidrug-Resistant HIV-1 Variants and Has a High Genetic Barrier against the Emergence of Resistant Variants

Antimicrobial agents and chemotherapy, 2018-05, Vol.62 (5)

2018

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Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV‑1 Protease Inhibitors: Design, Synthesis, Protein X‑ray Structural Studies, and Biological Evaluation

Journal of medicinal chemistry, 2016-07, Vol.59 (14), p.6826-6837

2016

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The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase

Cell chemical biology, 2018-10, Vol.25 (10), p.1268-1278.e3

2018

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Design and Development of Highly Potent HIV‑1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants

Journal of medicinal chemistry, 2017-05, Vol.60 (10), p.4267-4278

2017

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Mania is an extension of depression from the perspective of neuronal plasticity – evaluation of our hypothesis through the affective spectrum

Neuronal plasticity in depressive or manic states – New assessment of our hypothesis: Mania is an extension of depression from the perspective of neuronal plasticity

Continuous path control of a 5-DOF parallel-serial hybrid robot

Application of a multifractal analysis to study brain white matter abnormalities of schizophrenia on T2-weighted magnetic resonance imaging

The co-occurrence of zinc deficiency and social isolation has the opposite effects on mood compared with either condition alone due to changes in the central norepinephrine system

Region-specific causal mechanism in the effects of ammonia on cerebral glucose metabolism in the rat brain

Opposite effects of SSRIs and tandospirone in the treatment of REM sleep behavior disorder

Mania: Not the opposite of depression, but an extension? Neuronal plasticity and polarity

Effect of dietary zinc deficiency on ischemic vulnerability of the brain

Effects of antidepressants and mood stabilizers on serum levels of adiponectin

Multiaxial evaluation of the pathophysiology of mood disorder and therapeutic mechanisms of clinical drugs by neuronal plasticity and neuronal load

A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication

Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib‐sensitive and ‐resistant multiple myeloma cells

Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity

A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency

Mechanism of Darunavir (DRV)'s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance

Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir

Seroprevalence of SARS-CoV-2 antibodies in a national hospital and affiliated facility after the second epidemic wave of Japan

Design and Synthesis of Potent HIV‑1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure–Activity Studies and Biological and X‑ray Structural Studies

Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications

Identification of SARS-CoV-2 Mpro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2

GRL-079, a Novel HIV-1 Protease Inhibitor, Is Extremely Potent against Multidrug-Resistant HIV-1 Variants and Has a High Genetic Barrier against the Emergence of Resistant Variants

Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV‑1 Protease Inhibitors: Design, Synthesis, Protein X‑ray Structural Studies, and Biological Evaluation

The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase

Design and Development of Highly Potent HIV‑1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants

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