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Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

Pharmaceutical research, 2013-09, Vol.30 (9), p.2174-2187

2013

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Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

Drug metabolism reviews, 2012-02, Vol.44 (1), p.88-106

2012

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Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity

Toxicology and applied pharmacology, 2012-11, Vol.264 (3), p.387-394

2012

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The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

The Journal of clinical investigation, 2012-04, Vol.122 (4), p.1574-1583

2012

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Removal of Acetaminophen-Protein Adducts by Autophagy Protects Against Acetaminophen-Induced Liver Injury in Mice

Journal of hepatology, 2016-08, Vol.65 (2), p.354-362

2016

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Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients

Expert opinion on drug metabolism & toxicology, 2014-07, Vol.10 (7), p.1005-1017

2014

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Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model

Molecules (Basel, Switzerland), 2019-04, Vol.24 (9), p.1694

2019

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Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase

Toxicology and applied pharmacology, 2014-11, Vol.281 (1), p.58-66

2014

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Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen‐induced hepatocyte necrosis in mice

Hepatology (Baltimore, Md.), 2013-12, Vol.58 (6), p.2099-2108

2013

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Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans

Toxicology and applied pharmacology, 2014-03, Vol.275 (2), p.122-133

2014

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Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis

Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (33), p.12169-12174

2014

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Mechanisms of acetaminophen-induced cell death in primary human hepatocytes

Toxicology and applied pharmacology, 2014-09, Vol.279 (3), p.266-274

2014

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HepaRG Cells: A Human Model to Study Mechanisms of Acetaminophen Hepatotoxicity

Hepatology (Baltimore, Md.), 2011-03, Vol.53 (3), p.974-982

2011

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Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity

Food and chemical toxicology, 2017-10, Vol.108 (Pt A), p.339-350

2017

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Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity

Food and chemical toxicology, 2015-07, Vol.81, p.62-70

2015

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The past and present of serum aminotransferases and the future of liver injury biomarkers

EXCLI journal, 2016-01, Vol.15, p.817-828

McGill, Mitchell R

2016

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Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications

Toxicology and applied pharmacology, 2013-06, Vol.269 (3), p.240-249

2013

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Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury

Toxicological sciences, 2012-06, Vol.127 (2), p.438-450

2012

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Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes

Toxicology and applied pharmacology, 2015-12, Vol.289 (2), p.213-222

2015

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Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice

Toxicological sciences, 2017-02, Vol.155 (2), p.363-378

2017

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Bile Acid‐Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human Hepatocytes

Basic & clinical pharmacology & toxicology, 2016-02, Vol.118 (2), p.160-167

2016

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Critical review of resveratrol in xenobiotic-induced hepatotoxicity

Food and chemical toxicology, 2015-12, Vol.86, p.309-318

2015

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Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms

PLoS computational biology, 2020-06, Vol.16 (6), p.e1007622

2020

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The Evolution of Circulating Biomarkers for Use in Acetaminophen/Paracetamol-Induced Liver Injury in Humans: A Scoping Review

Livers, 2023-12, Vol.3 (4), p.569-596

2023

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Animal models of drug-induced liver injury

Biochimica et biophysica acta. Molecular basis of disease, 2019-05, Vol.1865 (5), p.1031-1039

2019

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Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

Removal of Acetaminophen-Protein Adducts by Autophagy Protects Against Acetaminophen-Induced Liver Injury in Mice

Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients

Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model

Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase

Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen‐induced hepatocyte necrosis in mice

Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans

Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis

Mechanisms of acetaminophen-induced cell death in primary human hepatocytes

HepaRG Cells: A Human Model to Study Mechanisms of Acetaminophen Hepatotoxicity

Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity

Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity

The past and present of serum aminotransferases and the future of liver injury biomarkers

Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications

Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury

Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes

Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice

Bile Acid‐Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human Hepatocytes

Critical review of resveratrol in xenobiotic-induced hepatotoxicity

Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms

The Evolution of Circulating Biomarkers for Use in Acetaminophen/Paracetamol-Induced Liver Injury in Humans: A Scoping Review

Animal models of drug-induced liver injury

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