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Targeting the orexin system for prescription opioid use disorder: Orexin-1 receptor blockade prevents oxycodone taking and seeking in rats

Neuropharmacology, 2020-03, Vol.164, p.107906-107906, Article 107906

2020

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Understanding the Role of Orexin Neuropeptides in Drug Addiction: Preclinical Studies and Translational Value

Frontiers in behavioral neuroscience, 2022-01, Vol.15, p.787595-787595

2022

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Orexin-A/Hypocretin-1 Mediates Cocaine-Seeking Behavior in the Posterior Paraventricular Nucleus of the Thalamus via Orexin/Hypocretin Receptor-2

The Journal of pharmacology and experimental therapeutics, 2016-11, Vol.359 (2), p.273

2016

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Blockade of Orexin Receptors in the Posterior Paraventricular Nucleus of the Thalamus Prevents Stress-Induced Reinstatement of Reward-Seeking Behavior in Rats With a History of Ethanol Dependence

Frontiers in integrative neuroscience, 2020-11, Vol.14, p.599710-599710

2020

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Drug Seeking and Relapse: New Evidence of a Role for Orexin and Dynorphin Co-transmission in the Paraventricular Nucleus of the Thalamus

Frontiers in neurology, 2018-08, Vol.9, p.720-720

2018

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Cocaine-Seeking Behavior Induced by Orexin A Administration in the Posterior Paraventricular Nucleus of the Thalamus Is Not Long-Lasting: Neuroadaptation of the Orexin System During Cocaine Abstinence

Frontiers in behavioral neuroscience, 2021-02, Vol.15, p.620868-620868

2021

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Cebranopadol Blocks the Escalation of Cocaine Intake and Conditioned Reinstatement of Cocaine Seeking in Rats

The Journal of pharmacology and experimental therapeutics, 2017-09, Vol.362 (3), p.378

2017

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Targeting the Orexin System for Prescription Opioid Use Disorder

Brain sciences, 2020-04, Vol.10 (4), p.226

2020

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Alternative use of suvorexant (Belsomra ® ) for the prevention of alcohol drinking and seeking in rats with a history of alcohol dependence

Frontiers in behavioral neuroscience, 2022-12, Vol.16, p.1085882-1085882

2022

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Suvorexant, an FDA-approved dual orexin receptor antagonist, reduces oxycodone self-administration and conditioned reinstatement in male and female rats

Frontiers in pharmacology, 2023-04, Vol.14, p.1127735-1127735

2023

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Dynorphin Counteracts Orexin in the Paraventricular Nucleus of the Thalamus: Cellular and Behavioral Evidence

Neuropsychopharmacology (New York, N.Y.), 2018-04, Vol.43 (5), p.1010-1020

2018

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Blockade of corticotropin-releasing factor receptor 1 in the central amygdala prevents cocaine-seeking behaviour induced by orexin-A administered to the posterior paraventricular nucleus of the thalamus in male rats

Journal of psychiatry & neuroscience, 2021-07, Vol.46 (4), p.E459-E471

2021

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Exploring Sex Differences in the Attenuation of Ethanol Drinking by Naltrexone in Dependent Rats During Early and Protracted Abstinence

Alcoholism, clinical and experimental research, 2018-12, Vol.42 (12), p.2466-2478

2018

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Sensitivity of Hypocretin System to Chronic Alcohol Exposure: A Human and Animal Study

Neuroscience, 2023-07, Vol.522, p.1-10

2023

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Daily treatment with the dual orexin receptor antagonist DORA-12 during oxycodone abstinence decreases oxycodone conditioned reinstatement

Neuropharmacology, 2023-11, Vol.239, p.109685-109685, Article 109685

2023

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ADX106772, an mGlu2 receptor positive allosteric modulator, selectively attenuates oxycodone taking and seeking

Neuropharmacology, 2023-11, Vol.238, p.109666-109666, Article 109666

2023

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Blockade of corticotropin-releasing factor-1 receptors in the infralimbic cortex prevents stress-induced reinstatement of alcohol seeking in male Wistar rats: Evidence of interaction between CRF1 and orexin receptor signaling

Neuropharmacology, 2022-06, Vol.210, p.109046-109046, Article 109046

2022

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Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats

Neuropsychopharmacology (New York, N.Y.), 2018-11, Vol.43 (12), p.2373-2382

2018

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The Amygdala Noradrenergic System Is Compromised With Alcohol Use Disorder

Biological psychiatry (1969), 2022-06, Vol.91 (12), p.1008-1018

2022

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The paraventricular nucleus of the thalamus is differentially recruited by stimuli conditioned to the availability of cocaine versus palatable food

Addiction biology, 2017-01, Vol.22 (1), p.70-77

2017

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Role of ionotropic glutamate receptors in the regulation of hippocampal norepinephrine output in vivo

Brain research, 2011-04, Vol.1386, p.41-49

2011

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Blockade of corticotropin-releasing factor-1 receptors in the infralimbic cortex prevents stress-induced reinstatement of alcohol seeking in male Wistar rats: Evidence of interaction between CRF 1 and orexin receptor signaling

Neuropharmacology, 2022-06, Vol.210, p.109046

2022

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Linking drug and food addiction via compulsive appetite

British journal of pharmacology, 2022-06, Vol.179 (11), p.2589-2609

2022

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Estrous Cycle-Dependent Changes in Basal and Ethanol-Induced Activity of Cortical Dopaminergic Neurons in the Rat

Neuropsychopharmacology (New York, N.Y.), 2007-04, Vol.32 (4), p.892-901

2007

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The paraventricular nucleus of the thalamus is recruited by both natural rewards and drugs of abuse: recent evidence of a pivotal role for orexin/hypocretin signaling in this thalamic nucleus in drug-seeking behavior

Frontiers in behavioral neuroscience, 2014-04, Vol.8, p.117-117

2014

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Targeting the orexin system for prescription opioid use disorder: Orexin-1 receptor blockade prevents oxycodone taking and seeking in rats

Understanding the Role of Orexin Neuropeptides in Drug Addiction: Preclinical Studies and Translational Value

Orexin-A/Hypocretin-1 Mediates Cocaine-Seeking Behavior in the Posterior Paraventricular Nucleus of the Thalamus via Orexin/Hypocretin Receptor-2

Blockade of Orexin Receptors in the Posterior Paraventricular Nucleus of the Thalamus Prevents Stress-Induced Reinstatement of Reward-Seeking Behavior in Rats With a History of Ethanol Dependence

Drug Seeking and Relapse: New Evidence of a Role for Orexin and Dynorphin Co-transmission in the Paraventricular Nucleus of the Thalamus

Cocaine-Seeking Behavior Induced by Orexin A Administration in the Posterior Paraventricular Nucleus of the Thalamus Is Not Long-Lasting: Neuroadaptation of the Orexin System During Cocaine Abstinence

Cebranopadol Blocks the Escalation of Cocaine Intake and Conditioned Reinstatement of Cocaine Seeking in Rats

Targeting the Orexin System for Prescription Opioid Use Disorder

Alternative use of suvorexant (Belsomra ® ) for the prevention of alcohol drinking and seeking in rats with a history of alcohol dependence

Suvorexant, an FDA-approved dual orexin receptor antagonist, reduces oxycodone self-administration and conditioned reinstatement in male and female rats

Dynorphin Counteracts Orexin in the Paraventricular Nucleus of the Thalamus: Cellular and Behavioral Evidence

Blockade of corticotropin-releasing factor receptor 1 in the central amygdala prevents cocaine-seeking behaviour induced by orexin-A administered to the posterior paraventricular nucleus of the thalamus in male rats

Exploring Sex Differences in the Attenuation of Ethanol Drinking by Naltrexone in Dependent Rats During Early and Protracted Abstinence

Sensitivity of Hypocretin System to Chronic Alcohol Exposure: A Human and Animal Study

Daily treatment with the dual orexin receptor antagonist DORA-12 during oxycodone abstinence decreases oxycodone conditioned reinstatement

ADX106772, an mGlu2 receptor positive allosteric modulator, selectively attenuates oxycodone taking and seeking

Blockade of corticotropin-releasing factor-1 receptors in the infralimbic cortex prevents stress-induced reinstatement of alcohol seeking in male Wistar rats: Evidence of interaction between CRF1 and orexin receptor signaling

Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats

The Amygdala Noradrenergic System Is Compromised With Alcohol Use Disorder

The paraventricular nucleus of the thalamus is differentially recruited by stimuli conditioned to the availability of cocaine versus palatable food

Role of ionotropic glutamate receptors in the regulation of hippocampal norepinephrine output in vivo

Blockade of corticotropin-releasing factor-1 receptors in the infralimbic cortex prevents stress-induced reinstatement of alcohol seeking in male Wistar rats: Evidence of interaction between CRF 1 and orexin receptor signaling

Linking drug and food addiction via compulsive appetite

Estrous Cycle-Dependent Changes in Basal and Ethanol-Induced Activity of Cortical Dopaminergic Neurons in the Rat

The paraventricular nucleus of the thalamus is recruited by both natural rewards and drugs of abuse: recent evidence of a pivotal role for orexin/hypocretin signaling in this thalamic nucleus in drug-seeking behavior

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