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Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs

Annals of the Rheumatic Diseases, 2003-06, Vol.62 (6), p.501-509

2003

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Biochemical basis of the effect of chondroitin sulphate on osteoarthritis articular tissues

Annals of the Rheumatic Diseases, 2008-06, Vol.67 (6), p.735-740

2008

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Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI

Annals of the rheumatic diseases, 2009-06, Vol.68 (6), p.938-947

2009

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PD-0200347, an α2δ ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCα dependent effect

Annals of the rheumatic diseases, 2006-05, Vol.65 (5), p.573-580

2006

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Computer-aided method for quantification of cartilage thickness and volume changes using MRI: validation study using a synthetic model

IEEE transactions on biomedical engineering, 2003-08, Vol.50 (8), p.978-988

2003

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Automatic Human Knee Cartilage Segmentation From 3-D Magnetic Resonance Images

IEEE transactions on biomedical engineering, 2010-11, Vol.57 (11), p.2699-2711

2010

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Magnetic resonance imaging can accurately assess the long-term progression of knee structural changes in experimental dog osteoarthritis

Annals of the rheumatic diseases, 2008-07, Vol.67 (7), p.926-932

2008

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Risk factors predictive of joint replacement in a 2-year multicentre clinical trial in knee osteoarthritis using MRI: results from over 6 years of observation

Annals of the rheumatic diseases, 2011-08, Vol.70 (8), p.1382-1388

2011

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Meniscal extrusion predicts increases in subchondral bone marrow lesions and bone cysts and expansion of subchondral bone in osteoarthritic knees

Rheumatology (Oxford, England), 2010-05, Vol.49 (5), p.997-1004

2010

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Decrease in serum level of matrix metalloproteinases is predictive of the disease-modifying effect of osteoarthritis drugs assessed by quantitative MRI in patients with knee osteoarthritis

Annals of the rheumatic diseases, 2010-12, Vol.69 (12), p.2095-2101

2010

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Chondrocyte death in experimental osteoarthritis is mediated by MEK 1/2 and p38 pathways: role of cyclooxygenase-2 and inducible nitric oxide synthase

Journal of rheumatology, 2001-11, Vol.28 (11), p.2509

2001

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Meniscal tear and extrusion are strongly associated with progression of symptomatic knee osteoarthritis as assessed by quantitative magnetic resonance imaging

Annals of the rheumatic diseases, 2005-04, Vol.64 (4), p.556-563

2005

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Association of polymorphisms in the peroxisome proliferator-activated receptor γ gene and osteoarthritis of the knee

Annals of the rheumatic diseases, 2006-10, Vol.65 (10), p.1394-1397

2006

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Transforming growth factor-beta induced collagenase-3 production in human osteoarthritic chondrocytes is triggered by Smad proteins: cooperation between activator protein-1 and PEA-3 binding sites

Journal of rheumatology, 2001-07, Vol.28 (7), p.1631

2001

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Modulation of TIMP-1 synthesis by antiinflammatory cytokines and prostaglandin E2 in interleukin 17 stimulated human monocytes/macrophages

Journal of rheumatology, 2001-04, Vol.28 (4), p.712

2001

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Intracellular localisation of galectin-3 has a protective role in chondrocyte survival

Annals of the rheumatic diseases, 2008-02, Vol.67 (2), p.175-181

2008

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Diacerein reduces the excess synthesis of bone remodeling factors by human osteoblast cells from osteoarthritic subchondral bone

Journal of rheumatology, 2001-04, Vol.28 (4), p.814

2001

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Galectin-3 surface expression on human adult chondrocytes: a potential substrate for collagenase-3

Annals of the rheumatic diseases, 2004-06, Vol.63 (6), p.636-643

2004

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Future therapeutics for osteoarthritis

Bone (New York, N.Y.), 2012-08, Vol.51 (2), p.297-311

2012

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Therapeutic targets in osteoarthritis: from today to tomorrow with new imaging technology

Annals of the rheumatic diseases, 2003-11, Vol.62 (suppl 2), p.ii79-ii82

2003

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Differential regulation of the bone morphogenic protein antagonist chordin in human normal and osteoarthritic chondrocytes

Annals of the rheumatic diseases, 2006-02, Vol.65 (2), p.261-264

2006

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Cyclooxygenase-2 and prostaglandins in articular tissues

Seminars in arthritis and rheumatism, 2003-12, Vol.33 (3), p.155-167

2003

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Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis

Annals of the rheumatic diseases, 2004-01, Vol.63 (1), p.78-83

2004

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Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis

Rheumatology (Oxford, England), 2009-12, Vol.48 (12), p.1482-1490

2009

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Excess of metalloproteases over tissue inhibitor of metalloprotease may contribute to cartilage degradation in osteoarthritis and rheumatoid arthritis

Laboratory investigation, 1994-06, Vol.70 (6), p.807

1994

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Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs

Biochemical basis of the effect of chondroitin sulphate on osteoarthritis articular tissues

Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI

PD-0200347, an α2δ ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCα dependent effect

Computer-aided method for quantification of cartilage thickness and volume changes using MRI: validation study using a synthetic model

Automatic Human Knee Cartilage Segmentation From 3-D Magnetic Resonance Images

Magnetic resonance imaging can accurately assess the long-term progression of knee structural changes in experimental dog osteoarthritis

Risk factors predictive of joint replacement in a 2-year multicentre clinical trial in knee osteoarthritis using MRI: results from over 6 years of observation

Meniscal extrusion predicts increases in subchondral bone marrow lesions and bone cysts and expansion of subchondral bone in osteoarthritic knees

Decrease in serum level of matrix metalloproteinases is predictive of the disease-modifying effect of osteoarthritis drugs assessed by quantitative MRI in patients with knee osteoarthritis

Chondrocyte death in experimental osteoarthritis is mediated by MEK 1/2 and p38 pathways: role of cyclooxygenase-2 and inducible nitric oxide synthase

Meniscal tear and extrusion are strongly associated with progression of symptomatic knee osteoarthritis as assessed by quantitative magnetic resonance imaging

Association of polymorphisms in the peroxisome proliferator-activated receptor γ gene and osteoarthritis of the knee

Transforming growth factor-beta induced collagenase-3 production in human osteoarthritic chondrocytes is triggered by Smad proteins: cooperation between activator protein-1 and PEA-3 binding sites

Modulation of TIMP-1 synthesis by antiinflammatory cytokines and prostaglandin E2 in interleukin 17 stimulated human monocytes/macrophages

Intracellular localisation of galectin-3 has a protective role in chondrocyte survival

Diacerein reduces the excess synthesis of bone remodeling factors by human osteoblast cells from osteoarthritic subchondral bone

Galectin-3 surface expression on human adult chondrocytes: a potential substrate for collagenase-3

Future therapeutics for osteoarthritis

Therapeutic targets in osteoarthritis: from today to tomorrow with new imaging technology

Differential regulation of the bone morphogenic protein antagonist chordin in human normal and osteoarthritic chondrocytes

Cyclooxygenase-2 and prostaglandins in articular tissues

Treatment with licofelone prevents abnormal subchondral bone cell metabolism in experimental dog osteoarthritis

Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis

Excess of metalloproteases over tissue inhibitor of metalloprotease may contribute to cartilage degradation in osteoarthritis and rheumatoid arthritis

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