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Romosozumab Improves Bone Mass and Strength While Maintaining Bone Quality in Ovariectomized Cynomolgus Monkeys

Journal of bone and mineral research, 2017-04, Vol.32 (4), p.788-801

2017

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Infant cynomolgus monkeys exposed to denosumab in utero exhibit an osteoclast-poor osteopetrotic-like skeletal phenotype at birth and in the early postnatal period

Bone (New York, N.Y.), 2014-07, Vol.64, p.314-325

2014

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Differential temporal effects of sclerostin antibody and parathyroid hormone on cancellous and cortical bone and quantitative differences in effects on the osteoblast lineage in young intact rats

Bone (New York, N.Y.), 2015-12, Vol.81, p.380-391

2015

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Carcinogenicity risk assessment of romosozumab: A review of scientific weight-of-evidence and findings in a rat lifetime pharmacology study

Regulatory toxicology and pharmacology, 2016-11, Vol.81, p.212-222

2016

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Investigation of maternal and fetal exposure to an IgG2 monoclonal antibody following biweekly intravaginal administration to cynomolgus monkeys throughout pregnancy

Reproductive toxicology (Elmsford, N.Y.), 2014-09, Vol.48, p.132-137

2014

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Reproductive toxicity of denosumab in cynomolgus monkeys

Reproductive toxicology (Elmsford, N.Y.), 2013-12, Vol.42, p.27-40

2013

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High Hematocrit Resulting from Administration of Erythropoiesis-stimulating Agents Is Not Fully Predictive of Mortality or Toxicities in Preclinical Species

Toxicologic pathology, 2014-04, Vol.42 (3), p.510-523

2014

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Dose-related Differences in the Pharmacodynamic and Toxicologic Response to a Novel Hyperglycosylated Analog of Recombinant Human Erythropoietin in Sprague-Dawley Rats with Similarly High Hematocrit

Toxicologic pathology, 2014-04, Vol.42 (3), p.524-539

2014

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Decreased osteoprogenitor proliferation precedes attenuation of cancellous bone formation in ovariectomized rats treated with sclerostin antibody

Bone Reports, 2018-06, Vol.8, p.90-94

2018

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Cytokines Associated with Increased Erythropoiesis in Sprague-Dawley Rats Administered a Novel Hyperglycosylated Analog of Recombinant Human Erythropoietin

Toxicologic pathology, 2014-04, Vol.42 (3), p.540-554

2014

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Differential time-dependent transcriptional changes in the osteoblast lineage in cortical bone associated with sclerostin antibody treatment in ovariectomized rats

Bone Reports, 2018-06, Vol.8, p.95-103

2018

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Nonclinical Safety Profile of Etelcalcetide, a Novel Peptide Calcimimetic for the Treatment of Secondary Hyperparathyroidism

International journal of toxicology, 2016-05, Vol.35 (3), p.294-308

2016

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Review of the Application of RNA Interference Technology in the Pharmaceutical Industry

Toxicologic pathology, 2007-04, Vol.35 (3), p.327-336

2007

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Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice

Molecular cancer therapeutics, 2008-03, Vol.7 (3), p.590-598

2008

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The International Nomenclature Project: An Update

Toxicologic pathology, 2009-08, Vol.37 (5), p.694-697

2009

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Global Recognition of Qualified Toxicologic Pathologists: Credential Review as a Potential Route for Recognizing the Proficiency of Pathologists Involved in Regulatory-type Nonclinical Studies

Toxicologic pathology, 2009-06, Vol.37 (4), p.553-561

2009

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Global Recognition of Qualified Toxicologic Pathologists: Where We Are Now and Where We Need to Go

Toxicologic pathology, 2008-07, Vol.36 (5), p.753-759

2008

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Transcriptional Profiling of Laser Capture Microdissected Subpopulations of the Osteoblast Lineage Provides Insight Into the Early Response to Sclerostin Antibody in Rats

Journal of bone and mineral research, 2015-08, Vol.30 (8), p.1457-1467

2015

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Global recognition of qualified toxicologic pathologists: Credential review as a potential route for recognizing the proficiency of pathologists involved in regulatory-type nonclinical studies

Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2010-07, Vol.62 (4), p.413-422

2010

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Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats

Bone (New York, N.Y.), 2016-03, Vol.84, p.148-159

2016

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Global Recognition of Qualified Toxicologic Pathologists: Credential Review as a Potential Route for Recognizing the Proficiency of Pathologists Involved in Regulatory-type Nonclinical Studies

Journal of Toxicologic Pathology, 2009, Vol.22(2), pp.143-152

2009

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Decreased bone remodeling and porosity are associated with improved bone strength in ovariectomized cynomolgus monkeys treated with denosumab, a fully human RANKL antibody

Bone (New York, N.Y.), 2011-08, Vol.49 (2), p.151-161

2011

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Denosumab, a fully human RANKL antibody, reduced bone turnover markers and increased trabecular and cortical bone mass, density, and strength in ovariectomized cynomolgus monkeys

Bone (New York, N.Y.), 2011-08, Vol.49 (2), p.162-173

2011

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Global Recognition of Qualified Toxicologic Pathologists: Where We Are Now and Where We Need to Go

Journal of Toxicologic Pathology, 2007, Vol.20(4), pp.267-272

2007

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Toxicologic Lesions Associated with Two Related Inhibitors of Oxidosqualene Cyclase in the Dog and Mouse

Toxicologic pathology, 2001-03, Vol.29 (2), p.174-179

2001

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Romosozumab Improves Bone Mass and Strength While Maintaining Bone Quality in Ovariectomized Cynomolgus Monkeys

Infant cynomolgus monkeys exposed to denosumab in utero exhibit an osteoclast-poor osteopetrotic-like skeletal phenotype at birth and in the early postnatal period

Differential temporal effects of sclerostin antibody and parathyroid hormone on cancellous and cortical bone and quantitative differences in effects on the osteoblast lineage in young intact rats

Carcinogenicity risk assessment of romosozumab: A review of scientific weight-of-evidence and findings in a rat lifetime pharmacology study

Investigation of maternal and fetal exposure to an IgG2 monoclonal antibody following biweekly intravaginal administration to cynomolgus monkeys throughout pregnancy

Reproductive toxicity of denosumab in cynomolgus monkeys

High Hematocrit Resulting from Administration of Erythropoiesis-stimulating Agents Is Not Fully Predictive of Mortality or Toxicities in Preclinical Species

Dose-related Differences in the Pharmacodynamic and Toxicologic Response to a Novel Hyperglycosylated Analog of Recombinant Human Erythropoietin in Sprague-Dawley Rats with Similarly High Hematocrit

Decreased osteoprogenitor proliferation precedes attenuation of cancellous bone formation in ovariectomized rats treated with sclerostin antibody

Cytokines Associated with Increased Erythropoiesis in Sprague-Dawley Rats Administered a Novel Hyperglycosylated Analog of Recombinant Human Erythropoietin

Differential time-dependent transcriptional changes in the osteoblast lineage in cortical bone associated with sclerostin antibody treatment in ovariectomized rats

Nonclinical Safety Profile of Etelcalcetide, a Novel Peptide Calcimimetic for the Treatment of Secondary Hyperparathyroidism

Review of the Application of RNA Interference Technology in the Pharmaceutical Industry

Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice

The International Nomenclature Project: An Update

Global Recognition of Qualified Toxicologic Pathologists: Credential Review as a Potential Route for Recognizing the Proficiency of Pathologists Involved in Regulatory-type Nonclinical Studies

Global Recognition of Qualified Toxicologic Pathologists: Where We Are Now and Where We Need to Go

Transcriptional Profiling of Laser Capture Microdissected Subpopulations of the Osteoblast Lineage Provides Insight Into the Early Response to Sclerostin Antibody in Rats

Global recognition of qualified toxicologic pathologists: Credential review as a potential route for recognizing the proficiency of pathologists involved in regulatory-type nonclinical studies

Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats

Global Recognition of Qualified Toxicologic Pathologists: Credential Review as a Potential Route for Recognizing the Proficiency of Pathologists Involved in Regulatory-type Nonclinical Studies

Decreased bone remodeling and porosity are associated with improved bone strength in ovariectomized cynomolgus monkeys treated with denosumab, a fully human RANKL antibody

Denosumab, a fully human RANKL antibody, reduced bone turnover markers and increased trabecular and cortical bone mass, density, and strength in ovariectomized cynomolgus monkeys

Global Recognition of Qualified Toxicologic Pathologists: Where We Are Now and Where We Need to Go

Toxicologic Lesions Associated with Two Related Inhibitors of Oxidosqualene Cyclase in the Dog and Mouse

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