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Apremilast, a cAMP phosphodiesterase‐4 inhibitor, demonstrates anti‐inflammatory activity in vitro and in a model of psoriasis

British journal of pharmacology, 2010-02, Vol.159 (4), p.842-855

2010

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Keynote review: Phosphodiesterase-4 as a therapeutic target

Drug discovery today, 2005-11, Vol.10 (22), p.1503-1519

2005

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Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

Trends in biochemical sciences (Amsterdam. Regular ed.), 2010-02, Vol.35 (2), p.91-100

Houslay, Miles D.

2010

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PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

Biochemical journal, 2003-02, Vol.370 (Pt 1), p.1-18

2003

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Phosphodiesterase-4 as a therapeutic target

Drug discovery today, 2005-11, Vol.10 (22), p.1503-1519

2005

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The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon‐like peptide‐1 release

British journal of pharmacology, 2009-06, Vol.157 (4), p.633-644

2009

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Phosphodiesterase inhibitors in the treatment of inflammatory diseases

Handbook of experimental pharmacology, 2011 (204), p.391

2011

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Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract

FEBS letters, 2005-06, Vol.579 (15), p.3264-3270

2005

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Fluorescence Resonance Energy Transfer–Based Analysis of cAMP Dynamics in Live Neonatal Rat Cardiac Myocytes Reveals Distinct Functions of Compartmentalized Phosphodiesterases

Circulation research, 2004-07, Vol.95 (1), p.67-75

2004

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DISC1 and PDE4B Are Interacting Genetic Factors in Schizophrenia That Regulate cAMP Signaling

Science (American Association for the Advancement of Science), 2005-11, Vol.310 (5751), p.1187-1191

2005

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Tailoring cAMP-signalling responses through isoform multiplicity

Trends in Biochemical Sciences, 1997-06, Vol.22 (6), p.217-224

1997

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The RACK1 scaffold protein: a dynamic cog in cell response mechanisms

Molecular pharmacology, 2002-12, Vol.62 (6), p.1261-1273

2002

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Compartmentalized Phosphodiesterase-2 Activity Blunts β-Adrenergic Cardiac Inotropy via an NO/cGMP-Dependent Pathway

Circulation research, 2006-02, Vol.98 (2), p.226-234

2006

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Phosphodiesterases in the central nervous system: implications in mood and cognitive disorders

Handbook of experimental pharmacology, 2011 (204), p.447

2011

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β-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates β-adrenoceptor switching from Gs to Gi

Proceedings of the National Academy of Sciences - PNAS, 2003-02, Vol.100 (3), p.940-945

2003

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Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes

Current opinion in cell biology, 2005-04, Vol.17 (2), p.129-134

2005

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Cell-type specific integration of cross-talk between extracellular signal-regulated kinase and cAMP signaling

Molecular pharmacology, 2000-10, Vol.58 (4), p.659-668

2000

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Phosphodiesterase inhibitors: factors that influence potency, selectivity, and action

Handbook of experimental pharmacology, 2011 (204), p.47

2011

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mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module

The EMBO journal, 2001-04, Vol.20 (8), p.1921-1930

2001

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Targeting of Cyclic AMP Degradation to$\beta_{2}-Adrenergic$Receptors by$\beta-Arrestins

Science (American Association for the Advancement of Science), 2002-10, Vol.298 (5594), p.834-836

2002

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Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A‐mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)

British journal of pharmacology, 2002-06, Vol.136 (3), p.421-433

2002

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Attenuation of the Activity of the cAMP-specific Phosphodiesterase PDE4A5 by Interaction with the Immunophilin XAP2

The Journal of biological chemistry, 2003-08, Vol.278 (35), p.33351-33363

2003

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The RACK1 Signaling Scaffold Protein Selectively Interacts with the cAMP-specific Phosphodiesterase PDE4D5 Isoform

The Journal of biological chemistry, 1999-05, Vol.274 (21), p.14909-14917

1999

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Phosphodiesterase inhibitors: history of pharmacology

Handbook of experimental pharmacology, 2011 (204), p.1

2011

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Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cells

Biochemical journal, 2000-04, Vol.347 (Pt 2), p.571-578

2000

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Apremilast, a cAMP phosphodiesterase‐4 inhibitor, demonstrates anti‐inflammatory activity in vitro and in a model of psoriasis

Keynote review: Phosphodiesterase-4 as a therapeutic target

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

Phosphodiesterase-4 as a therapeutic target

The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon‐like peptide‐1 release

Phosphodiesterase inhibitors in the treatment of inflammatory diseases

Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract

Fluorescence Resonance Energy Transfer–Based Analysis of cAMP Dynamics in Live Neonatal Rat Cardiac Myocytes Reveals Distinct Functions of Compartmentalized Phosphodiesterases

DISC1 and PDE4B Are Interacting Genetic Factors in Schizophrenia That Regulate cAMP Signaling

Tailoring cAMP-signalling responses through isoform multiplicity

The RACK1 scaffold protein: a dynamic cog in cell response mechanisms

Compartmentalized Phosphodiesterase-2 Activity Blunts β-Adrenergic Cardiac Inotropy via an NO/cGMP-Dependent Pathway

Phosphodiesterases in the central nervous system: implications in mood and cognitive disorders

β-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates β-adrenoceptor switching from Gs to Gi

Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes

Cell-type specific integration of cross-talk between extracellular signal-regulated kinase and cAMP signaling

Phosphodiesterase inhibitors: factors that influence potency, selectivity, and action

mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module

Targeting of Cyclic AMP Degradation to$\beta_{2}-Adrenergic$Receptors by$\beta-Arrestins

Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A‐mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)

Attenuation of the Activity of the cAMP-specific Phosphodiesterase PDE4A5 by Interaction with the Immunophilin XAP2

The RACK1 Signaling Scaffold Protein Selectively Interacts with the cAMP-specific Phosphodiesterase PDE4D5 Isoform

Phosphodiesterase inhibitors: history of pharmacology

Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cells

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