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Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases

Journal of medicinal chemistry, 2019-09, Vol.62 (17), p.7589-7602

2019

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Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors

Chemical reviews, 2016-06, Vol.116 (11), p.6707-6741

2016

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Selective α7 nicotinic receptor agonists and positive allosteric modulators for the treatment of schizophrenia - a review

Expert opinion on investigational drugs, 2020-06, Vol.29 (6), p.603-610

2020

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Return of D4 Dopamine Receptor Antagonists in Drug Discovery

Journal of medicinal chemistry, 2017-09, Vol.60 (17), p.7233-7243

2017

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Return of D 4 Dopamine Receptor Antagonists in Drug Discovery

Journal of medicinal chemistry, 2017-09, Vol.60 (17), p.7233

2017

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DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells

PloS one, 2012-07, Vol.7 (7), p.e41627

2012

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Use of ECT in Autism Spectrum Disorder and/or Intellectual Disability: A Single Site Retrospective Analysis

Journal of autism and developmental disorders, 2024-03, Vol.54 (3), p.963-982

2024

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A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models

Science (American Association for the Advancement of Science), 2017-12, Vol.358 (6368), p.1332-1336

2017

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Novel inhibitors of the renal inward rectifier potassium channel of the mosquito vector Aedes aegypti

Future medicinal chemistry, 2021-11, Vol.13 (22), p.2015

2021

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Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases: Miniperspective

Journal of medicinal chemistry, 2019-09, Vol.62 (17), p.7589-7602

2019

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Validation of an improved scale for rating l -DOPA-induced dyskinesia in the mouse and effects of specific dopamine receptor antagonists

Neurobiology of disease, 2016-12, Vol.96, p.156-170

2016

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Inhibition of the TRPC5 ion channel protects the kidney filter

The Journal of clinical investigation, 2013-12, Vol.123 (12), p.5298-5309

2013

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Inhibitors of the bone morphogenetic protein (BMP) signaling pathway: a patent review (2008-2015)

Expert opinion on therapeutic patents, 2016-10, Vol.26 (10), p.1115-1128

Hopkins, Corey R.

2016

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Discovery and characterization of benzyloxy piperidine based dopamine 4 receptor antagonists

Bioorganic & medicinal chemistry letters, 2022-04, Vol.61, p.128615-128615, Article 128615

2022

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Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903

Bioorganic & medicinal chemistry letters, 2019-01, Vol.29 (2), p.155-159

2019

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LJ000328, a novel ALK2/3 kinase inhibitor, represses hepcidin and significantly improves the phenotype of IRIDA

Haematologica (Roma), 2020-08, Vol.105 (8), p.e385-e388

2020

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Is There a Path Forward for mGlu2 Positive Allosteric Modulators for the Treatment of Schizophrenia?

ACS chemical neuroscience, 2013-02, Vol.4 (2), p.211-213

Hopkins, Corey R

2013

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Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992

Molecular pharmacology, 2018-08, Vol.94 (2), p.926-937

2018

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Eliciting renal failure in mosquitoes with a small-molecule inhibitor of inward-rectifying potassium channels

PloS one, 2013-05, Vol.8 (5), p.e64905

2013

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Discovery of Small Molecule Renal Outer Medullary Potassium (ROMK) Channel Inhibitors: A Brief History of Medicinal Chemistry Approaches To Develop Novel Diuretic Therapeutics

Journal of medicinal chemistry, 2019-10, Vol.62 (19), p.8682-8694

2019

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Discovery, synthesis and biological evaluation of a series of N-(phenylcarbamothioyl)-2-napthamides as inhibitors of Claudin-1

Bioorganic & medicinal chemistry, 2023-09, Vol.92, p.117416-117416, Article 117416

2023

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PIK3C3 Inhibition Promotes Sensitivity to Colon Cancer Therapy by Inhibiting Cancer Stem Cells

Cancers, 2021-04, Vol.13 (9), p.2168

2021

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Is there a path forward for mGlu(2) positive allosteric modulators for the treatment of schizophrenia?

ACS chemical neuroscience, 2013-02, Vol.4 (2), p.211-213

Hopkins, Corey R

2013

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“Molecular Switches” on mGluR Allosteric Ligands That Modulate Modes of Pharmacology

Biochemistry (Easton), 2011-04, Vol.50 (13), p.2403-2410

2011

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Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels

The Journal of biological chemistry, 2011-09, Vol.286 (38), p.33436-33446

2011

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Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases

Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors

Selective α7 nicotinic receptor agonists and positive allosteric modulators for the treatment of schizophrenia - a review

Return of D4 Dopamine Receptor Antagonists in Drug Discovery

Return of D 4 Dopamine Receptor Antagonists in Drug Discovery

DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells

Use of ECT in Autism Spectrum Disorder and/or Intellectual Disability: A Single Site Retrospective Analysis

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models

Novel inhibitors of the renal inward rectifier potassium channel of the mosquito vector Aedes aegypti

Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases: Miniperspective

Validation of an improved scale for rating l -DOPA-induced dyskinesia in the mouse and effects of specific dopamine receptor antagonists

Inhibition of the TRPC5 ion channel protects the kidney filter

Inhibitors of the bone morphogenetic protein (BMP) signaling pathway: a patent review (2008-2015)

Discovery and characterization of benzyloxy piperidine based dopamine 4 receptor antagonists

Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903

LJ000328, a novel ALK2/3 kinase inhibitor, represses hepcidin and significantly improves the phenotype of IRIDA

Is There a Path Forward for mGlu2 Positive Allosteric Modulators for the Treatment of Schizophrenia?

Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992

Eliciting renal failure in mosquitoes with a small-molecule inhibitor of inward-rectifying potassium channels

Discovery of Small Molecule Renal Outer Medullary Potassium (ROMK) Channel Inhibitors: A Brief History of Medicinal Chemistry Approaches To Develop Novel Diuretic Therapeutics

Discovery, synthesis and biological evaluation of a series of N-(phenylcarbamothioyl)-2-napthamides as inhibitors of Claudin-1

PIK3C3 Inhibition Promotes Sensitivity to Colon Cancer Therapy by Inhibiting Cancer Stem Cells

Is there a path forward for mGlu(2) positive allosteric modulators for the treatment of schizophrenia?

“Molecular Switches” on mGluR Allosteric Ligands That Modulate Modes of Pharmacology

Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels

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