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Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond

Nature reviews. Cancer, 2014-07, Vol.14 (7), p.455

2014

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K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling

Cell, 2015-11, Vol.163 (5), p.1237-1251

2015

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KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis

Proceedings of the National Academy of Sciences - PNAS, 2019-10, Vol.116 (44), p.22122-22131

2019

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Crosstalk Between Vascular Endothelial Growth Factor, Notch, and Transforming Growth Factor-β in Vascular Morphogenesis

Circulation research, 2008-03, Vol.102 (6), p.637-652

2008

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Transcriptome-wide characterization of the eIF4A signature highlights plasticity in translation regulation

Genome biology, 2014-01, Vol.15 (10), p.476-476, Article 476

2014

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TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype

Blood, 2008-05, Vol.111 (10), p.4997-5007

2008

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Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit

Molecular cell, 2016-12, Vol.64 (5), p.875-887

2016

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RAF Inhibitors Activate the MAPK Pathway by Relieving Inhibitory Autophosphorylation

Cancer cell, 2013-05, Vol.23 (5), p.594-602

2013

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Efforts to Develop KRAS Inhibitors

Cold Spring Harbor perspectives in medicine, 2018-07, Vol.8 (7), p.a031864

Holderfield, Matthew

2018

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Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions

Scientific reports, 2015-11, Vol.5 (1), p.15916-15916, Article 15916

2015

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Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis

The FASEB journal, 2005-06, Vol.19 (8), p.1027-1029

2005

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Label-Free Time-Gated Luminescent Detection Method for the Nucleotides with Varying Phosphate Content

Sensors (Basel, Switzerland), 2018-11, Vol.18 (11), p.3989

2018

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Interferon-induced transmembrane protein 1 regulates endothelial lumen formation during angiogenesis

Arteriosclerosis, thrombosis, and vascular biology, 2014-05, Vol.34 (5), p.1011

2014

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Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling

Cell reports methods, 2021-07, Vol.1 (3), p.100015, Article 100015

2021

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Abstract 1365: Sensitivity of oncogenic KRAS to adenosine triphosphate suppression

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.1365-1365

2017

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Abstract B03: Biologic and biochemical interactions of NF1 GAP on KRAS G13x mutations

Molecular cancer research, 2020-05, Vol.18 (5_Supplement), p.B03-B03

2020

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HESR1/CHF2 suppresses VEGFR2 transcription independent of binding to E-boxes

Biochemical and biophysical research communications, 2006-08, Vol.346 (3), p.637-648

2006

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Abstract B18: Clostridium perfringens lethal toxin specifically targets RAS and disrupts RAS signaling pathway

Molecular cancer research, 2020-05, Vol.18 (5_Supplement), p.B18-B18

2020

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Homogeneous Dual-Parametric-Coupled Assay for Simultaneous Nucleotide Exchange and KRAS/RAF-RBD Interaction Monitoring

Analytical chemistry (Washington), 2020-04, Vol.92 (7), p.4971-4979

2020

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New weapons to penetrate the armor: Novel reagents and assays developed at the NCI RAS Initiative to enable discovery of RAS therapeutics

Seminars in cancer biology, 2019-02, Vol.54, p.174-182

2019

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RAS signaling: Divide and conquer

Nature chemical biology, 2016-12, Vol.13 (1), p.7

2016

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KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis

Proceedings of the National Academy of Sciences - PNAS, 2019-10, Vol.116 (44)

2019

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The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through an atypical mechanism to disrupt Ras-ERK signaling

Science signaling, 2018-10, Vol.11 (550)

2018

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Abstract 2147: Correlating RAS oncogenic allele dependence with drug sensitivity

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.2147-2147

2015

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Abstract B08: ETC inhibitors alter oncogenic KRAS signal transduction

Molecular cancer research, 2020-05, Vol.18 (5_Supplement), p.B08-B08

2020

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Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond

K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling

KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis

Crosstalk Between Vascular Endothelial Growth Factor, Notch, and Transforming Growth Factor-β in Vascular Morphogenesis

Transcriptome-wide characterization of the eIF4A signature highlights plasticity in translation regulation

TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype

Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit

RAF Inhibitors Activate the MAPK Pathway by Relieving Inhibitory Autophosphorylation

Efforts to Develop KRAS Inhibitors

Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions

Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis

Label-Free Time-Gated Luminescent Detection Method for the Nucleotides with Varying Phosphate Content

Interferon-induced transmembrane protein 1 regulates endothelial lumen formation during angiogenesis

Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling

Abstract 1365: Sensitivity of oncogenic KRAS to adenosine triphosphate suppression

Abstract B03: Biologic and biochemical interactions of NF1 GAP on KRAS G13x mutations

HESR1/CHF2 suppresses VEGFR2 transcription independent of binding to E-boxes

Abstract B18: Clostridium perfringens lethal toxin specifically targets RAS and disrupts RAS signaling pathway

Homogeneous Dual-Parametric-Coupled Assay for Simultaneous Nucleotide Exchange and KRAS/RAF-RBD Interaction Monitoring

New weapons to penetrate the armor: Novel reagents and assays developed at the NCI RAS Initiative to enable discovery of RAS therapeutics

RAS signaling: Divide and conquer

KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis

The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through an atypical mechanism to disrupt Ras-ERK signaling

Abstract 2147: Correlating RAS oncogenic allele dependence with drug sensitivity

Abstract B08: ETC inhibitors alter oncogenic KRAS signal transduction

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