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Molecular mechanisms of amyloid-β peptide fibril and oligomer formation: NMR-based challenges

Biophysics and Physicobiology, 2023, Vol.20(1), pp.e200007

Hiroaki, Hidekazu

2023

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Common molecular pathogenesis of disease-related intrinsically disordered proteins revealed by NMR analysis

Journal of biochemistry (Tokyo), 2018-01, Vol.163 (1), p.11

2018

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Recent applications of isotopic labeling for protein NMR in drug discovery

Expert opinion on drug discovery, 2013-05, Vol.8 (5), p.523-536

Hiroaki, Hidekazu

2013

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Potential of rescue and reactivation of tumor suppressor p53 for cancer therapy

Biophysical reviews, 2022-02, Vol.14 (1), p.267-275

2022

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NMR-Guided Repositioning of Non-Steroidal Anti-Inflammatory Drugs into Tight Junction Modulators

International journal of molecular sciences, 2021-03, Vol.22 (5), p.2583

2021

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Presence of intrinsically disordered proteins can inhibit the nucleation phase of amyloid fibril formation of Aβ(1-42) in amino acid sequence independent manner

Scientific reports, 2020-07, Vol.10 (1), p.12334-12334, Article 12334

2020

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Insights into the Mechanisms of Oligomerization/Fibrilization of Amyloid β Peptide from Nuclear Magnetic Resonance

Seibutsu Butsuri, 2022, Vol.62(1), pp.39-42

HIROAKI, Hidekazu

2022

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Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly

Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (32), p.E4465-E4474

2015

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Synthesis of selenomethylene-locked nucleic acids (SeLNA) nucleoside unit bearing an adenine base

Nucleosides, nucleotides & nucleic acids, 2020-02, Vol.39 (1-3), p.131-140

2020

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Structural Basis for the Multiple Interactions of the MyD88 TIR Domain in TLR4 Signaling

Proceedings of the National Academy of Sciences - PNAS, 2009-06, Vol.106 (25), p.10260-10265

2009

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Opposing Effect of Naringenin and Quercetin on the Junctional Compartment of MDCK II Cells to Modulate the Tight Junction

Nutrients, 2020-10, Vol.12 (11), p.3285

2020

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Relevance of Amorphous and Amyloid-Like Aggregates of the p53 Core Domain to Loss of its DNA-Binding Activity

Frontiers in molecular biosciences, 2022-04, Vol.9, p.869851-869851

2022

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Small-Molecule-Mediated Suppression of BMP Signaling by Selective Inhibition of BMP1-Dependent Chordin Cleavage

International journal of molecular sciences, 2023-02, Vol.24 (5), p.4313

2023

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Using 1HN amide temperature coefficients to define intrinsically disordered regions: An alternative NMR method

Protein science, 2018-10, Vol.27 (10), p.1821-1830

2018

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SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain

The Journal of cell biology, 2011-05, Vol.193 (5), p.901-916

2011

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Cryoprotective activities of FK20, a human genome-derived intrinsically disordered peptide against cryosensitive enzymes without a stereospecific molecular interaction

PeerJ physical chemistry, 2021-12, Vol.3, p.e20, Article e20

2021

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Discovery of Cryoprotective Activity in Human Genome-Derived Intrinsically Disordered Proteins

International journal of molecular sciences, 2018-01, Vol.19 (2), p.401

2018

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Pharmacologic Comparison of High-Dose Hesperetin and Quercetin on MDCK II Cell Viability, Tight Junction Integrity, and Cell Shape

Antioxidants, 2023-04, Vol.12 (4), p.952

2023

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Spatial Overlap of Claudin- and Phosphatidylinositol Phosphate-Binding Sites on the First PDZ Domain of Zonula Occludens 1 Studied by NMR

Molecules (Basel, Switzerland), 2018-09, Vol.23 (10), p.2465

2018

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Discovery of Potent Disheveled/Dvl Inhibitors Using Virtual Screening Optimized With NMR-Based Docking Performance Index

Frontiers in pharmacology, 2018-09, Vol.9, p.983-983

2018

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Nuclear magnetic resonance evidence for the dimer formation of beta amyloid peptide 1–42 in 1,1,1,3,3,3-hexafluoro-2-propanol

Analytical biochemistry, 2016-04, Vol.498, p.59-67

2016

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Multiple Interactions of the Intrinsically Disordered Region between the Helicase and Nuclease Domains of the Archaeal Hef Protein

The Journal of biological chemistry, 2014-08, Vol.289 (31), p.21627-21639

2014

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Crystal structure of thymine DNA glycosylase conjugated to SUMO-1

Nature, 2005-06, Vol.435 (7044), p.979-982

2005

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A cryptic phosphate-binding pocket on the SPFH domain of human stomatin that regulates a novel fibril-like self-assembly

Current research in structural biology, 2022-01, Vol.4, p.158-166

2022

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Molecular mechanisms of amyloid-β peptide fibril and oligomer formation: NMR-based challenges

Biophysics and Physicobiology, 2023, pp.e200007

Hiroaki, Hidekazu

2023

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Molecular mechanisms of amyloid-β peptide fibril and oligomer formation: NMR-based challenges

Common molecular pathogenesis of disease-related intrinsically disordered proteins revealed by NMR analysis

Recent applications of isotopic labeling for protein NMR in drug discovery

Potential of rescue and reactivation of tumor suppressor p53 for cancer therapy

NMR-Guided Repositioning of Non-Steroidal Anti-Inflammatory Drugs into Tight Junction Modulators

Presence of intrinsically disordered proteins can inhibit the nucleation phase of amyloid fibril formation of Aβ(1-42) in amino acid sequence independent manner

Insights into the Mechanisms of Oligomerization/Fibrilization of Amyloid β Peptide from Nuclear Magnetic Resonance

Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly

Synthesis of selenomethylene-locked nucleic acids (SeLNA) nucleoside unit bearing an adenine base

Structural Basis for the Multiple Interactions of the MyD88 TIR Domain in TLR4 Signaling

Opposing Effect of Naringenin and Quercetin on the Junctional Compartment of MDCK II Cells to Modulate the Tight Junction

Relevance of Amorphous and Amyloid-Like Aggregates of the p53 Core Domain to Loss of its DNA-Binding Activity

Small-Molecule-Mediated Suppression of BMP Signaling by Selective Inhibition of BMP1-Dependent Chordin Cleavage

Using 1HN amide temperature coefficients to define intrinsically disordered regions: An alternative NMR method

SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain

Cryoprotective activities of FK20, a human genome-derived intrinsically disordered peptide against cryosensitive enzymes without a stereospecific molecular interaction

Discovery of Cryoprotective Activity in Human Genome-Derived Intrinsically Disordered Proteins

Pharmacologic Comparison of High-Dose Hesperetin and Quercetin on MDCK II Cell Viability, Tight Junction Integrity, and Cell Shape

Spatial Overlap of Claudin- and Phosphatidylinositol Phosphate-Binding Sites on the First PDZ Domain of Zonula Occludens 1 Studied by NMR

Discovery of Potent Disheveled/Dvl Inhibitors Using Virtual Screening Optimized With NMR-Based Docking Performance Index

Nuclear magnetic resonance evidence for the dimer formation of beta amyloid peptide 1–42 in 1,1,1,3,3,3-hexafluoro-2-propanol

Multiple Interactions of the Intrinsically Disordered Region between the Helicase and Nuclease Domains of the Archaeal Hef Protein

Crystal structure of thymine DNA glycosylase conjugated to SUMO-1

A cryptic phosphate-binding pocket on the SPFH domain of human stomatin that regulates a novel fibril-like self-assembly

Molecular mechanisms of amyloid-β peptide fibril and oligomer formation: NMR-based challenges

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