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Understanding Tubulin-Taxol Interactions: Mutations That Impart Taxol Binding to Yeast Tubulin

Proceedings of the National Academy of Sciences - PNAS, 2003-05, Vol.100 (11), p.6394-6397

2003

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Epothilone and Paclitaxel: Unexpected Differences in Promoting the Assembly and Stabilization of Yeast Microtubules

Biochemistry (Easton), 2002-03, Vol.41 (12), p.3870-3874

2002

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Paclitaxel‐induced microtubule stabilization causes mitotic block and apoptotic‐like cell death in a paclitaxel‐sensitive strain of Saccharomyces cerevisiae

Yeast (Chichester, England), 2005-09, Vol.22 (12), p.971-978

2005

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Suppression of Microtubule Dynamic Instability and Treadmilling by Deuterium Oxide

Biochemistry (Easton), 2000-05, Vol.39 (17), p.5075-5081

2000

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Differences in Paclitaxel and Docetaxel Interactions with Tubulin Detected by Mutagenesis of Yeast Tubulin

ChemMedChem, 2008-12, Vol.3 (12), p.1844-1847

2008

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Intrinsically Slow Dynamic Instability of HeLa Cell Microtubules in Vitro

The Journal of biological chemistry, 2002-11, Vol.277 (45), p.42456-42462

2002

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Stabilization of Tubulin by Deuterium Oxide

Biochemistry (Easton), 1999-03, Vol.38 (10), p.3067-3072

1999

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Chemical Modification of Paclitaxel (Taxol) Reduces P-Glycoprotein Interactions and Increases Permeation across the Blood−Brain Barrier in Vitro and in Situ

Journal of medicinal chemistry, 2005-02, Vol.48 (3), p.832-838

2005

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A label-free mass spectrometry method for the quantification of protein isotypes

Analytical biochemistry, 2009-12, Vol.395 (2), p.217-223

2009

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Design, synthesis, and antiproliferative and CDK2-cyclin a inhibitory activity of novel flavopiridol analogues

Bioorganic & medicinal chemistry, 2007-01, Vol.15 (2), p.702-713

2007

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Paclitaxel succinate analogs: Anionic and amide introduction as a strategy to impart blood–brain barrier permeability

Bioorganic & medicinal chemistry, 2008-11, Vol.18 (22), p.5971-5974

2008

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Differentiating between Models of Epothilone Binding to Microtubules Using Tubulin Mutagenesis, Cytotoxicity, and Molecular Modeling

ChemMedChem, 2012-09, Vol.7 (9), p.1580-1586

2012

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Total Synthesis and Evaluation of C26-Hydroxyepothilone D Derivatives for Photoaffinity Labeling of β-Tubulin

Journal of organic chemistry, 2010-01, Vol.75 (1), p.86-94

2010

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The paclitaxel site in tubulin probed by site-directed mutagenesis of Saccharomyces cerevisiae β-tubulin

FEBS letters, 2008-07, Vol.582 (16), p.2467-2470

2008

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(3R,5S,7as)-(3,5-Bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol, a Novel Neuroprotective Agent

Journal of medicinal chemistry, 2009-12, Vol.52 (23), p.7537-7543

2009

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Enantiospecific synthesis and cytotoxicity of 7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5(1 H)-one enantiomers

Bioorganic & medicinal chemistry, 2008-04, Vol.16 (8), p.4367-4377

2008

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The two α-tubulin isotypes in budding yeast have opposing effects on microtubule dynamics in vitro

EMBO reports, 2003-01, Vol.4 (1), p.94-99

2003

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Synthesis, in vitro and in vivo cytotoxicity of 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-ones

Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (16), p.4703-4707

2007

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Synthesis and evaluation of heteroaromatic 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1 H)-ones for cytotoxicity against the HCT-116 colon cancer cell line

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (11), p.3248-3250

2008

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Synthesis, tubulin assembly, and antiproliferative activity against MCF7 and NCI/ADR-RES cancer cells of 10-O-acetyl-5'-hydroxybutitaxel

Bioorganic & medicinal chemistry, 2008-12, Vol.18 (23), p.6165-6167

2008

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Synthesis of Cryptophycins via an N-Acyl-β-lactam Macrolactonization

Journal of organic chemistry, 2003-12, Vol.68 (25), p.9687-9693

2003

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Synthesis and Anti-Tubulin Activity of a 3‘-(4-Azidophenyl)-3‘-dephenylpaclitaxel Photoaffinity Probe

Journal of medicinal chemistry, 2004-12, Vol.47 (26), p.6459-6465

2004

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beta-Tubulin C354 mutations that severely decrease microtubule dynamics do not prevent nuclear migration in yeast

Molecular biology of the cell, 2002-08, Vol.13 (8), p.2919-2932

2002

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Mechanism of Action of the Unusually Potent Microtubule Inhibitor Cryptophycin 1

Biochemistry (Easton), 1997-10, Vol.36 (42), p.12948-12953

1997

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Synthesis, Modeling, and Anti-Tubulin Activity of a D-Seco Paclitaxel Analogue

Organic letters, 2004-02, Vol.6 (4), p.461-464

2004

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Understanding Tubulin-Taxol Interactions: Mutations That Impart Taxol Binding to Yeast Tubulin

Epothilone and Paclitaxel: Unexpected Differences in Promoting the Assembly and Stabilization of Yeast Microtubules

Paclitaxel‐induced microtubule stabilization causes mitotic block and apoptotic‐like cell death in a paclitaxel‐sensitive strain of Saccharomyces cerevisiae

Suppression of Microtubule Dynamic Instability and Treadmilling by Deuterium Oxide

Differences in Paclitaxel and Docetaxel Interactions with Tubulin Detected by Mutagenesis of Yeast Tubulin

Intrinsically Slow Dynamic Instability of HeLa Cell Microtubules in Vitro

Stabilization of Tubulin by Deuterium Oxide

Chemical Modification of Paclitaxel (Taxol) Reduces P-Glycoprotein Interactions and Increases Permeation across the Blood−Brain Barrier in Vitro and in Situ

A label-free mass spectrometry method for the quantification of protein isotypes

Design, synthesis, and antiproliferative and CDK2-cyclin a inhibitory activity of novel flavopiridol analogues

Paclitaxel succinate analogs: Anionic and amide introduction as a strategy to impart blood–brain barrier permeability

Differentiating between Models of Epothilone Binding to Microtubules Using Tubulin Mutagenesis, Cytotoxicity, and Molecular Modeling

Total Synthesis and Evaluation of C26-Hydroxyepothilone D Derivatives for Photoaffinity Labeling of β-Tubulin

The paclitaxel site in tubulin probed by site-directed mutagenesis of Saccharomyces cerevisiae β-tubulin

(3R,5S,7as)-(3,5-Bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol, a Novel Neuroprotective Agent

Enantiospecific synthesis and cytotoxicity of 7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5(1 H)-one enantiomers

The two α-tubulin isotypes in budding yeast have opposing effects on microtubule dynamics in vitro

Synthesis, in vitro and in vivo cytotoxicity of 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-ones

Synthesis and evaluation of heteroaromatic 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1 H)-ones for cytotoxicity against the HCT-116 colon cancer cell line

Synthesis, tubulin assembly, and antiproliferative activity against MCF7 and NCI/ADR-RES cancer cells of 10-O-acetyl-5'-hydroxybutitaxel

Synthesis of Cryptophycins via an N-Acyl-β-lactam Macrolactonization

Synthesis and Anti-Tubulin Activity of a 3‘-(4-Azidophenyl)-3‘-dephenylpaclitaxel Photoaffinity Probe

beta-Tubulin C354 mutations that severely decrease microtubule dynamics do not prevent nuclear migration in yeast

Mechanism of Action of the Unusually Potent Microtubule Inhibitor Cryptophycin 1

Synthesis, Modeling, and Anti-Tubulin Activity of a D-Seco Paclitaxel Analogue

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