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The human milk oligosaccharides 2'-fucosyllactose and 6'-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling

Pediatric research, 2021-01, Vol.89 (1), p.91-101

2021

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Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis

The Journal of clinical investigation, 2016-02, Vol.126 (2), p.495-508

2016

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Novel role for the innate immune receptor Toll-like receptor 4 (TLR4) in the regulation of the Wnt signaling pathway and photoreceptor apoptosis

PloS one, 2012-05, Vol.7 (5), p.e36560-e36560

2012

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A Dynamic Variation of Pulmonary ACE2 Is Required to Modulate Neutrophilic Inflammation in Response to Pseudomonas aeruginosa Lung Infection in Mice

The Journal of immunology (1950), 2019-12, Vol.203 (11), p.3000-3012

2019

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Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors

PloS one, 2013-06, Vol.8 (6), p.e65779-e65779

2013

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The human milk oligosaccharide 2′-fucosyllactose attenuates the severity of experimental necrotising enterocolitis by enhancing mesenteric perfusion in the neonatal intestine

British journal of nutrition, 2016-10, Vol.116 (7), p.1175-1187

2016

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Necrotizing enterocolitis, gut microbes, and sepsis

Gut microbes, 2023-12, Vol.15 (1), p.2221470

2023

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Precision-based modeling approaches for necrotizing enterocolitis

Disease models & mechanisms, 2020-06, Vol.13 (6)

2020

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Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis

Nature communications, 2021-02, Vol.12 (1), p.1042-14, Article 1042

2021

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Dysregulated Mucosal Immunity and Associated Pathogeneses in Preterm Neonates

Frontiers in immunology, 2020-05, Vol.11, p.899-899

2020

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Mucosa-associated bacterial diversity in necrotizing enterocolitis

PloS one, 2014-09, Vol.9 (9), p.e105046-e105046

2014

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The role of epithelial Toll-like receptor signaling in the pathogenesis of intestinal inflammation

Journal of leukocyte biology, 2008-03, Vol.83 (3), p.493-498

2008

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Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch

Seminars in pediatric surgery, 2013-05, Vol.22 (2), p.76-82

2013

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Prenatal Immunity and Influences on Necrotizing Enterocolitis and Associated Neonatal Disorders

Frontiers in immunology, 2021-04, Vol.12, p.650709-650709

2021

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Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS–NO–nitrite signaling

Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (23), p.9451-9456

2013

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A Critical Role for TLR4 in the Pathogenesis of Necrotizing Enterocolitis by Modulating Intestinal Injury and Repair

Journal of Immunology, 2007-10, Vol.179 (7), p.4808-4820

2007

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Toll-like Receptor 4-mediated Endoplasmic Reticulum Stress in Intestinal Crypts Induces Necrotizing Enterocolitis

The Journal of biological chemistry, 2014-04, Vol.289 (14), p.9584-9599

2014

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Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut

The Journal of immunology (1950), 2015-05, Vol.194 (10), p.4931-4939

2015

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Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents

The Journal of neuroscience, 2017-02, Vol.37 (5), p.1139-1155

2017

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Animal models of gastrointestinal and liver diseases. Animal models of necrotizing enterocolitis: pathophysiology, translational relevance, and challenges

American journal of physiology: Gastrointestinal and liver physiology, 2014-06, Vol.306 (11), p.G917-G928

2014

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The dawn of the third renaissance in surgery

Surgery, 2015-08, Vol.158 (2), p.317-322

Hackam, David J., MD, PhD

2015

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Cellular‐specific role of toll‐like receptor 4 in hepatic ischemia‐reperfusion injury in mice

Hepatology (Baltimore, Md.), 2013-07, Vol.58 (1), p.374-387

2013

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A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis

The Journal of immunology (1950), 2013-04, Vol.190 (7), p.3541-3551

2013

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HMGB1-Driven Inflammation and Intimal Hyperplasia After Arterial Injury Involves Cell-Specific Actions Mediated by TLR4

Arteriosclerosis, thrombosis, and vascular biology, 2015-12, Vol.35 (12), p.2579-2593

2015

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Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium

Proceedings of the National Academy of Sciences - PNAS, 2012-07, Vol.109 (28), p.11330-11335

2012

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The human milk oligosaccharides 2'-fucosyllactose and 6'-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling

Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis

Novel role for the innate immune receptor Toll-like receptor 4 (TLR4) in the regulation of the Wnt signaling pathway and photoreceptor apoptosis

A Dynamic Variation of Pulmonary ACE2 Is Required to Modulate Neutrophilic Inflammation in Response to Pseudomonas aeruginosa Lung Infection in Mice

Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors

The human milk oligosaccharide 2′-fucosyllactose attenuates the severity of experimental necrotising enterocolitis by enhancing mesenteric perfusion in the neonatal intestine

Necrotizing enterocolitis, gut microbes, and sepsis

Precision-based modeling approaches for necrotizing enterocolitis

Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis

Dysregulated Mucosal Immunity and Associated Pathogeneses in Preterm Neonates

Mucosa-associated bacterial diversity in necrotizing enterocolitis

The role of epithelial Toll-like receptor signaling in the pathogenesis of intestinal inflammation

Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch

Prenatal Immunity and Influences on Necrotizing Enterocolitis and Associated Neonatal Disorders

Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS–NO–nitrite signaling

A Critical Role for TLR4 in the Pathogenesis of Necrotizing Enterocolitis by Modulating Intestinal Injury and Repair

Toll-like Receptor 4-mediated Endoplasmic Reticulum Stress in Intestinal Crypts Induces Necrotizing Enterocolitis

Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut

Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents

Animal models of gastrointestinal and liver diseases. Animal models of necrotizing enterocolitis: pathophysiology, translational relevance, and challenges

The dawn of the third renaissance in surgery

Cellular‐specific role of toll‐like receptor 4 in hepatic ischemia‐reperfusion injury in mice

A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis

HMGB1-Driven Inflammation and Intimal Hyperplasia After Arterial Injury Involves Cell-Specific Actions Mediated by TLR4

Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium

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