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Tumor Killing by CD4 + T Cells Is Mediated via Induction of Inducible Nitric Oxide Synthase-Dependent Macrophage Cytotoxicity

Frontiers in immunology, 2018-07, Vol.9, p.1684-1684

2018

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How Do CD4(+) T Cells Detect and Eliminate Tumor Cells That Either Lack or Express MHC Class II Molecules?

Frontiers in immunology, 2014, Vol.5, p.174-174

2014

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CD4+ T-cell killing of multiple myeloma cells is mediated by resident bone marrow macrophages

Blood advances, 2020-06, Vol.4 (12), p.2595-2605

2020

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CD4 + T-cell-Mediated Rejection of MHC Class II-Positive Tumor Cells Is Dependent on Antigen Secretion and Indirect Presentation on Host APCs

Cancer research (Chicago, Ill.), 2018-08, Vol.78 (16), p.4573-4585

2018

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Local Delivery of Ox40l , Cd80 , and Cd86 mRNA Kindles Global Anticancer Immunity

Cancer research (Chicago, Ill.), 2019-04, Vol.79 (7), p.1624-1634

2019

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B cell receptor ligation induces display of V-region peptides on MHC class II molecules to T cells

Proceedings of the National Academy of Sciences - PNAS, 2019-12, Vol.116 (51), p.25850-25859

2019

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Interleukin-1 is required for cancer eradication mediated by tumor-specific Th1 cells

Oncoimmunology, 2016-01, Vol.5 (1), p.e1039763-e1039763

2016

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Naive idiotope-specific B and T cells collaborate efficiently in the absence of dendritic cells

The Journal of immunology (1950), 2014-05, Vol.192 (9), p.4174-4183

2014

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Indirect CD4+ T-cell-mediated elimination of MHC II(NEG) tumor cells is spatially restricted and fails to prevent escape of antigen-negative cells

European journal of immunology, 2014-09, Vol.44 (9), p.2625-2637

2014

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Indirect CD4+ T‐cell‐mediated elimination of MHC IINEG tumor cells is spatially restricted and fails to prevent escape of antigen‐negative cells

European journal of immunology, 2014-09, Vol.44 (9), p.2625-2637

2014

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A model for cancer-suppressive inflammation

Oncoimmunology, 2012-10, Vol.1 (7), p.1146-1155

2012

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1359 NTX-0471, engineered multivalent SIRPa and bispecific SIRPa-antiCCR4 molecules demonstrate superior activity providing path for mRNA expressed in-vivo biologics

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A1514-A1515

2023

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CD4+ T cells indirectly kill tumor cells via induction of cytotoxic macrophages in mouse models

Cancer Immunology, Immunotherapy, 2019-11, Vol.68 (11), p.1865-1873

2019

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CS14-2. A cancer-protective role of inflammation

Cytokine (Philadelphia, Pa.), 2011-10, Vol.56 (1), p.101-101

2011

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Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer

Nature communications, 2011-03, Vol.2 (1), p.240-240, Article 240

2011

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Adoptive Transfer of Tumor-Specific Th2 Cells Eradicates Tumors by Triggering an In Situ Inflammatory Immune Response

Cancer research (Chicago, Ill.), 2016-12, Vol.76 (23), p.6864-6876

2016

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Tumor-specific CD4+ T cells eradicate myeloma cells genetically deficient in MHC class II display

Oncotarget, 2016-10, Vol.7 (41), p.67175-67182

2016

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Tumors Escape CD4+ T-cell-Mediated Immunosurveillance by Impairing the Ability of Infiltrating Macrophages to Indirectly Present Tumor Antigens

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (16), p.3268-3278

2015

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CSF1R-Inhibition and Reduction of Macrophages Delays Multiple Myeloma Growth in a Non-T-Cell-Dependent Manner

Blood, 2014-12, Vol.124 (21), p.5717-5717

2014

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Local delivery of OX40L, CD80, and CD86 mRNA kindles global anti-cancer immunity

Cancer research (Chicago, Ill.), 2019-01, Vol.79 (7), p.1624-1634

2019

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B cell receptor ligation induces display of V-region peptides on MHC class II molecules to T cells

Proceedings of the National Academy of Sciences - PNAS, 2019

2019

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Escape of myeloma cells from CD4 T-cell-driven immunoprotection (P2015)

The Journal of immunology (1950), 2013-05, Vol.190 (1_Supplement), p.53-53.8

2013

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Abstract 690: Modification of mRNA-encoded HPV16 antigens to include endolysosomal trafficking domains drives cross-presentation and results in superior in vivo and ex vivo antigen-specific responses

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.690-690

2023

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Abstract 5163: Local delivery of mRNA immunotherapy encoding HPV16 antigen, IL-12, and LIGHT/TNFSF14 results in superior immunogenicity and tumor clearance in a murine model of HPV16-driven cancer

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.5163-5163

2023

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Indirect CD4 + T‐cell‐mediated elimination of MHC II NEG tumor cells is spatially restricted and fails to prevent escape of antigen‐negative cells

European journal of immunology, 2014-09, Vol.44 (9), p.2625-2637

2014

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Tumor Killing by CD4 + T Cells Is Mediated via Induction of Inducible Nitric Oxide Synthase-Dependent Macrophage Cytotoxicity

How Do CD4(+) T Cells Detect and Eliminate Tumor Cells That Either Lack or Express MHC Class II Molecules?

CD4+ T-cell killing of multiple myeloma cells is mediated by resident bone marrow macrophages

CD4 + T-cell-Mediated Rejection of MHC Class II-Positive Tumor Cells Is Dependent on Antigen Secretion and Indirect Presentation on Host APCs

Local Delivery of Ox40l , Cd80 , and Cd86 mRNA Kindles Global Anticancer Immunity

B cell receptor ligation induces display of V-region peptides on MHC class II molecules to T cells

Interleukin-1 is required for cancer eradication mediated by tumor-specific Th1 cells

Naive idiotope-specific B and T cells collaborate efficiently in the absence of dendritic cells

Indirect CD4+ T-cell-mediated elimination of MHC II(NEG) tumor cells is spatially restricted and fails to prevent escape of antigen-negative cells

Indirect CD4+ T‐cell‐mediated elimination of MHC IINEG tumor cells is spatially restricted and fails to prevent escape of antigen‐negative cells

A model for cancer-suppressive inflammation

1359 NTX-0471, engineered multivalent SIRPa and bispecific SIRPa-antiCCR4 molecules demonstrate superior activity providing path for mRNA expressed in-vivo biologics

CD4+ T cells indirectly kill tumor cells via induction of cytotoxic macrophages in mouse models

CS14-2. A cancer-protective role of inflammation

Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer

Adoptive Transfer of Tumor-Specific Th2 Cells Eradicates Tumors by Triggering an In Situ Inflammatory Immune Response

Tumor-specific CD4+ T cells eradicate myeloma cells genetically deficient in MHC class II display

Tumors Escape CD4+ T-cell-Mediated Immunosurveillance by Impairing the Ability of Infiltrating Macrophages to Indirectly Present Tumor Antigens

CSF1R-Inhibition and Reduction of Macrophages Delays Multiple Myeloma Growth in a Non-T-Cell-Dependent Manner

Local delivery of OX40L, CD80, and CD86 mRNA kindles global anti-cancer immunity

B cell receptor ligation induces display of V-region peptides on MHC class II molecules to T cells

Escape of myeloma cells from CD4 T-cell-driven immunoprotection (P2015)

Abstract 690: Modification of mRNA-encoded HPV16 antigens to include endolysosomal trafficking domains drives cross-presentation and results in superior in vivo and ex vivo antigen-specific responses

Abstract 5163: Local delivery of mRNA immunotherapy encoding HPV16 antigen, IL-12, and LIGHT/TNFSF14 results in superior immunogenicity and tumor clearance in a murine model of HPV16-driven cancer

Indirect CD4 + T‐cell‐mediated elimination of MHC II NEG tumor cells is spatially restricted and fails to prevent escape of antigen‐negative cells

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