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RANK as a therapeutic target in cancer

The FEBS journal, 2016-06, Vol.283 (11), p.2018-2033

2016

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RANK Induces Epithelial―Mesenchymal Transition and Stemness in Human Mammary Epithelial Cells and Promotes Tumorigenesis and Metastasis

Cancer research (Chicago, Ill.), 2012-06, Vol.72 (11), p.2879-2888

2012

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Dual fatty acid synthase and HER2 signaling blockade shows marked antitumor activity against breast cancer models resistant to anti-HER2 drugs

PloS one, 2015-06, Vol.10 (6), p.e0131241

2015

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Resistance to Taxanes in Triple-Negative Breast Cancer Associates with the Dynamics of a CD49f+ Tumor-Initiating Population

Stem cell reports, 2017-05, Vol.8 (5), p.1392-1407

2017

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Rankl Impairs Lactogenic Differentiation Through Inhibition of the Prolactin/Stat5 Pathway at Midgestation

Stem cells (Dayton, Ohio), 2016-04, Vol.34 (4), p.1027-1039

2016

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Identification of NOG as a Specific Breast Cancer Bone Metastasis-supporting Gene

The Journal of biological chemistry, 2012-06, Vol.287 (25), p.21346-21355

2012

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RANKL inhibition: a promising novel strategy for breast cancer treatment

Clinical & translational oncology, 2011-04, Vol.13 (4), p.222-228

González-Suárez, Eva

2011

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Tumor-initiating CD49f cells are a hallmark of chemoresistant triple negative breast cancer

Molecular & cellular oncology, 2017-07, Vol.4 (4), p.e1338208-e1338208

2017

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Correction to: Rank ectopic expression in the presence of Neu and PyMT oncogenes alters mammary epithelial cell populations and their tumorigenic potential

Journal of mammary gland biology and neoplasia, 2023-12, Vol.28 (1), p.4-4, Article 4

2023

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Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes

The EMBO journal, 2001-06, Vol.20 (11), p.2619-2630

2001

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FN14 and GRP94 expression are prognostic/predictive biomarkers of brain metastasis outcome that open up new therapeutic strategies

Oncotarget, 2015-12, Vol.6 (42), p.44254-44273

2015

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Rank ectopic expression in the presence of Neu and MMTV oncogenes alters mammary epithelial cell populations and their tumorigenic potential

Journal of mammary gland biology and neoplasia, 2023-12, Vol.28 (1), p.2-2

2023

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Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells

Cancer cell, 2018-06, Vol.33 (6), p.1094-1110.e8

2018

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Luminal Rank loss decreases cell fitness leading to basal cell bipotency in parous mammary glands

Nature communications, 2023-10, Vol.14 (1), p.6213-6213, Article 6213

2023

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Cooperation between p53 Mutation and High Telomerase Transgenic Expression in Spontaneous Cancer Development

Molecular and Cellular Biology, 2002-10, Vol.22 (20), p.7291-7301

2002

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RANK Signaling Blockade Reduces Breast Cancer Recurrence by Inducing Tumor Cell Differentiation

Cancer research (Chicago, Ill.), 2016-10, Vol.76 (19), p.5857-5869

2016

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FGFR Inhibition Overcomes Resistance to EGFR-targeted Therapy in Epithelial-like Cutaneous Carcinoma

Clinical cancer research, 2021-03, Vol.27 (5), p.1491-1504

2021

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PDGFR-induced autocrine SDF-1 signaling in cancer cells promotes metastasis in advanced skin carcinoma

Oncogene, 2019-06, Vol.38 (25), p.5021-5037

2019

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The Altered Transcriptome and DNA Methylation Profiles of Docetaxel Resistance in Breast Cancer PDX Models

Molecular cancer research, 2019-10, Vol.17 (10), p.2063-2076

2019

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Normal Telomere Length and Chromosomal End Capping in Poly(ADP-Ribose) Polymerase-Deficient Mice and Primary Cells despite Increased Chromosomal Instability

The Journal of cell biology, 2001-07, Vol.154 (1), p.49-60

2001

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APRIL promotes breast tumor growth and metastasis and is associated with aggressive basal breast cancer

Carcinogenesis (New York), 2015-05, Vol.36 (5), p.574-584

2015

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Cancer Stem-like Cells Act via Distinct Signaling Pathways in Promoting Late Stages of Malignant Progression

Cancer research (Chicago, Ill.), 2016-03, Vol.76 (5), p.1245-1259

2016

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Exploiting Tumor Vulnerabilities: Epigenetics, Cancer Metabolism and the mTOR Pathway in the Era of Personalized Medicine

Cancer research, 2013-07, Vol.73 (14), p.4185-4189

2013

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RANK as a therapeutic target in cancer

RANK Induces Epithelial―Mesenchymal Transition and Stemness in Human Mammary Epithelial Cells and Promotes Tumorigenesis and Metastasis

Dual fatty acid synthase and HER2 signaling blockade shows marked antitumor activity against breast cancer models resistant to anti-HER2 drugs

Resistance to Taxanes in Triple-Negative Breast Cancer Associates with the Dynamics of a CD49f+ Tumor-Initiating Population

Rankl Impairs Lactogenic Differentiation Through Inhibition of the Prolactin/Stat5 Pathway at Midgestation

Identification of NOG as a Specific Breast Cancer Bone Metastasis-supporting Gene

RANKL inhibition: a promising novel strategy for breast cancer treatment

Tumor-initiating CD49f cells are a hallmark of chemoresistant triple negative breast cancer

Correction to: Rank ectopic expression in the presence of Neu and PyMT oncogenes alters mammary epithelial cell populations and their tumorigenic potential

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes

FN14 and GRP94 expression are prognostic/predictive biomarkers of brain metastasis outcome that open up new therapeutic strategies

Rank ectopic expression in the presence of Neu and MMTV oncogenes alters mammary epithelial cell populations and their tumorigenic potential

Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells

Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells

Luminal Rank loss decreases cell fitness leading to basal cell bipotency in parous mammary glands

Cooperation between p53 Mutation and High Telomerase Transgenic Expression in Spontaneous Cancer Development

RANK Signaling Blockade Reduces Breast Cancer Recurrence by Inducing Tumor Cell Differentiation

FGFR Inhibition Overcomes Resistance to EGFR-targeted Therapy in Epithelial-like Cutaneous Carcinoma

PDGFR-induced autocrine SDF-1 signaling in cancer cells promotes metastasis in advanced skin carcinoma

The Altered Transcriptome and DNA Methylation Profiles of Docetaxel Resistance in Breast Cancer PDX Models

Chromosome 12p Amplification in Triple-Negative/ BRCA1- Mutated Breast Cancer Associates with Emergence of Docetaxel Resistance and Carboplatin Sensitivity

Normal Telomere Length and Chromosomal End Capping in Poly(ADP-Ribose) Polymerase-Deficient Mice and Primary Cells despite Increased Chromosomal Instability

APRIL promotes breast tumor growth and metastasis and is associated with aggressive basal breast cancer

Cancer Stem-like Cells Act via Distinct Signaling Pathways in Promoting Late Stages of Malignant Progression

Exploiting Tumor Vulnerabilities: Epigenetics, Cancer Metabolism and the mTOR Pathway in the Era of Personalized Medicine

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