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A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

Nature medicine, 2015-01, Vol.21 (1), p.27-36

2015

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Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation

Journal of organic chemistry, 2017-04, Vol.82 (7), p.3506-3512

2017

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Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism

Molecular metabolism (Germany), 2019-02, Vol.20, p.51-62

2019

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Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host–microbe interactions

Proceedings of the National Academy of Sciences - PNAS, 2018-03, Vol.115 (10), p.2461-2466

2018

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Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists

Journal of medicinal chemistry, 2021-04, Vol.64 (8), p.4697-4708

2021

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Synthetic Advances in Insulin-like Peptides Enable Novel Bioactivity

Accounts of chemical research, 2017-08, Vol.50 (8), p.1855-1865

2017

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High-Yield Synthesis of Human Insulin-Like Peptide 5 Employing a Nonconventional Strategy

Organic letters, 2018-06, Vol.20 (12), p.3695-3699

2018

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Insulin-like peptide 5 fails to improve metabolism or body weight in obese mice

Peptides (New York, N.Y. : 1980), 2019-10, Vol.120, p.170116-170116, Article 170116

2019

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Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions

Diabetes (New York, N.Y.), 2013-05, Vol.62 (5), p.1453-1463

2013

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A new glucagon and GLP-1 co-agonist eliminates obesity in rodents

Nature chemical biology, 2009-10, Vol.5 (10), p.749-757

2009

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Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist

Nature communications, 2022-11, Vol.13 (1), p.6700-14, Article 6700

2022

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Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems

Molecular metabolism (Germany), 2022-12, Vol.66, p.101638-101638, Article 101638

2022

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Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence

Journal of medicinal chemistry, 2020-06, Vol.63 (11), p.6134-6143

2020

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Chemical Synthesis of Insulin Analogs through a Novel Precursor

ACS chemical biology, 2014-03, Vol.9 (3), p.683-691

2014

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Biomimetic Synthesis of Insulin Enabled by Oxime Ligation and Traceless “C-Peptide” Chemical Excision

Organic letters, 2017-02, Vol.19 (3), p.706-709

2017

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Synthesis and Characterization of the R27S Genetic Variant of Insulin‐like Peptide 5

ChemMedChem, 2018-04, Vol.13 (8), p.852-859

2018

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A Disulfide Scan of Insulin by [3 + 1] Methodology Exhibits Site-Specific Influence on Bioactivity

ACS chemical biology, 2019-08, Vol.14 (8), p.1829-1835

2019

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Controlled intramolecular antagonism as a regulator of insulin receptor maximal activity

Peptides (New York, N.Y. : 1980), 2018-02, Vol.100, p.18-23

2018

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A viral insulin-like peptide is a natural competitive antagonist of the human IGF-1 receptor

Molecular metabolism (Germany), 2021-11, Vol.53, p.101316-101316, Article 101316

2021

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Synthesis of relaxin‐2 and insulin‐like peptide 5 enabled by novel tethering and traceless chemical excision

Journal of peptide science, 2017-06, Vol.23 (6), p.455-465

2017

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A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression

Molecular metabolism (Germany), 2024-02, Vol.80, p.101863-101863, Article 101863

2024

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Synthesis of disulfide-rich heterodimeric peptides through an auxiliary N, N-crosslink

Communications chemistry, 2018-06, Vol.1 (1), Article 36

2018

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Max Bergmann award lecture:Macromolecular medicinal chemistry as applied to metabolic diseases

Journal of peptide science, 2018-01, Vol.24 (1), p.n/a

2018

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A Novel Human-Based Receptor Antagonist of Sustained Action Reveals Body Weight Control by Endogenous GLP-1

ACS chemical biology, 2011-02, Vol.6 (2), p.135-145

2011

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A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation

Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans

Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism

Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host–microbe interactions

Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists

Synthetic Advances in Insulin-like Peptides Enable Novel Bioactivity

High-Yield Synthesis of Human Insulin-Like Peptide 5 Employing a Nonconventional Strategy

Insulin-like peptide 5 fails to improve metabolism or body weight in obese mice

Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents

Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist

Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems

Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence

Chemical Synthesis of Insulin Analogs through a Novel Precursor

Biomimetic Synthesis of Insulin Enabled by Oxime Ligation and Traceless “C-Peptide” Chemical Excision

Synthesis and Characterization of the R27S Genetic Variant of Insulin‐like Peptide 5

A Disulfide Scan of Insulin by [3 + 1] Methodology Exhibits Site-Specific Influence on Bioactivity

Controlled intramolecular antagonism as a regulator of insulin receptor maximal activity

A viral insulin-like peptide is a natural competitive antagonist of the human IGF-1 receptor

Synthesis of relaxin‐2 and insulin‐like peptide 5 enabled by novel tethering and traceless chemical excision

A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression

Synthesis of disulfide-rich heterodimeric peptides through an auxiliary N, N-crosslink

Max Bergmann award lecture:Macromolecular medicinal chemistry as applied to metabolic diseases

A Novel Human-Based Receptor Antagonist of Sustained Action Reveals Body Weight Control by Endogenous GLP-1

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