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Estetrol: From Preclinical to Clinical Pharmacology and Advances in the Understanding of the Molecular Mechanism of Action

Drugs in R&D, 2023-06, Vol.23 (2), p.77-92

2023

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Role of membrane estrogen receptor alpha (ERα) in the rapid regulation of male sexual behavior

Journal of neuroendocrinology, 2023-10, Vol.35 (10), p.e13341-e13341

2023

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Human Chorionic Gonadotrophin: New Pleiotropic Functions for an "Old" Hormone During Pregnancy

Frontiers in immunology, 2020-03, Vol.11, p.343-343

2020

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Hyperglycosylated human chorionic gonadotropin stimulates angiogenesis through TGF‐β receptor activation

The FASEB journal, 2013-04, Vol.27 (4), p.1309-1321

2013

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Specific and extensive endometrial deregulation is present before conception in IVF/ICSI repeated implantation failures (IF) or recurrent miscarriages

The Journal of pathology, 2011-12, Vol.225 (4), p.554-564

2011

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Estetrol and Mammary Gland: Friends or Foes?

Journal of mammary gland biology and neoplasia, 2021-09, Vol.26 (3), p.297-308

2021

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Pooled efficacy results of estetrol/drospirenone combined oral contraception phase 3 trials

Contraception (Stoneham), 2022-12, Vol.116, p.37-43

2022

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A membrane-type-1 matrix metalloproteinase (MT1-MMP)-discoidin domain receptor 1 axis regulates collagen-induced apoptosis in breast cancer cells

PloS one, 2015-03, Vol.10 (3), p.e0116006-e0116006

2015

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Predominant Role of Nuclear Versus Membrane Estrogen Receptor α in Arterial Protection: Implications for Estrogen Receptor α Modulation in Cardiovascular Prevention/Safety

Journal of the American Heart Association, 2018-06, Vol.7 (13)

2018

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Soluble factors regulated by epithelial-mesenchymal transition mediate tumour angiogenesis and myeloid cell recruitment

The Journal of pathology, 2015-08, Vol.236 (4), p.491-504

2015

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Safety and efficacy of tibolone in breast-cancer patients with vasomotor symptoms: a double-blind, randomised, non-inferiority trial

The lancet oncology, 2009-02, Vol.10 (2), p.135-146

2009

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Comparison of Estetrol Exposure between Women and Mice to Model Preclinical Experiments and Anticipate Human Treatment

International journal of molecular sciences, 2023-06, Vol.24 (11), p.9718

2023

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Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in the respiratory tract: Potential implications in asthma and other lung diseases

European journal of pharmacology, 2006-03, Vol.533 (1-3), p.133-144

2006

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Hypoxia is responsible for soluble vascular endothelial growth factor receptor-1 (VEGFR-1) but not for soluble endoglin induction in villous trophoblast

Human reproduction (Oxford), 2008-06, Vol.23 (6), p.1407-1415

2008

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Altered α-defensin 5 expression in cervical squamocolumnar junction: implication in the formation of a viral/tumour-permissive microenvironment

The Journal of pathology, 2014-12, Vol.234 (4), p.464-477

2014

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Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid

The Journal of pharmacology and experimental therapeutics, 2002-09, Vol.302 (3), p.1055

2002

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The Activation Function-1 of Estrogen Receptor Alpha Prevents Arterial Neointima Development Through a Direct Effect on Smooth Muscle Cells

Circulation research, 2015-10, Vol.117 (9), p.770-778

2015

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A paracrine interaction between granulosa cells and leukocytes in the preovulatory follicle causes the increase in follicular G-CSF levels

Journal of assisted reproduction and genetics, 2020-02, Vol.37 (2), p.405-416

2020

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Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase

Blood, 2012-05, Vol.119 (21), p.5048-5056

2012

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Estetrol Combined to Progestogen for Menopause or Contraception Indication Is Neutral on Breast Cancer

Cancers, 2021-05, Vol.13 (10), p.2486

2021

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Isoform 111 of vascular endothelial growth factor (VEGF111) improves angiogenesis of ovarian tissue xenotransplantation

Transplantation, 2013-02, Vol.95 (3), p.426

2013

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The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts

Cell reports (Cambridge), 2015-08, Vol.12 (6), p.992-1005

2015

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Reduction of apoptosis and proliferation in endometriosis

Fertility and sterility, 2004-07, Vol.82 (1), p.80-85

2004

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Overexpression of the Soluble Vascular Endothelial Growth Factor Receptor in Preeclamptic Patients: Pathophysiological Consequences

The journal of clinical endocrinology and metabolism, 2003-11, Vol.88 (11), p.5555-5563

2003

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Response to paper by Binkowska et al. Risk of venous thromboembolism during the use of oral estrogen-progestogen hormone therapies in light of most recent research findings. Commentary: Oestradiol is not the holy grail in the quest for the ideal oestrogen therapy

Przegla̜d menopauzalny, 2023-06, Vol.22 (2), p.117-119

2023

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Estetrol: From Preclinical to Clinical Pharmacology and Advances in the Understanding of the Molecular Mechanism of Action

Role of membrane estrogen receptor alpha (ERα) in the rapid regulation of male sexual behavior

Human Chorionic Gonadotrophin: New Pleiotropic Functions for an "Old" Hormone During Pregnancy

Hyperglycosylated human chorionic gonadotropin stimulates angiogenesis through TGF‐β receptor activation

Specific and extensive endometrial deregulation is present before conception in IVF/ICSI repeated implantation failures (IF) or recurrent miscarriages

Estetrol and Mammary Gland: Friends or Foes?

Pooled efficacy results of estetrol/drospirenone combined oral contraception phase 3 trials

A membrane-type-1 matrix metalloproteinase (MT1-MMP)-discoidin domain receptor 1 axis regulates collagen-induced apoptosis in breast cancer cells

Predominant Role of Nuclear Versus Membrane Estrogen Receptor α in Arterial Protection: Implications for Estrogen Receptor α Modulation in Cardiovascular Prevention/Safety

Soluble factors regulated by epithelial-mesenchymal transition mediate tumour angiogenesis and myeloid cell recruitment

Safety and efficacy of tibolone in breast-cancer patients with vasomotor symptoms: a double-blind, randomised, non-inferiority trial

Comparison of Estetrol Exposure between Women and Mice to Model Preclinical Experiments and Anticipate Human Treatment

Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in the respiratory tract: Potential implications in asthma and other lung diseases

Hypoxia is responsible for soluble vascular endothelial growth factor receptor-1 (VEGFR-1) but not for soluble endoglin induction in villous trophoblast

Altered α-defensin 5 expression in cervical squamocolumnar junction: implication in the formation of a viral/tumour-permissive microenvironment

Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid

The Activation Function-1 of Estrogen Receptor Alpha Prevents Arterial Neointima Development Through a Direct Effect on Smooth Muscle Cells

A paracrine interaction between granulosa cells and leukocytes in the preovulatory follicle causes the increase in follicular G-CSF levels

Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase

Estetrol Combined to Progestogen for Menopause or Contraception Indication Is Neutral on Breast Cancer

Isoform 111 of vascular endothelial growth factor (VEGF111) improves angiogenesis of ovarian tissue xenotransplantation

The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts

Reduction of apoptosis and proliferation in endometriosis

Overexpression of the Soluble Vascular Endothelial Growth Factor Receptor in Preeclamptic Patients: Pathophysiological Consequences

Response to paper by Binkowska et al. Risk of venous thromboembolism during the use of oral estrogen-progestogen hormone therapies in light of most recent research findings. Commentary: Oestradiol is not the holy grail in the quest for the ideal oestrogen therapy

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