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Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor

Nature (London), 2016-03, Vol.531 (7594), p.386-389

2016

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The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection

PloS one, 2017-01, Vol.12 (1), p.e0169648-e0169648

2017

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“I didn’t know women could have haemophilia”: A qualitative case study

Journal of Haemophilia Practice, 2022-07, Vol.9 (1), p.85-95

Fletcher, Simon

2022

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Seeing the bigger picture: Qualitative research in the Zoom ® age

Journal of Haemophilia Practice, 2021-12, Vol.8 (1), p.141-144

Fletcher, Simon

2021

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Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism

Journal of hepatology, 2018-05, Vol.68 (5), p.922-931

2018

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Ongoing viral replication and production of infectious virus in patients with chronic hepatitis B virus suppressed below the limit of quantitation on long-term nucleos(t)ide therapy

PloS one, 2022-04, Vol.17 (4), p.e0262516-e0262516

2022

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Targeting lipid biosynthesis pathways for hepatitis B virus cure

PloS one, 2022-08, Vol.17 (8), p.e0270273-e0270273

2022

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PD-1 blockade partially recovers dysfunctional virus-specific B cells in chronic hepatitis B infection

The Journal of clinical investigation, 2018-10, Vol.128 (10), p.4573-4587

2018

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Identifying and Characterizing Interplay between Hepatitis B Virus X Protein and Smc5/6

Viruses, 2017-04, Vol.9 (4), p.69

2017

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Barriers to gene therapy, understanding the concerns people with haemophilia have: an exigency sub-study

Orphanet journal of rare diseases, 2024-02, Vol.19 (1), p.59-59

2024

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Therapeutic shutdown of HBV transcripts promotes reappearance of the SMC5/6 complex and silencing of the viral genome in vivo

Gut, 2022-02, Vol.71 (2), p.372

2022

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Toll‐like receptor 7 agonist, GS‐986, is an immune‐stimulant inducing follicular helper T cells and expanding HBs antigen‐specific B cells in vitro

Liver international, 2023-06, Vol.43 (6), p.1213-1224

2023

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Smc5/6 silences episomal transcription by a three-step function

Nature structural & molecular biology, 2022-09, Vol.29 (9), p.922

2022

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Spatiotemporal Analysis of Hepatitis B Virus X Protein in Primary Human Hepatocytes

Journal of virology, 2019-08, Vol.93 (16)

2019

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The problem with self-management: Problematising self-management and power using a Foucauldian lens in the context of stroke care and rehabilitation

PloS one, 2019-06, Vol.14 (6), p.e0218517-e0218517

2019

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Toll‐Like Receptor 8 Agonist GS‐9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B

Hepatology (Baltimore, Md.), 2021-01, Vol.73 (1), p.53-67

2021

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Therapeutic Potential of TLR8 Agonist GS‐9688 (Selgantolimod) in Chronic Hepatitis B: Remodeling of Antiviral and Regulatory Mediators

Hepatology (Baltimore, Md.), 2021-07, Vol.74 (1), p.55-71

2021

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Quantification of the hepatitis B virus cccDNA: evidence-based guidelines for monitoring the key obstacle of HBV cure

Gut, 2023-05, Vol.72 (5), p.972

2023

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Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B

Journal of medicinal chemistry, 2020-09, Vol.63 (18), p.10188-10203

2020

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Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B

Journal of hepatology, 2015-06, Vol.62 (6), p.1237-1245

2015

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Exploration of the impact of gene therapy on the lives of people with haemophilia and their families: a protocol for the mixed-methods exigency study

BMJ open, 2022-08, Vol.12 (8), p.e060351

2022

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The lived experience of a novel disruptive therapy in a group of men and boys with haemophilia A with inhibitors: Emi & Me

Health expectations : an international journal of public participation in health care and health policy, 2022-02, Vol.25 (1), p.443-454

2022

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Follicular Helper T (T FH ) Cell Targeting by TLR8 Signaling For Improving HBsAg-Specific B Cell Response In Chronic Hepatitis B Patients

Frontiers in immunology, 2021-08, Vol.12, p.735913-735913

2021

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Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells

Journal of hepatology, 2018-05, Vol.68 (5), p.912-921

2018

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Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor

The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection

“I didn’t know women could have haemophilia”: A qualitative case study

Seeing the bigger picture: Qualitative research in the Zoom ® age

Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism

Ongoing viral replication and production of infectious virus in patients with chronic hepatitis B virus suppressed below the limit of quantitation on long-term nucleos(t)ide therapy

Targeting lipid biosynthesis pathways for hepatitis B virus cure

PD-1 blockade partially recovers dysfunctional virus-specific B cells in chronic hepatitis B infection

Identifying and Characterizing Interplay between Hepatitis B Virus X Protein and Smc5/6

Barriers to gene therapy, understanding the concerns people with haemophilia have: an exigency sub-study

Therapeutic shutdown of HBV transcripts promotes reappearance of the SMC5/6 complex and silencing of the viral genome in vivo

Toll‐like receptor 7 agonist, GS‐986, is an immune‐stimulant inducing follicular helper T cells and expanding HBs antigen‐specific B cells in vitro

Smc5/6 silences episomal transcription by a three-step function

Spatiotemporal Analysis of Hepatitis B Virus X Protein in Primary Human Hepatocytes

The problem with self-management: Problematising self-management and power using a Foucauldian lens in the context of stroke care and rehabilitation

Toll‐Like Receptor 8 Agonist GS‐9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B

Therapeutic Potential of TLR8 Agonist GS‐9688 (Selgantolimod) in Chronic Hepatitis B: Remodeling of Antiviral and Regulatory Mediators

Quantification of the hepatitis B virus cccDNA: evidence-based guidelines for monitoring the key obstacle of HBV cure

Hepatitis D virus interferes with hepatitis B virus RNA production via interferon-dependent and -independent mechanisms

Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B

Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B

Exploration of the impact of gene therapy on the lives of people with haemophilia and their families: a protocol for the mixed-methods exigency study

The lived experience of a novel disruptive therapy in a group of men and boys with haemophilia A with inhibitors: Emi & Me

Follicular Helper T (T FH ) Cell Targeting by TLR8 Signaling For Improving HBsAg-Specific B Cell Response In Chronic Hepatitis B Patients

Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells

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