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Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin)

Seminars in oncology, 1999-08, Vol.26 (4 Suppl 12), p.60

1999

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Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin

The Journal of biological chemistry, 1994-05, Vol.269 (20), p.14661-14665

1994

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Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells

Oncogene, 1994-07, Vol.9 (7), p.1829-1838

1994

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Humanization of an antibody directed against IgE

The Journal of immunology (1950), 1993-09, Vol.151 (5), p.2623

1993

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Anti-transforming growth factor (TGF)-β antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity : implications for a possible role of tumor cell/host TGF-β interactions in human breast cancer progression

The Journal of clinical investigation, 1993-12, Vol.92 (6), p.2569-2576

1993

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Growth regulation of human breast and ovarian tumor cells by heregulin : Evidence for the requirement of ErbB2 as a critical component in mediating heregulin responsiveness

Cancer research (Chicago, Ill.), 1996-03, Vol.56 (6), p.1457-1465

1996

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Stimulation of human T-cell proliferation by specific activation of the 75-kDa tumor necrosis factor receptor

The Journal of immunology (1950), 1993-11, Vol.151 (9), p.4637

1993

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High resolution functional analysis of antibody-antigen interactions

Journal of molecular biology, 1992-08, Vol.226 (3), p.851-865

1992

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Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product

Cancer research (Chicago, Ill.), 1990-03, Vol.50 (5), p.1550-1558

1990

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A truncated intracellular HER2/neu receptor produced by alternative RNA processing affects growth of human carcinoma cells

Molecular and Cellular Biology, 1993-04, Vol.13 (4), p.2247-2257

1993

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Long-Term Inhibition of Tumor Growth by Tumor Necrosis Factor in the Absence of Cachexia or T-Cell Immunity

Proceedings of the National Academy of Sciences - PNAS, 1991-05, Vol.88 (9), p.3535-3539

1991

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Mapping the CD4 Binding Site for Human Immunodeficiency Virus by Alanine- Scanning Mutagenesis

Proceedings of the National Academy of Sciences - PNAS, 1990-09, Vol.87 (18), p.7150-7154

1990

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Expression of the p185 encoded by her2 oncogene in normal and transformed human tissues

International journal of cancer, 1990-03, Vol.45 (3), p.457-461

1990

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Human natriuretic peptide receptor-A guanylyl cyclase. Hormone cross-linking and antibody reactivity distinguish receptor glycoforms

The Journal of biological chemistry, 1992-10, Vol.267 (30), p.21691-21697

1992

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Biochemical properties of the 75-kDa tumor necrosis factor receptor. Characterization of ligand binding, internalization, and receptor phosphorylation

The Journal of biological chemistry, 1992-10, Vol.267 (29), p.21172-21178

1992

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Monoclonal antibody therapy of human cancer : taking the HER2 protooncogene to the clinic

Journal of clinical immunology, 1991-05, Vol.11 (3), p.117-127

1991

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Identification of cysteine-rich domains of the type 1 tumor necrosis factor receptor involved in ligand binding

The Journal of biological chemistry, 1992-03, Vol.267 (9), p.5747-5750

1992

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Recombinant Tumor Necrosis Factor Causes Activation of Human Granulocytes

Blood, 1987-02, Vol.69 (2), p.640-644

1987

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Characterization of a recombinant extracellular domain of the type 1 tumor necrosis factor receptor: evidence for tumor necrosis factor .alpha. induced receptor aggregation

Biochemistry (Easton), 1992-02, Vol.31 (4), p.1134-1141

1992

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Strain specificity and binding affinity requirements of neutralizing monoclonal antibodies to the C4 domain of gp120 from human immunodeficiency virus type 1

Journal of Virology, 1993-10, Vol.67 (10), p.6179-6191

1993

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Evidence for an autocrine role of activin B within rat anterior pituitary cultures

Endocrinology (Philadelphia), 1991-03, Vol.128 (3), p.1682-1684

1991

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Natriuretic Peptide Receptor-B (Guanylyl Cyclase-B) Mediates C-type Natriuretic Peptide Relaxation of Precontracted Rat Aorta (∗)

The Journal of biological chemistry, 1995-03, Vol.270 (9), p.4668-4674

1995

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HER2 (c-erbB-2) oncoprotein expression in colorectal adenocarcinoma: an immunohistological study using three different antibodies

Journal of clinical pathology, 1992-08, Vol.45 (8), p.726-727

1992

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Mutational Analysis of Thrombopoietin for Identification of Receptor and Neutralizing Antibody Sites

The Journal of biological chemistry, 1997-08, Vol.272 (33), p.20595-20602

1997

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Novel Non-isotopic Method for the Localization of Receptors in Tissue Sections

The journal of histochemistry and cytochemistry, 2001-12, Vol.49 (12), p.1509-1517

2001

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Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin)

Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin

Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells

Humanization of an antibody directed against IgE

Anti-transforming growth factor (TGF)-β antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity : implications for a possible role of tumor cell/host TGF-β interactions in human breast cancer progression

Growth regulation of human breast and ovarian tumor cells by heregulin : Evidence for the requirement of ErbB2 as a critical component in mediating heregulin responsiveness

Stimulation of human T-cell proliferation by specific activation of the 75-kDa tumor necrosis factor receptor

High resolution functional analysis of antibody-antigen interactions

Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product

A truncated intracellular HER2/neu receptor produced by alternative RNA processing affects growth of human carcinoma cells

Long-Term Inhibition of Tumor Growth by Tumor Necrosis Factor in the Absence of Cachexia or T-Cell Immunity

Mapping the CD4 Binding Site for Human Immunodeficiency Virus by Alanine- Scanning Mutagenesis

Expression of the p185 encoded by her2 oncogene in normal and transformed human tissues

Human natriuretic peptide receptor-A guanylyl cyclase. Hormone cross-linking and antibody reactivity distinguish receptor glycoforms

Biochemical properties of the 75-kDa tumor necrosis factor receptor. Characterization of ligand binding, internalization, and receptor phosphorylation

Monoclonal antibody therapy of human cancer : taking the HER2 protooncogene to the clinic

Identification of cysteine-rich domains of the type 1 tumor necrosis factor receptor involved in ligand binding

Recombinant Tumor Necrosis Factor Causes Activation of Human Granulocytes

Characterization of a recombinant extracellular domain of the type 1 tumor necrosis factor receptor: evidence for tumor necrosis factor .alpha. induced receptor aggregation

Strain specificity and binding affinity requirements of neutralizing monoclonal antibodies to the C4 domain of gp120 from human immunodeficiency virus type 1

Evidence for an autocrine role of activin B within rat anterior pituitary cultures

Natriuretic Peptide Receptor-B (Guanylyl Cyclase-B) Mediates C-type Natriuretic Peptide Relaxation of Precontracted Rat Aorta (∗)

HER2 (c-erbB-2) oncoprotein expression in colorectal adenocarcinoma: an immunohistological study using three different antibodies

Mutational Analysis of Thrombopoietin for Identification of Receptor and Neutralizing Antibody Sites

Novel Non-isotopic Method for the Localization of Receptors in Tissue Sections

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