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Therapeutic targeting of the angiopoietin-TIE pathway

Nature reviews. Drug discovery, 2017-09, Vol.16 (9), p.635-661

2017

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VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling

Circulation research, 2017-04, Vol.120 (9), p.1414-1425

2017

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VEGF and angiopoietin signaling in tumor angiogenesis and metastasis

Trends in molecular medicine, 2011-07, Vol.17 (7), p.347-362

2011

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Somatic Activating PIK3CA Mutations Cause Venous Malformation

American journal of human genetics, 2015-12, Vol.97 (6), p.914-921

2015

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Development of Molecular Therapies for Venous Malformations

Basic & clinical pharmacology & toxicology, 2018-09, Vol.123 (S5), p.6-19

2018

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Endothelial destabilization by angiopoietin-2 via integrin β1 activation

Nature communications, 2015-01, Vol.6 (1), p.5962-5962, Article 5962

2015

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Mouse models for studying angiogenesis and lymphangiogenesis in cancer

Molecular oncology, 2013-04, Vol.7 (2), p.259-282

2013

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Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

The Journal of clinical investigation, 2022-08, Vol.132 (15), p.1-17

2022

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VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications

Cell metabolism, 2016-04, Vol.23 (4), p.712-724

2016

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Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations

Nature genetics, 2009-01, Vol.41 (1), p.118-124

2009

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Synchronous functional magnetic resonance eye imaging, video ophthalmoscopy, and eye surface imaging reveal the human brain and eye pulsation mechanisms

Scientific reports, 2024-01, Vol.14 (1), p.2250-2250, Article 2250

2024

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Functional human cell-based vascularised cardiac tissue model for biomedical research and testing

Scientific reports, 2022-08, Vol.12 (1), p.13459-13459, Article 13459

2022

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Common and specific effects of TIE2 mutations causing venous malformations

Human molecular genetics, 2015-11, Vol.24 (22), p.6374-6389

2015

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Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell-Cell Junctions and Lung Metastasis

JNCI : Journal of the National Cancer Institute, 2012-03, Vol.104 (6), p.461-475

2012

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Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner

eLife, 2022-07, Vol.11

2022

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EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity

eLife, 2020-09, Vol.9

2020

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Angiopoietin-4-dependent venous maturation and fluid drainage in the peripheral retina

eLife, 2018-11, Vol.7

2018

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Angiopoietin signaling in the vasculature

Experimental cell research, 2013-05, Vol.319 (9), p.1271-1280

2013

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PHD2 deletion in endothelial or arterial smooth muscle cells reveals vascular cell type-specific responses in pulmonary hypertension and fibrosis

Angiogenesis (London), 2022-05, Vol.25 (2), p.259-274

2022

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Blood pressure lowering enhances cerebrospinal fluid efflux to the systemic circulation primarily via the lymphatic vasculature

Fluids and barriers of the CNS, 2024-01, Vol.21 (1), p.12-12, Article 12

2024

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VEGF‐B‐induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart

EMBO molecular medicine, 2014-03, Vol.6 (3), p.307-321

2014

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Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy

The Journal of clinical investigation, 2014-02, Vol.124 (2), p.824-834

2014

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Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems

Clinical science (1979), 2017-01, Vol.131 (1), p.87-103

2017

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Collagen XV Is Necessary for Modeling of the Extracellular Matrix and Its Deficiency Predisposes to Cardiomyopathy

Circulation research, 2010-11, Vol.107 (10), p.1241-1252

2010

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Histopathological evaluation of prostate specimens after thermal ablation may be confounded by the presence of thermally-fixed cells

International journal of hyperthermia, 2019-01, Vol.36 (1), p.914-924

2019

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Therapeutic targeting of the angiopoietin-TIE pathway

VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling

VEGF and angiopoietin signaling in tumor angiogenesis and metastasis

Somatic Activating PIK3CA Mutations Cause Venous Malformation

Development of Molecular Therapies for Venous Malformations

Endothelial destabilization by angiopoietin-2 via integrin β1 activation

Mouse models for studying angiogenesis and lymphangiogenesis in cancer

Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications

Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations

Synchronous functional magnetic resonance eye imaging, video ophthalmoscopy, and eye surface imaging reveal the human brain and eye pulsation mechanisms

Functional human cell-based vascularised cardiac tissue model for biomedical research and testing

Common and specific effects of TIE2 mutations causing venous malformations

Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell-Cell Junctions and Lung Metastasis

Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner

EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity

Angiopoietin-4-dependent venous maturation and fluid drainage in the peripheral retina

Angiopoietin signaling in the vasculature

PHD2 deletion in endothelial or arterial smooth muscle cells reveals vascular cell type-specific responses in pulmonary hypertension and fibrosis

Blood pressure lowering enhances cerebrospinal fluid efflux to the systemic circulation primarily via the lymphatic vasculature

VEGF‐B‐induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart

Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy

Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems

Collagen XV Is Necessary for Modeling of the Extracellular Matrix and Its Deficiency Predisposes to Cardiomyopathy

Histopathological evaluation of prostate specimens after thermal ablation may be confounded by the presence of thermally-fixed cells

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