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The Development of CK2 Inhibitors: From Traditional Pharmacology to in Silico Rational Drug Design

Pharmaceuticals, 2017-02, Vol.10 (1), p.26

Cozza, Giorgio

2017

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Medicinal chemistry and the molecular operating environment (MOE): application of QSAR and molecular docking to drug discovery

Current topics in medicinal chemistry, 2008-12, Vol.8 (18), p.1555

2008

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Insight into the mechanism of ferroptosis inhibition by ferrostatin-1

Redox biology, 2020-01, Vol.28, p.101328, Article 101328

2020

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Glutathione peroxidase 4-catalyzed reduction of lipid hydroperoxides in membranes: The polar head of membrane phospholipids binds the enzyme and addresses the fatty acid hydroperoxide group toward the redox center

Free radical biology & medicine, 2017-11, Vol.112, p.1-11

2017

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Monitoring Nrf2/ARE Pathway Activity with a New Zebrafish Reporter System

International journal of molecular sciences, 2023-04, Vol.24 (7), p.6804

2023

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The Acidophilic Kinases PLK2 and PLK3: Structure, Substrate Targeting and Inhibition

Current protein & peptide science, 2018-01, Vol.19 (8), p.728

2018

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Circular manufacturing ecosystems: Automotive printed circuit boards recycling as an enabler of the economic development

Production & manufacturing research, 2023-12, Vol.11 (1)

2023

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Double Attack to Oxidative Stress in Neurodegenerative Disorders: MAO-B and Nrf2 as Elected Targets

Molecules (Basel, Switzerland), 2023-11, Vol.28 (21), p.7424

2023

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Inhibition of Protein Kinase CK2 by Flavonoids and Tyrphostins. A Structural Insight

Biochemistry (Easton), 2012-08, Vol.51 (31), p.6097-6107

2012

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Unprecedented Selectivity and Structural Determinants of a New Class of Protein Kinase CK2 Inhibitors in Clinical Trials for the Treatment of Cancer

Biochemistry (Easton), 2011-10, Vol.50 (39), p.8478-8488

2011

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The selectivity of inhibitors of protein kinase CK2: an update

Biochemical journal, 2008-11, Vol.415 (3), p.353-365

2008

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From Monoamine Oxidase Inhibition to Antiproliferative Activity: New Biological Perspectives for Polyamine Analogs

Molecules (Basel, Switzerland), 2023-08, Vol.28 (17), p.6329

2023

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Role of carboxylic group pattern on protein surface in the recognition of iron oxide nanoparticles: A key for protein corona formation

International journal of biological macromolecules, 2020-12, Vol.164, p.1715-1728

2020

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Pharmacophore-guided discovery of CDC25 inhibitors causing cell cycle arrest and tumor regression

Scientific reports, 2019-02, Vol.9 (1), p.1335-1335, Article 1335

2019

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Understanding mammalian glutathione peroxidase 7 in the light of its homologs

Free radical biology & medicine, 2015-06, Vol.83, p.352-360

2015

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Production and purification of homogenous recombinant human selenoproteins reveals a unique codon skipping event in E. coli and GPX4-specific affinity to bromosulfophthalein

Redox biology, 2021-10, Vol.46, p.102070-102070, Article 102070

2021

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Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2

Biochemical journal, 2009-07, Vol.421 (3), p.387-395

2009

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Cardiolipin drives the catalytic activity of GPX4 on membranes: Insights from the R152H mutant

Redox biology, 2023-08, Vol.64, p.102806-102806, Article 102806

2023

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The importance of negative determinants as modulators of CK2 targeting. The lesson of Akt2 S131

PloS one, 2018-03, Vol.13 (3), p.e0193479-e0193479

2018

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Design, validation and efficacy of bisubstrate inhibitors specifically affecting ecto-CK2 kinase activity

Biochemical journal, 2015-11, Vol.471 (3), p.415-430

2015

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Coumarin as Attractive Casein Kinase 2 (CK2) Inhibitor Scaffold: An Integrate Approach To Elucidate the Putative Binding Motif and Explain Structure–Activity Relationships

Journal of medicinal chemistry, 2008-02, Vol.51 (4), p.752-759

2008

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Detection of phospho-sites generated by protein kinase CK2 in CFTR: mechanistic aspects of Thr1471 phosphorylation

PloS one, 2013-09, Vol.8 (9), p.e74232-e74232

2013

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The Selectivity of CK2 Inhibitor Quinalizarin: A Reevaluation

BioMed research international, 2015-01, Vol.2015, p.734127-9

2015

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An Iron Shield to Protect Epigallocatehin-3-Gallate from Degradation: Multifunctional Self-Assembled Iron Oxide Nanocarrier Enhances Protein Kinase CK2 Intracellular Targeting and Inhibition

Pharmaceutics, 2021-08, Vol.13 (8), p.1266

2021

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Science & Technology
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Life Sciences & Biomedicine
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Humans
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Biochemistry & Molecular Biology
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Animals
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Casein Kinase Ii - Antagonists & Inhibitors
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Casein Kinase Ii - Metabolism
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Kinases
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Protein Kinase Inhibitors - Pharmacology
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Proteins
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Chemistry, Medicinal
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The Development of CK2 Inhibitors: From Traditional Pharmacology to in Silico Rational Drug Design

Medicinal chemistry and the molecular operating environment (MOE): application of QSAR and molecular docking to drug discovery

Insight into the mechanism of ferroptosis inhibition by ferrostatin-1

Glutathione peroxidase 4-catalyzed reduction of lipid hydroperoxides in membranes: The polar head of membrane phospholipids binds the enzyme and addresses the fatty acid hydroperoxide group toward the redox center

Monitoring Nrf2/ARE Pathway Activity with a New Zebrafish Reporter System

The Acidophilic Kinases PLK2 and PLK3: Structure, Substrate Targeting and Inhibition

Circular manufacturing ecosystems: Automotive printed circuit boards recycling as an enabler of the economic development

Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma

Double Attack to Oxidative Stress in Neurodegenerative Disorders: MAO-B and Nrf2 as Elected Targets

Inhibition of Protein Kinase CK2 by Flavonoids and Tyrphostins. A Structural Insight

Unprecedented Selectivity and Structural Determinants of a New Class of Protein Kinase CK2 Inhibitors in Clinical Trials for the Treatment of Cancer

The selectivity of inhibitors of protein kinase CK2: an update

From Monoamine Oxidase Inhibition to Antiproliferative Activity: New Biological Perspectives for Polyamine Analogs

Role of carboxylic group pattern on protein surface in the recognition of iron oxide nanoparticles: A key for protein corona formation

Pharmacophore-guided discovery of CDC25 inhibitors causing cell cycle arrest and tumor regression

Understanding mammalian glutathione peroxidase 7 in the light of its homologs

Production and purification of homogenous recombinant human selenoproteins reveals a unique codon skipping event in E. coli and GPX4-specific affinity to bromosulfophthalein

Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2

Cardiolipin drives the catalytic activity of GPX4 on membranes: Insights from the R152H mutant

The importance of negative determinants as modulators of CK2 targeting. The lesson of Akt2 S131

Design, validation and efficacy of bisubstrate inhibitors specifically affecting ecto-CK2 kinase activity

Coumarin as Attractive Casein Kinase 2 (CK2) Inhibitor Scaffold: An Integrate Approach To Elucidate the Putative Binding Motif and Explain Structure–Activity Relationships

Detection of phospho-sites generated by protein kinase CK2 in CFTR: mechanistic aspects of Thr1471 phosphorylation

The Selectivity of CK2 Inhibitor Quinalizarin: A Reevaluation

An Iron Shield to Protect Epigallocatehin-3-Gallate from Degradation: Multifunctional Self-Assembled Iron Oxide Nanocarrier Enhances Protein Kinase CK2 Intracellular Targeting and Inhibition

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