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Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs

Nucleic acids research, 2018-02, Vol.46 (4), p.1584

2018

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Chemical modification: the key to clinical application of RNA interference?

The Journal of clinical investigation, 2007-12, Vol.117 (12), p.3615-3622

Corey, David R

2007

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Silencing disease genes in the laboratory and the clinic

The Journal of pathology, 2012-01, Vol.226 (2), p.365-379

2012

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Single-Stranded RNAs Use RNAi to Potently and Allele-Selectively Inhibit Mutant Huntingtin Expression

Cell, 2012-08, Vol.150 (5), p.895-908

2012

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RNAi factors are present and active in human cell nuclei

Cell reports (Cambridge), 2014-01, Vol.6 (1), p.211-221

2014

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Activating frataxin expression by repeat-targeted nucleic acids

Nature communications, 2016-02, Vol.7 (1), p.10606-8, Article 10606

2016

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Regulation of mammalian transcription and splicing by Nuclear RNAi

Nucleic acids research, 2016-01, Vol.44 (2), p.524

2016

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Analysis of nuclear RNA interference in human cells by subcellular fractionation and Argonaute loading

Nature protocols, 2014-09, Vol.9 (9), p.2045-2060

2014

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Non-coding RNAs as drug targets

Nature reviews. Drug discovery, 2017-03, Vol.16 (3), p.167-179

2017

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Promoter RNA links transcriptional regulation of inflammatory pathway genes

Nucleic acids research, 2013-12, Vol.41 (22), p.10086

2013

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Stable association of RNAi machinery is conserved between the cytoplasm and nucleus of human cells

RNA (Cambridge), 2016-07, Vol.22 (7), p.1085-1098

2016

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Targeting 3' and 5' untranslated regions with antisense oligonucleotides to stabilize frataxin mRNA and increase protein expression

Nucleic acids research, 2021-11, Vol.49 (20), p.11560

2021

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Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter

Nucleic acids research, 2010-11, Vol.38 (21), p.7736

2010

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Nuclear localization of Argonaute 2 is affected by cell density and may relieve repression by microRNAs

Nucleic acids research, 2024-02, Vol.52 (4), p.1930

2024

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Reexamining assumptions about miRNA-guided gene silencing

Nucleic acids research, 2022-01, Vol.50 (2), p.617

2022

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Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs

Nature biotechnology, 2009-05, Vol.27 (5), p.478-484

2009

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Difficulties translating antisense-mediated activation of Frataxin expression from cell culture to mice

RNA biology, 2022-12, Vol.19 (1), p.364-372

2022

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HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing

Molecular cell, 2016-08, Vol.63 (3), p.420-432

2016

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Stepping toward therapeutic CRISPR

Proceedings of the National Academy of Sciences - PNAS, 2015-12, Vol.112 (51), p.15536-15537

2015

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RNA Interference in Mammalian Cells by Chemically-Modified RNA

Biochemistry (Easton), 2003-07, Vol.42 (26), p.7967-7975

2003

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Recognition of c9orf72 Mutant RNA by Single-Stranded Silencing RNAs

Nucleic acid therapeutics, 2017-04, Vol.27 (2), p.87

2017

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Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription

Cell reports (Cambridge), 2017-08, Vol.20 (7), p.1543-1552

2017

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Transcriptional regulation by small RNAs at sequences downstream from 3' gene termini

Nature chemical biology, 2010-08, Vol.6 (8), p.621

2010

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ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy

Nucleic acids research, 2013-11, Vol.41 (20), p.9570

2013

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Targeting RNA with synthetic oligonucleotides: Clinical success invites new challenges

Cell chemical biology, 2024-01, Vol.31 (1), p.125-138

2024

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Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs

Chemical modification: the key to clinical application of RNA interference?

Silencing disease genes in the laboratory and the clinic

Single-Stranded RNAs Use RNAi to Potently and Allele-Selectively Inhibit Mutant Huntingtin Expression

RNAi factors are present and active in human cell nuclei

Activating frataxin expression by repeat-targeted nucleic acids

Regulation of mammalian transcription and splicing by Nuclear RNAi

Analysis of nuclear RNA interference in human cells by subcellular fractionation and Argonaute loading

Non-coding RNAs as drug targets

Promoter RNA links transcriptional regulation of inflammatory pathway genes

Stable association of RNAi machinery is conserved between the cytoplasm and nucleus of human cells

Targeting 3' and 5' untranslated regions with antisense oligonucleotides to stabilize frataxin mRNA and increase protein expression

Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter

Nuclear localization of Argonaute 2 is affected by cell density and may relieve repression by microRNAs

Reexamining assumptions about miRNA-guided gene silencing

Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs

Difficulties translating antisense-mediated activation of Frataxin expression from cell culture to mice

HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing

Stepping toward therapeutic CRISPR

RNA Interference in Mammalian Cells by Chemically-Modified RNA

Recognition of c9orf72 Mutant RNA by Single-Stranded Silencing RNAs

Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription

Transcriptional regulation by small RNAs at sequences downstream from 3' gene termini

ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy

Targeting RNA with synthetic oligonucleotides: Clinical success invites new challenges

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