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Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation

Reviews in endocrine & metabolic disorders, 2020-12, Vol.21 (4), p.431-447

2020

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Isoform-specific antagonists of exchange proteins directly activated by cAMP

Proceedings of the National Academy of Sciences - PNAS, 2012-11, Vol.109 (45), p.18613-18618

2012

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Cell physiology of cAMP sensor Epac

The Journal of physiology, 2006-11, Vol.577 (1), p.5-15

2006

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A peptide triple agonist of GLP-1, neuropeptide Y1, and neuropeptide Y2 receptors promotes glycemic control and weight loss

Scientific reports, 2023-06, Vol.13 (1), p.9554-9554, Article 9554

2023

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Identification and Characterization of Small Molecules as Potent and Specific EPAC2 Antagonists

Journal of medicinal chemistry, 2013-02, Vol.56 (3), p.952-962

2013

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Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis

Cell reports (Cambridge), 2020-06, Vol.31 (11), p.107768-107768, Article 107768

2020

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Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion

Molecular endocrinology (Baltimore, Md.), 2015-07, Vol.29 (7), p.988-1005

2015

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Nonpeptidic Z360-Analogs Tagged with Trivalent Radiometals as Anti-CCK2R Cancer Theranostic Agents: A Preclinical Study

Pharmaceutics, 2022-03, Vol.14 (3), p.666

2022

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Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag

Molecular endocrinology (Baltimore, Md.), 2013-08, Vol.27 (8), p.1267-1282

2013

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Epac2-Dependent Rap1 Activation and the Control of Islet Insulin Secretion by Glucagon-Like Peptide-1

Incretins and Insulin Secretion, 2010, Vol.84, p.279-302

2010

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Intra-islet glucagon confers β-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon

The Journal of biological chemistry, 2022-02, Vol.298 (2), p.101484-101484, Article 101484

2022

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Regulation of Glucose Homeostasis by GLP-1

Progress in Molecular Biology and Translational Science, 2014, Vol.121, p.23-65

2014

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A novel cyclic adenosine monophosphate responsive luciferase reporter incorporating a nonpalindromic cyclic adenosine monophosphate response element provides optimal performance for use in G protein coupled receptor drug discovery efforts

Journal of biomolecular screening, 2007-08, Vol.12 (5), p.740-746

2007

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PI3 kinases p110 α and PI3K-C2 β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets

Molecular metabolism (Germany), 2016-07, Vol.5 (7), p.459-471

2016

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Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans

Islets, 2011-05, Vol.3 (3), p.121-128

2011

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Restoration of Glucose-Stimulated Cdc42-Pak1 Activation and Insulin Secretion by a Selective Epac Activator in Type 2 Diabetic Human Islets

Diabetes (New York, N.Y.), 2018-10, Vol.67 (10), p.1999-2011

2018

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Epac-selective cAMP analogs: New tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors

Cellular signalling, 2008-01, Vol.20 (1), p.10-20

2008

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The alpha‐7 nicotinic acetylcholine receptor agonist GTS‐21 engages the glucagon‐like peptide‐1 incretin hormone axis to lower levels of blood glucose in db/db mice

Diabetes, obesity & metabolism, 2022-07, Vol.24 (7), p.1255-1266

2022

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Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP

The Journal of biological chemistry, 2019-03, Vol.294 (10), p.3514-3531

2019

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Corrination mitigates peptide aggregation as exemplified for Glucagon

Peptides (New York, N.Y. : 1980), 2024-01, Vol.171, p.171134-171134, Article 171134

2024

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“A-kinase” regulator runs amok to provide a paradigm shift in cAMP signaling

The Journal of biological chemistry, 2019-02, Vol.294 (7), p.2247-2248

2019

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Design and Evaluation of Peptide Dual-Agonists of GLP‑1 and NPY2 Receptors for Glucoregulation and Weight Loss with Mitigated Nausea and Emesis

Journal of medicinal chemistry, 2021-01, Vol.64 (2), p.1127-1138

2021

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Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways

Cell metabolism, 2023-07, Vol.35 (7), p.1242-1260.e9

2023

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Cyclic AMP‐dependent activation of ERK via GLP‐1 receptor signalling requires the neuroendocrine cell‐specific guanine nucleotide exchanger NCS‐RapGEF2

Journal of neuroendocrinology, 2021-07, Vol.33 (7), p.e12974-n/a

2021

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[99mTc]Tc-DGA1, a Promising CCK2R‑Antagonist-Based Tracer for Tumor Diagnosis with Single-Photon Emission Computed Tomography

Molecular pharmaceutics, 2020-08, Vol.17 (8), p.3116-3128

2020

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Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation

Isoform-specific antagonists of exchange proteins directly activated by cAMP

Cell physiology of cAMP sensor Epac

A peptide triple agonist of GLP-1, neuropeptide Y1, and neuropeptide Y2 receptors promotes glycemic control and weight loss

Identification and Characterization of Small Molecules as Potent and Specific EPAC2 Antagonists

Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis

Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion

Nonpeptidic Z360-Analogs Tagged with Trivalent Radiometals as Anti-CCK2R Cancer Theranostic Agents: A Preclinical Study

Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag

Epac2-Dependent Rap1 Activation and the Control of Islet Insulin Secretion by Glucagon-Like Peptide-1

Intra-islet glucagon confers β-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon

Regulation of Glucose Homeostasis by GLP-1

A novel cyclic adenosine monophosphate responsive luciferase reporter incorporating a nonpalindromic cyclic adenosine monophosphate response element provides optimal performance for use in G protein coupled receptor drug discovery efforts

PI3 kinases p110 α and PI3K-C2 β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets

Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans

Restoration of Glucose-Stimulated Cdc42-Pak1 Activation and Insulin Secretion by a Selective Epac Activator in Type 2 Diabetic Human Islets

Epac-selective cAMP analogs: New tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors

The alpha‐7 nicotinic acetylcholine receptor agonist GTS‐21 engages the glucagon‐like peptide‐1 incretin hormone axis to lower levels of blood glucose in db/db mice

Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP

Corrination mitigates peptide aggregation as exemplified for Glucagon

“A-kinase” regulator runs amok to provide a paradigm shift in cAMP signaling

Design and Evaluation of Peptide Dual-Agonists of GLP‑1 and NPY2 Receptors for Glucoregulation and Weight Loss with Mitigated Nausea and Emesis

Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways

Cyclic AMP‐dependent activation of ERK via GLP‐1 receptor signalling requires the neuroendocrine cell‐specific guanine nucleotide exchanger NCS‐RapGEF2

[99mTc]Tc-DGA1, a Promising CCK2R‑Antagonist-Based Tracer for Tumor Diagnosis with Single-Photon Emission Computed Tomography

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