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R-Modafinil (Armodafinil): A Unique Dopamine Uptake Inhibitor and Potential Medication for Psychostimulant Abuse

Biological psychiatry (1969), 2012-09, Vol.72 (5), p.405-413

2012

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Translating the atypical dopamine uptake inhibitor hypothesis toward therapeutics for treatment of psychostimulant use disorders

Neuropsychopharmacology (New York, N.Y.), 2019-07, Vol.44 (8), p.1435-1444

2019

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Interactions of calmodulin kinase II with the dopamine transporter facilitate cocaine-induced enhancement of evoked dopamine release

Translational psychiatry, 2023-06, Vol.13 (1), p.202-202, Article 202

2023

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Relationship between Conformational Changes in the Dopamine Transporter and Cocaine-Like Subjective Effects of Uptake Inhibitors

Molecular pharmacology, 2008-03, Vol.73 (3), p.813-823

2008

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Dopamine agonist-induced yawning in rats: a dopamine D3 receptor-mediated behavior

The Journal of pharmacology and experimental therapeutics, 2005-07, Vol.314 (1), p.310-319

2005

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Structure−Activity Relationships Comparing N-(6-Methylpyridin-yl)-Substituted Aryl Amides to 2-Methyl-6-(substituted-arylethynyl)pyridines or 2-Methyl-4-(substituted-arylethynyl)thiazoles as Novel Metabotropic Glutamate Receptor Subtype 5 Antagonists

Journal of medicinal chemistry, 2009-06, Vol.52 (11), p.3563-3575

2009

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Characterization of the transport, metabolism, and pharmacokinetics of the dopamine D3 receptor-selective fluorenyl- and 2-pyridylphenyl amides developed for treatment of psychostimulant abuse

The Journal of pharmacology and experimental therapeutics, 2010-06, Vol.333 (3), p.854-864

2010

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Progress in agonist therapy for substance use disorders: Lessons learned from methadone and buprenorphine

Neuropharmacology, 2019-11, Vol.158, p.107609-107609, Article 107609

2019

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N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl}arylcarboxamides as novel dopamine D3 receptor antagonists

Bioorganic & medicinal chemistry letters, 2003-07, Vol.13 (13), p.2179-2183

2003

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Evaluation of the blood-brain barrier transport, population pharmacokinetics, and brain distribution of benztropine analogs and cocaine using in vitro and in vivo techniques

The Journal of pharmacology and experimental therapeutics, 2003-11, Vol.307 (2), p.801-808

2003

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Structure−Activity Relationship Studies on a Novel Series of (S)-2β-Substituted 3α-[Bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane Analogues for in Vivo Investigation

Journal of medicinal chemistry, 2006-10, Vol.49 (21), p.6391-6399

2006

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Molecular Determinants of Selectivity and Efficacy at the Dopamine D3 Receptor

Journal of medicinal chemistry, 2012-08, Vol.55 (15), p.6689-6699

2012

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Dopamine D3R antagonist VK4-116 attenuates oxycodone self-administration and reinstatement without compromising its antinociceptive effects

Neuropsychopharmacology (New York, N.Y.), 2019-07, Vol.44 (8), p.1415-1424

2019

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Structure Activity Relationships for a Series of Eticlopride-Based Dopamine D 2 /D 3 Receptor Bitopic Ligands

Journal of medicinal chemistry, 2021-10, Vol.64 (20), p.15313-15333

2021

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The highly selective dopamine D3R antagonist, R-VK4-40 attenuates oxycodone reward and augments analgesia in rodents

Neuropharmacology, 2019-11, Vol.158, p.107597-107597, Article 107597

2019

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The novel dopamine D3 receptor antagonists/partial agonists CAB2-015 and BAK4-54 inhibit oxycodone-taking and oxycodone-seeking behavior in rats

Neuropharmacology, 2017-11, Vol.126, p.190-199

2017

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3,4-Methylenedioxypyrovalerone High-Responder Phenotype as a Tool to Evaluate Candidate Medications for Stimulant Use Disorder

The Journal of pharmacology and experimental therapeutics, 2023-03, Vol.384 (3), p.353-362

2023

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Atypical dopamine transporter inhibitors R-modafinil and JHW 007 differentially affect D2 autoreceptor neurotransmission and the firing rate of midbrain dopamine neurons

Neuropharmacology, 2017-09, Vol.123, p.410-419

2017

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The Effects of the Dopamine Transporter Ligands JJC8-088 and JJC8-091 on Cocaine versus Food Choice in Rhesus Monkeys

The Journal of pharmacology and experimental therapeutics, 2023-03, Vol.384 (3), p.372-381

2023

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Potential therapeutics for effort-related motivational dysfunction: assessing novel atypical dopamine transport inhibitors

Neuropsychopharmacology (New York, N.Y.), 2024-07, Vol.49 (8), p.1309-1317

2024

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Modifications to 1‑(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile

Journal of medicinal chemistry, 2024-01, Vol.67 (1), p.709-727

2024

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Design and Synthesis of a Novel Photoaffinity Ligand for the Dopamine and Serotonin Transporters Based on 2β-Carbomethoxy-3β-biphenyltropane

Journal of medicinal chemistry, 2006-11, Vol.49 (22), p.6621-6625

2006

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Dual DAT and sigma receptor inhibitors attenuate cocaine effects on nucleus accumbens dopamine dynamics in rats

The European journal of neuroscience, 2024-05, Vol.59 (10), p.2436-2449

2024

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Dual Probes for the Dopamine Transporter and σ1 Receptors: Novel Piperazinyl Alkyl-bis(4‘-fluorophenyl)amine Analogues as Potential Cocaine-Abuse Therapeutic Agents

Journal of medicinal chemistry, 2003-06, Vol.46 (13), p.2589-2598

2003

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Novel Dual-Target μ-Opioid Receptor and Dopamine D 3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management

Journal of medicinal chemistry, 2021-06, Vol.64 (11), p.7778-7808

2021

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R-Modafinil (Armodafinil): A Unique Dopamine Uptake Inhibitor and Potential Medication for Psychostimulant Abuse

Translating the atypical dopamine uptake inhibitor hypothesis toward therapeutics for treatment of psychostimulant use disorders

Interactions of calmodulin kinase II with the dopamine transporter facilitate cocaine-induced enhancement of evoked dopamine release

Relationship between Conformational Changes in the Dopamine Transporter and Cocaine-Like Subjective Effects of Uptake Inhibitors

Dopamine agonist-induced yawning in rats: a dopamine D3 receptor-mediated behavior

Structure−Activity Relationships Comparing N-(6-Methylpyridin-yl)-Substituted Aryl Amides to 2-Methyl-6-(substituted-arylethynyl)pyridines or 2-Methyl-4-(substituted-arylethynyl)thiazoles as Novel Metabotropic Glutamate Receptor Subtype 5 Antagonists

Characterization of the transport, metabolism, and pharmacokinetics of the dopamine D3 receptor-selective fluorenyl- and 2-pyridylphenyl amides developed for treatment of psychostimulant abuse

Progress in agonist therapy for substance use disorders: Lessons learned from methadone and buprenorphine

N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl}arylcarboxamides as novel dopamine D3 receptor antagonists

Evaluation of the blood-brain barrier transport, population pharmacokinetics, and brain distribution of benztropine analogs and cocaine using in vitro and in vivo techniques

Structure−Activity Relationship Studies on a Novel Series of (S)-2β-Substituted 3α-[Bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane Analogues for in Vivo Investigation

Molecular Determinants of Selectivity and Efficacy at the Dopamine D3 Receptor

Dopamine D3R antagonist VK4-116 attenuates oxycodone self-administration and reinstatement without compromising its antinociceptive effects

Structure Activity Relationships for a Series of Eticlopride-Based Dopamine D 2 /D 3 Receptor Bitopic Ligands

The highly selective dopamine D3R antagonist, R-VK4-40 attenuates oxycodone reward and augments analgesia in rodents

The novel dopamine D3 receptor antagonists/partial agonists CAB2-015 and BAK4-54 inhibit oxycodone-taking and oxycodone-seeking behavior in rats

3,4-Methylenedioxypyrovalerone High-Responder Phenotype as a Tool to Evaluate Candidate Medications for Stimulant Use Disorder

Atypical dopamine transporter inhibitors R-modafinil and JHW 007 differentially affect D2 autoreceptor neurotransmission and the firing rate of midbrain dopamine neurons

The Effects of the Dopamine Transporter Ligands JJC8-088 and JJC8-091 on Cocaine versus Food Choice in Rhesus Monkeys

Potential therapeutics for effort-related motivational dysfunction: assessing novel atypical dopamine transport inhibitors

Modifications to 1‑(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile

Design and Synthesis of a Novel Photoaffinity Ligand for the Dopamine and Serotonin Transporters Based on 2β-Carbomethoxy-3β-biphenyltropane

Dual DAT and sigma receptor inhibitors attenuate cocaine effects on nucleus accumbens dopamine dynamics in rats

Dual Probes for the Dopamine Transporter and σ1 Receptors: Novel Piperazinyl Alkyl-bis(4‘-fluorophenyl)amine Analogues as Potential Cocaine-Abuse Therapeutic Agents

Novel Dual-Target μ-Opioid Receptor and Dopamine D 3 Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management

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