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Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

Frontiers in oncology, 2016-02, Vol.6, p.21-21

2016

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Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound

Nature medicine, 2002-03, Vol.8 (3), p.282-288

2002

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Mutant p53 reactivation by small molecules makes its way to the clinic

FEBS letters, 2014-08, Vol.588 (16), p.2622-2627

2014

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Mutant p53 targeting by the low molecular weight compound STIMA‐1

Molecular oncology, 2017-05, Vol.11 (5), p.595-595

2017

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Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer

Journal of clinical oncology, 2012-10, Vol.30 (29), p.3633-3639

2012

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Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

Scientific reports, 2018-08, Vol.8 (1), p.12671-10, Article 12671

2018

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PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

Cancer cell, 2009-05, Vol.15 (5), p.376-388

2009

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In vitro and in vivo cytotoxic effects of PRIMA-1 on hepatocellular carcinoma cells expressing mutant p53ser249

Carcinogenesis (New York), 2008-07, Vol.29 (7), p.1428-1434

2008

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Needling With 5-Fluorouracil (5-FU) After XEN Gel Stent Implantation: 6-Month Outcomes

Journal of glaucoma, 2018-10, Vol.27 (10), p.893-899

2018

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Novel compounds that synergize with aminoglycoside G418 or eRF3 degraders for translational readthrough of nonsense mutant TP53 and PTEN

RNA biology, 2023, Vol.20 (1), p.368-383

2023

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Reactivation of Mutant p53 and Induction of Apoptosis in Human Tumor Cells by Maleimide Analogs

The Journal of biological chemistry, 2005-08, Vol.280 (34), p.30384-30391

2005

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The Mutant p53-Targeting Compound APR-246 Induces ROS-Modulating Genes in Breast Cancer Cells

Translational oncology, 2018-12, Vol.11 (6), p.1343-1349

2018

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Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors

Frontiers in oncology, 2018-01, Vol.7, p.323-323

2018

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Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database

Carcinogenesis (New York), 2002-12, Vol.23 (12), p.2011-2018

2002

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Mutant p53 rescue and modulation of p53 redox state

Cell cycle (Georgetown, Tex.), 2009-08, Vol.8 (16), p.2509-2517

2009

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Mutant p53 targeting by the low molecular weight compound STIMA-1

Molecular oncology, 2008-06, Vol.2 (1), p.70-80

2008

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Use of the Prostatype P-score to predict adverse pathology (AP) at radical prostatectomy (RP)

Journal of clinical oncology, 2024-02, Vol.42 (4_suppl), p.276-276

2024

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APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

Cell death & disease, 2018-04, Vol.9 (5), p.439-12, Article 439

2018

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The p53 tumor suppressor: A master regulator of diverse cellular processes and therapeutic target in cancer

Biochemical and biophysical research communications, 2010-05, Vol.396 (1), p.85-89

2010

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Pharmacological induction of translational readthrough of nonsense mutations in the retinoblastoma (RB1) gene

PloS one, 2023-11, Vol.18 (11), p.e0292468-e0292468

2023

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Role of Thiol Reactivity for Targeting Mutant p53

Cell chemical biology, 2018-10, Vol.25 (10), p.1219-1230.e3

2018

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Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5-Fluorouridine

Cell death & disease, 2022-11, Vol.13 (11), p.997-997, Article 997

2022

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A thiol‐bound drug reservoir enhances APR‐246‐induced mutant p53 tumor cell death

EMBO molecular medicine, 2021-02, Vol.13 (2), p.e10852-n/a

2021

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Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

Cell death & disease, 2021-07, Vol.12 (7), p.709-10, Article 709

2021

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Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs

The Journal of biological chemistry, 2017-12, Vol.292 (48), p.19607-19607

2017

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Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound

Mutant p53 reactivation by small molecules makes its way to the clinic

Mutant p53 targeting by the low molecular weight compound STIMA‐1

Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

In vitro and in vivo cytotoxic effects of PRIMA-1 on hepatocellular carcinoma cells expressing mutant p53ser249

Needling With 5-Fluorouracil (5-FU) After XEN Gel Stent Implantation: 6-Month Outcomes

Novel compounds that synergize with aminoglycoside G418 or eRF3 degraders for translational readthrough of nonsense mutant TP53 and PTEN

Reactivation of Mutant p53 and Induction of Apoptosis in Human Tumor Cells by Maleimide Analogs

The Mutant p53-Targeting Compound APR-246 Induces ROS-Modulating Genes in Breast Cancer Cells

Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors

Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database

Mutant p53 rescue and modulation of p53 redox state

Mutant p53 targeting by the low molecular weight compound STIMA-1

Use of the Prostatype P-score to predict adverse pathology (AP) at radical prostatectomy (RP)

APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

The p53 tumor suppressor: A master regulator of diverse cellular processes and therapeutic target in cancer

Pharmacological induction of translational readthrough of nonsense mutations in the retinoblastoma (RB1) gene

Role of Thiol Reactivity for Targeting Mutant p53

Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5-Fluorouridine

A thiol‐bound drug reservoir enhances APR‐246‐induced mutant p53 tumor cell death

Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs

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