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Design, Structure–Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2‑b]pyridazines as Glycogen Synthase Kinase-3β (GSK-3β) Inhibitors

Journal of medicinal chemistry, 2023-03, Vol.66 (6), p.4231-4252

2023

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Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core

Bioorganic & medicinal chemistry letters, 2015-05, Vol.25 (9), p.1856-1863

2015

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Structure–activity relationship (SAR) studies on substituted N-(pyridin-3-yl)-2-amino-isonicotinamides as highly potent and selective glycogen synthase kinase-3 (GSK-3) inhibitors

Bioorganic & medicinal chemistry letters, 2023-02, Vol.81, p.129143-129143, Article 129143

2023

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Discovery of 2‑(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase‑3 (GSK-3) Inhibitors

Journal of medicinal chemistry, 2023-06, Vol.66 (11), p.7534-7552

2023

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Assigning Cytomegalovirus Status in Children Awaiting Organ Transplant: Viral Shedding, CMV-Specific T Cells, and CD27-CD28-CD4+ T Cells

The Journal of infectious diseases, 2018-09, Vol.218 (8), p.1205-1209

2018

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Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase‑3 Inhibitors

Journal of medicinal chemistry, 2016-02, Vol.59 (3), p.1041-1051

2016

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Functional Abilities in Older Adults with Mild Cognitive Impairment

Gerontology (Basel), 2009-09, Vol.55 (5), p.570-581

2009

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CMV-specific T-cells and CD27-CD28-CD4+ T-cells for assignment of cytomegalovirus (CMV) status in adults awaiting organ transplant

Journal of clinical virology, 2019-06, Vol.115, p.37-42

2019

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Live vaccines after pediatric solid organ transplant: Proceedings of a consensus meeting, 2018

Pediatric transplantation, 2019-11, Vol.23 (7), p.e13571-n/a

2019

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Gaps in knowledge about the vaccine coverage of immunocompromised children: a scoping review

Human vaccines & immunotherapeutics, 2022-12, Vol.18 (1), p.1-16

2022

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Assignment of cytomegalovirus infection status in infants awaiting solid organ transplant: Viral detection methods as adjuncts to serology

Pediatric transplantation, 2018-08, Vol.22 (5), p.e13229-n/a

2018

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The effect of the COVID-19 pandemic on influenza-related hospitalization, intensive care admission and mortality in children in Canada: A population-based study

Lancet Regional Health - Americas (Online), 2022-03, Vol.7, p.100132-100132, Article 100132

2022

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Cognitive Functioning and Everyday Problem Solving in Older Adults

Clinical neuropsychologist, 2006-09, Vol.20 (3), p.432-452

2006

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The role of PET imaging in lymphoma

British journal of haematology, 2004-09, Vol.126 (6), p.772-784

2004

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Acyl Guanidine Inhibitors of β‑Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9208-9223

2012

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Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor

ACS medicinal chemistry letters, 2010-06, Vol.1 (3), p.120-124

2010

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Intraindividual Variability as a Marker of Neurological Dysfunction: A Comparison of Alzheimer's Disease and Parkinson's Disease

Journal of clinical and experimental neuropsychology, 2006-01, Vol.28 (1), p.67-83

2006

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Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ‑Secretase Modulator BMS-932481

ACS medicinal chemistry letters, 2019-03, Vol.10 (3), p.312-317

2019

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Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)

Bioorganic & medicinal chemistry letters, 2015-11, Vol.25 (22), p.5040-5047

2015

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Synthesis and Biological Evaluation of 1-Aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one Inhibitors of Cyclin-Dependent Kinases

Journal of medicinal chemistry, 2004-11, Vol.47 (24), p.5894-5911

2004

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Switch from inhibitory to activating NKG2 receptor expression in HIV-1 infection : lack of reversion with highly active antiretroviral therapy

AIDS (London), 2005-11, Vol.19 (16), p.1761-1769

2005

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The Amyloid-β Rise and γ-Secretase Inhibitor Potency Depend on the Level of Substrate Expression

The Journal of biological chemistry, 2008-08, Vol.283 (34), p.22992-23003

2008

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A large-group peer mentoring programme in an under-resourced higher education environment

International journal of mentoring and coaching in education, 2020-11, Vol.9 (4), p.341-356

2020

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The Relationship between Everyday Problem Solving and Inconsistency in Reaction Time in Older Adults

Aging, Neuropsychology, and Cognition, 2009-09, Vol.16 (5), p.607-632

2009

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Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 2. Probing the Indeno Ring Substituent Pattern

Journal of medicinal chemistry, 2002-11, Vol.45 (24), p.5224-5232

2002

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Design, Structure–Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2‑b]pyridazines as Glycogen Synthase Kinase-3β (GSK-3β) Inhibitors

Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core

Structure–activity relationship (SAR) studies on substituted N-(pyridin-3-yl)-2-amino-isonicotinamides as highly potent and selective glycogen synthase kinase-3 (GSK-3) inhibitors

Discovery of 2‑(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase‑3 (GSK-3) Inhibitors

Assigning Cytomegalovirus Status in Children Awaiting Organ Transplant: Viral Shedding, CMV-Specific T Cells, and CD27-CD28-CD4+ T Cells

Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase‑3 Inhibitors

Functional Abilities in Older Adults with Mild Cognitive Impairment

CMV-specific T-cells and CD27-CD28-CD4+ T-cells for assignment of cytomegalovirus (CMV) status in adults awaiting organ transplant

Live vaccines after pediatric solid organ transplant: Proceedings of a consensus meeting, 2018

Gaps in knowledge about the vaccine coverage of immunocompromised children: a scoping review

Assignment of cytomegalovirus infection status in infants awaiting solid organ transplant: Viral detection methods as adjuncts to serology

The effect of the COVID-19 pandemic on influenza-related hospitalization, intensive care admission and mortality in children in Canada: A population-based study

Cognitive Functioning and Everyday Problem Solving in Older Adults

The role of PET imaging in lymphoma

Acyl Guanidine Inhibitors of β‑Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor

Intraindividual Variability as a Marker of Neurological Dysfunction: A Comparison of Alzheimer's Disease and Parkinson's Disease

Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ‑Secretase Modulator BMS-932481

Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)

Synthesis and Biological Evaluation of 1-Aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one Inhibitors of Cyclin-Dependent Kinases

Switch from inhibitory to activating NKG2 receptor expression in HIV-1 infection : lack of reversion with highly active antiretroviral therapy

The Amyloid-β Rise and γ-Secretase Inhibitor Potency Depend on the Level of Substrate Expression

A large-group peer mentoring programme in an under-resourced higher education environment

The Relationship between Everyday Problem Solving and Inconsistency in Reaction Time in Older Adults

Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 2. Probing the Indeno Ring Substituent Pattern

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