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Presenilin function and γ‐secretase activity

Journal of neurochemistry, 2005-05, Vol.93 (4), p.769-792

2005

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Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and γ‐secretase activity

Journal of neurochemistry, 2005-09, Vol.94 (5), p.1315-1328

2005

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A domain at the C‐terminus of PS1 is required for presenilinase and γ‐secretase activities

Journal of neurochemistry, 2005-03, Vol.92 (5), p.1158-1169

2005

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Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Aβ 42/40 ratios

Journal of neurochemistry, 2005-01, Vol.92 (2), p.294-301

2005

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A Presenilin Dimer at the Core of the γ-Secretase Enzyme: Insights from Parallel Analysis of Notch 1 and APP Proteolysis

Proceedings of the National Academy of Sciences - PNAS, 2003-10, Vol.100 (22), p.13075-13080

2003

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Conserved “PAL” sequence in presenilins is essential for γ-secretase activity, but not required for formation or stabilization of γ-secretase complexes

Neurobiology of disease, 2004-04, Vol.15 (3), p.654-666

2004

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Presenilin endoproteolysis is an intramolecular cleavage

Molecular and cellular neuroscience, 2005-05, Vol.29 (1), p.65-73

2005

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Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and [gamma]-secretase activity

Journal of neurochemistry, 2005-09, Vol.94 (5), p.1315

2005

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Presenilin-1 Protects against Neuronal Apoptosis Caused by Its Interacting Protein PAG

Neurobiology of disease, 2002-03, Vol.9 (2), p.126-138

2002

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Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein

Nature, 2006-11, Vol.444 (7116), p.226-229

2006

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Gene expression profiling of gastrin target genes in parietal cells

Physiological genomics, 2006-01, Vol.24 (2), p.124-132

2006

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Intestinal Neurogenin 3 directs differentiation of a bipotential secretory progenitor to endocrine cell rather than goblet cell fate

Developmental biology, 2007-09, Vol.309 (2), p.298-305

2007

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Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic mice

American journal of physiology: Gastrointestinal and liver physiology, 2006-05, Vol.290 (5), p.G970-G979

2006

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Structure–function relationships of the outer membrane translocon Wza investigated by cryo-electron microscopy and mutagenesis

Journal of structural biology, 2009-05, Vol.166 (2), p.172-182

2009

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Enteroendocrine cell expression of a cholecystokinin gene construct in transgenic mice and cultured cells

American journal of physiology: Gastrointestinal and liver physiology, 2005-02, Vol.288 (2), p.G354-G361

2005

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Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios

Journal of neurochemistry, 2005-01, Vol.92 (2), p.294-301

2005

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Neurogenin 3 overexpression in transgenic mouse intestine promotes endocrine cell development

The FASEB journal, 2006-03, Vol.20 (5), p.A1273-A1273

2006

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Transgenic overexpression of Neurogenin 3 in the intestine promotes endocrine cell development to the detriment of goblet cells

The FASEB journal, 2007, Vol.21 (6), p.A1316-A1316

2007

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The structure of Wza, the translocon for group 1 capsular polysaccharides in Escherichia coli, identifies a new class of outer membrane protein

Nature (London), 2006-11, Vol.444 (7116), p.226-229

2006

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P4-283 Endoproteolysis of presenilin-1 is an intramolecular autocatalytic event

Neurobiology of aging, 2004-07, Vol.25, p.S555-S556

2004

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Characterisation of the expression of a novel constitutive maize promoter in transgenic wheat and maize

Plant cell reports, 2003-02, Vol.21 (6), p.569-576

2003

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Conserved 'PAL'sequence in presenilins is essential for gamma -secretase activity, but not required for formation or stabilization of gamma -secretase complexes

Neurobiology of disease, 2004-04, Vol.15 (3), p.654-666

2004

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Elevation of parietal cell cAMP in cholera toxin transgenic mice results in mucous gland metaplasia

Gastroenterology (New York, N.Y. 1943), 2003-04, Vol.124 (4), p.A101-A101

2003

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Microarray analysis of gastrin-regulated gene expression in parietal cells

Gastroenterology (New York, N.Y. 1943), 2003-04, Vol.124 (4), p.A470-A470

2003

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Amyloid Precursor Protein Secretases
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Presenilin function and γ‐secretase activity

Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and γ‐secretase activity

A domain at the C‐terminus of PS1 is required for presenilinase and γ‐secretase activities

Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Aβ 42/40 ratios

A Presenilin Dimer at the Core of the γ-Secretase Enzyme: Insights from Parallel Analysis of Notch 1 and APP Proteolysis

Conserved “PAL” sequence in presenilins is essential for γ-secretase activity, but not required for formation or stabilization of γ-secretase complexes

Presenilin endoproteolysis is an intramolecular cleavage

Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and [gamma]-secretase activity

Presenilin-1 Protects against Neuronal Apoptosis Caused by Its Interacting Protein PAG

Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein

Gene expression profiling of gastrin target genes in parietal cells

Intestinal Neurogenin 3 directs differentiation of a bipotential secretory progenitor to endocrine cell rather than goblet cell fate

Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic mice

Structure–function relationships of the outer membrane translocon Wza investigated by cryo-electron microscopy and mutagenesis

Enteroendocrine cell expression of a cholecystokinin gene construct in transgenic mice and cultured cells

Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios

Neurogenin 3 overexpression in transgenic mouse intestine promotes endocrine cell development

Transgenic overexpression of Neurogenin 3 in the intestine promotes endocrine cell development to the detriment of goblet cells

The structure of Wza, the translocon for group 1 capsular polysaccharides in Escherichia coli, identifies a new class of outer membrane protein

P4-283 Endoproteolysis of presenilin-1 is an intramolecular autocatalytic event

Characterisation of the expression of a novel constitutive maize promoter in transgenic wheat and maize

Conserved 'PAL'sequence in presenilins is essential for gamma -secretase activity, but not required for formation or stabilization of gamma -secretase complexes

Elevation of parietal cell cAMP in cholera toxin transgenic mice results in mucous gland metaplasia

Microarray analysis of gastrin-regulated gene expression in parietal cells

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