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Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension

The New England journal of medicine, 2023-02, Vol.388 (5), p.395-405

2023

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Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial

The Lancet (British edition), 2015-11, Vol.386 (10008), p.2059-2068

2015

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Aliskiren

Circulation (New York, N.Y.), 2008-08, Vol.118 (7), p.773-784

BROWN, Morris J

2008

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Development of [18F]AldoView as the First Highly Selective Aldosterone Synthase PET Tracer for Imaging of Primary Hyperaldosteronism

Journal of medicinal chemistry, 2021-07, Vol.64 (13), p.9321-9329

2021

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Somatic Mutations Affecting the Selectivity Filter of KCNJ5 Are Frequent in 2 Large Unselected Collections of Adrenal Aldosteronomas

Hypertension (Dallas, Tex. 1979), 2012-03, Vol.59 (3), p.587-591

2012

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Comparison of the Effects of Antihypertensive Agents on Central Blood Pressure and Arterial Stiffness in Isolated Systolic Hypertension

Hypertension (Dallas, Tex. 1979), 2009-08, Vol.54 (2), p.409-413

2009

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Aliskiren and the calcium channel blocker amlodipine combination as an initial treatment strategy for hypertension control (ACCELERATE): a randomised, parallel-group trial

The Lancet (British edition), 2011-01, Vol.377 (9762), p.312-320

2011

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NEFM (Neurofilament Medium) Polypeptide, a Marker for Zona Glomerulosa Cells in Human Adrenal, Inhibits D1R (Dopamine D1 Receptor)-Mediated Secretion of Aldosterone

Hypertension (Dallas, Tex. 1979), 2017-08, Vol.70 (2), p.357-364

2017

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Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial

The lancet. Diabetes & endocrinology, 2016-02, Vol.4 (2), p.136-147

2016

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A comparison of atenolol and nebivolol in isolated systolic hypertension

Journal of hypertension, 2008-02, Vol.26 (2), p.351-356

2008

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Transcriptome Pathway Analysis of Pathological and Physiological Aldosterone-Producing Human Tissues

Hypertension (Dallas, Tex. 1979), 2016-12, Vol.68 (6), p.1424-1431

2016

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Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double‐Blind Randomized Controlled Trial

Journal of the American Heart Association, 2017-11, Vol.6 (11), p.n/a

2017

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Characterization of a novel somatic KCNJ5 mutation delI157 in an aldosterone-producing adenoma

Journal of hypertension, 2012-09, Vol.30 (9), p.1827-1833

2012

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Regulation of aldosterone secretion by Cav1.3

Scientific reports, 2016-04, Vol.6 (1), p.24697-24697, Article 24697

2016

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Increased stroke volume and aortic stiffness contribute to isolated systolic hypertension in young adults

Hypertension (Dallas, Tex. 1979), 2005-07, Vol.46 (1), p.221-226

2005

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Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial

The Lancet (British edition), 2022-10, Vol.400 (10361), p.1417-1425

2022

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Rapid Diagnosis of Primary Aldosteronism: Oxymoron or One Small Step?

Hypertension (Dallas, Tex. 1979), 2017-08, Vol.70 (2), p.247-249

Brown, Morris J

2017

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A common variant of the endothelial nitric oxide synthase (Glu298→Asp) is a major risk factor for coronary artery disease in the UK

Circulation (New York, N.Y.), 1999-10, Vol.100 (14), p.1515-1520

1999

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Baxdrostat for Treatment-Resistant Hypertension. Reply

The New England journal of medicine, 2023-05, Vol.388 (19), p.1821-1822

2023

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Randomized double-blind placebo-controlled study of an angiotensin immunotherapeutic vaccine (PMD3117) in hypertensive subjects

Clinical science (1979), 2004-08, Vol.107 (2), p.167

2004

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Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19

The New England journal of medicine, 2021-09, Vol.385 (12), p.1147-1149

2021

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Therapeutic Potential of Vaccines in the Management of Hypertension

Drugs (New York, N.Y.), 2008-01, Vol.68 (18), p.2557-2560

Brown, Morris J.

2008

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Gating defects of disease-causing de novo mutations in Cav1.3 Ca2+ channels

Channels (Austin, Tex.), 2018-01, Vol.12 (1), p.388-402

2018

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Resistant hypertension: resistance to treatment or resistance to taking treatment?

Heart (British Cardiac Society), 2014-06, Vol.100 (11), p.821-822

Brown, Morris J

2014

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Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension

Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial

Aliskiren

Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension

Development of [18F]AldoView as the First Highly Selective Aldosterone Synthase PET Tracer for Imaging of Primary Hyperaldosteronism

Somatic Mutations Affecting the Selectivity Filter of KCNJ5 Are Frequent in 2 Large Unselected Collections of Adrenal Aldosteronomas

Comparison of the Effects of Antihypertensive Agents on Central Blood Pressure and Arterial Stiffness in Isolated Systolic Hypertension

Aliskiren and the calcium channel blocker amlodipine combination as an initial treatment strategy for hypertension control (ACCELERATE): a randomised, parallel-group trial

NEFM (Neurofilament Medium) Polypeptide, a Marker for Zona Glomerulosa Cells in Human Adrenal, Inhibits D1R (Dopamine D1 Receptor)-Mediated Secretion of Aldosterone

Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial

A comparison of atenolol and nebivolol in isolated systolic hypertension

Transcriptome Pathway Analysis of Pathological and Physiological Aldosterone-Producing Human Tissues

Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double‐Blind Randomized Controlled Trial

Characterization of a novel somatic KCNJ5 mutation delI157 in an aldosterone-producing adenoma

Regulation of aldosterone secretion by Cav1.3

Increased stroke volume and aortic stiffness contribute to isolated systolic hypertension in young adults

Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial

Rapid Diagnosis of Primary Aldosteronism: Oxymoron or One Small Step?

A common variant of the endothelial nitric oxide synthase (Glu298→Asp) is a major risk factor for coronary artery disease in the UK

Baxdrostat for Treatment-Resistant Hypertension. Reply

Randomized double-blind placebo-controlled study of an angiotensin immunotherapeutic vaccine (PMD3117) in hypertensive subjects

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19

Therapeutic Potential of Vaccines in the Management of Hypertension

Gating defects of disease-causing de novo mutations in Cav1.3 Ca2+ channels

Resistant hypertension: resistance to treatment or resistance to taking treatment?

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