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Novel approaches leading towards peptide GPCR de‐orphanisation

British journal of pharmacology, 2020-03, Vol.177 (5), p.961-968

2020

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Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors

Nature communications, 2012-12, Vol.3 (1), p.1329-1329, Article 1329

2012

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Pharmacology and physiological function of the orphan GPRC6A receptor

Basic & clinical pharmacology & toxicology, 2020-06, Vol.126 (S6), p.77-87

2020

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Pharmacology and function of the orphan GPR139 G protein‐coupled receptor

Basic & clinical pharmacology & toxicology, 2020-06, Vol.126 (S6), p.35-46

2020

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Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer

Scientific reports, 2017-04, Vol.7 (1), p.46355-46355, Article 46355

2017

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Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long‐term impairment of the GIP system

Basic & clinical pharmacology & toxicology, 2020-06, Vol.126 (S6), p.122-132

2020

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International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function

Pharmacological reviews, 2020-07, Vol.72 (3), p.558-604

2020

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Structure–activity relationship of GPR15L peptide analogues and investigation of their interaction with the GPR15 receptor

Basic & clinical pharmacology & toxicology, 2023-06, Vol.132 (6), p.459-471

2023

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G protein‐coupled receptor pharmacology—The next generation

Basic & clinical pharmacology & toxicology, 2020-06, Vol.126 (S6), p.3-4

2020

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Molecular Pharmacology of Promiscuous Seven Transmembrane Receptors Sensing Organic Nutrients

Molecular pharmacology, 2009-09, Vol.76 (3), p.453-465

2009

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Structure–Activity Relationship Studies and Optimization of 4‑Hydroxypyridones as GPR84 Agonists

Journal of medicinal chemistry, 2024-03, Vol.67 (5), p.3542-3570

2024

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Delineation of the GPR15 receptor‐mediated Gα protein signalling profile in recombinant mammalian cells

Basic & clinical pharmacology & toxicology, 2022-08, Vol.131 (2), p.104-113

2022

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Detailed In Vitro Pharmacological Characterization of Clinically Tested Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5

Molecular pharmacology, 2020-07, Vol.98 (1), p.49-60

2020

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Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors

European journal of pharmacology, 2015-09, Vol.763 (Pt B), p.233-240

2015

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Real-time trafficking and signaling of the glucagon-like peptide-1 receptor

Molecular and cellular endocrinology, 2014-02, Vol.382 (2), p.938-949

2014

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N-glycosylation and disulfide bonding affects GPRC6A receptor expression, function, and dimerization

FEBS letters, 2015-02, Vol.589 (5), p.588-597

2015

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Positive Allosteric Modulators of Metabotropic Glutamate Receptor 5 as Tool Compounds to Study Signaling Bias

Molecular pharmacology, 2021-05, Vol.99 (5), p.328-341

2021

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Robust GLP‐1 secretion by basic L‐amino acids does not require the GPRC6A receptor

Diabetes, obesity & metabolism, 2017-04, Vol.19 (4), p.599-603

2017

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Strontium is a biased agonist of the calcium-sensing receptor in rat medullary thyroid carcinoma 6-23 cells

The Journal of pharmacology and experimental therapeutics, 2012-12, Vol.343 (3), p.638

2012

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Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors

Current drug targets, 2007-01, Vol.8 (1), p.169

2007

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Interactions between calcium and phosphorus in the regulation of the production of fibroblast growth factor 23 in vivo

American journal of physiology: endocrinology and metabolism, 2013-02, Vol.304 (3), p.E310-E320

2013

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Structure–Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM‐254890, Targeting the Gq Protein

ChemMedChem, 2017-06, Vol.12 (11), p.830-834

2017

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Computer-Aided Discovery of Aromatic l‑α-Amino Acids as Agonists of the Orphan G Protein-Coupled Receptor GPR139

Journal of chemical information and modeling, 2014-06, Vol.54 (6), p.1553-1557

2014

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Oral l-Arginine Stimulates GLP-1 Secretion to Improve Glucose Tolerance in Male Mice

Endocrinology (Philadelphia), 2013-11, Vol.154 (11), p.3978-3983

2013

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Metabolic and skeletal homeostasis are maintained in full locus GPRC6A knockout mice

Scientific reports, 2019-04, Vol.9 (1), p.5995-5995, Article 5995

2019

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Novel approaches leading towards peptide GPCR de‐orphanisation

Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors

Pharmacology and physiological function of the orphan GPRC6A receptor

Pharmacology and function of the orphan GPR139 G protein‐coupled receptor

Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer

Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long‐term impairment of the GIP system

International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function

Structure–activity relationship of GPR15L peptide analogues and investigation of their interaction with the GPR15 receptor

G protein‐coupled receptor pharmacology—The next generation

Molecular Pharmacology of Promiscuous Seven Transmembrane Receptors Sensing Organic Nutrients

Structure–Activity Relationship Studies and Optimization of 4‑Hydroxypyridones as GPR84 Agonists

Delineation of the GPR15 receptor‐mediated Gα protein signalling profile in recombinant mammalian cells

Detailed In Vitro Pharmacological Characterization of Clinically Tested Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5

Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors

Real-time trafficking and signaling of the glucagon-like peptide-1 receptor

N-glycosylation and disulfide bonding affects GPRC6A receptor expression, function, and dimerization

Positive Allosteric Modulators of Metabotropic Glutamate Receptor 5 as Tool Compounds to Study Signaling Bias

Robust GLP‐1 secretion by basic L‐amino acids does not require the GPRC6A receptor

Strontium is a biased agonist of the calcium-sensing receptor in rat medullary thyroid carcinoma 6-23 cells

Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors

Interactions between calcium and phosphorus in the regulation of the production of fibroblast growth factor 23 in vivo

Structure–Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM‐254890, Targeting the Gq Protein

Computer-Aided Discovery of Aromatic l‑α-Amino Acids as Agonists of the Orphan G Protein-Coupled Receptor GPR139

Oral l-Arginine Stimulates GLP-1 Secretion to Improve Glucose Tolerance in Male Mice

Metabolic and skeletal homeostasis are maintained in full locus GPRC6A knockout mice

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