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Therapeutic approaches targeting Apolipoprotein E function in Alzheimer's disease

Molecular neurodegeneration, 2020-01, Vol.15 (1), p.8-8, Article 8

2020

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C9orf72 BAC Mouse Model with Motor Deficits and Neurodegenerative Features of ALS/FTD

Neuron (Cambridge, Mass.), 2016-05, Vol.90 (3), p.521-534

2016

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RAN Translation in Huntington Disease

Neuron (Cambridge, Mass.), 2015-11, Vol.88 (4), p.667-677

2015

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Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain

PloS one, 2013-06, Vol.8 (6), p.e67680-e67680

2013

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Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice

Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (29), p.10732-10737

2014

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Blood-based biomarkers of inflammation in amyotrophic lateral sclerosis

Molecular neurodegeneration, 2022-01, Vol.17 (1), p.11-11, Article 11

2022

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Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function

Neurobiology of aging, 2012-01, Vol.33 (1), p.195.e1-195.e12

2012

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Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways

Acta neuropathologica, 2016-01, Vol.131 (1), p.103-114

2016

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Thinking laterally about neurodegenerative proteinopathies

The Journal of clinical investigation, 2013-05, Vol.123 (5), p.1847-1855

2013

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Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

PloS one, 2020-01, Vol.15 (1), p.e0227655

2020

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Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS

PloS one, 2008-08, Vol.3 (8), p.e2849-e2849

2008

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Subcellular Localization of Matrin 3 Containing Mutations Associated with ALS and Distal Myopathy

PloS one, 2015-11, Vol.10 (11), p.e0142144-e0142144

2015

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Remodeling Alzheimer-amyloidosis models by seeding

Molecular neurodegeneration, 2021-02, Vol.16 (1), p.8-8, Article 8

2021

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A Limited Role for Disulfide Cross-linking in the Aggregation of Mutant SOD1 Linked to Familial Amyotrophic Lateral Sclerosis

The Journal of biological chemistry, 2008-05, Vol.283 (20), p.13528-13537

2008

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Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease

Acta neuropathologica, 2018-12, Vol.136 (6), p.919-938

2018

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Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice

Viruses, 2023-08, Vol.15 (9), p.1819

2023

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Modeling the Competition between Misfolded Aβ Conformers That Produce Distinct Types of Amyloid Pathology in Alzheimer’s Disease

Biomolecules (Basel, Switzerland), 2022-06, Vol.12 (7), p.886

2022

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Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS

Acta neuropathologica, 2016-12, Vol.132 (6), p.827-840

2016

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Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS

Proceedings of the National Academy of Sciences - PNAS, 2009-05, Vol.106 (19), p.7774-7779

2009

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Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease

The Journal of neuroscience, 2005-05, Vol.25 (21), p.5217-5224

2005

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Superoxide dismutase 1 encoding mutations linked to ALS adopts a spectrum of misfolded states

Molecular neurodegeneration, 2011-11, Vol.6 (1), p.77-77

2011

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Copper and Zinc Metallation Status of Copper-Zinc Superoxide Dismutase from Amyotrophic Lateral Sclerosis Transgenic Mice

The Journal of biological chemistry, 2011-01, Vol.286 (4), p.2795-2806

2011

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Astrocytic apoE4 and tau: Deadly combination for neurons

Cell reports. Medicine, 2021-06, Vol.2 (6), p.100316-100316, Article 100316

2021

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Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau

Acta neuropathologica communications, 2023-10, Vol.11 (1), p.172-172, Article 172

2023

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Cytosolic proteins lose solubility as amyloid deposits in a transgenic mouse model of Alzheimer-type amyloidosis

Human molecular genetics, 2013-07, Vol.22 (14), p.2765-2774

2013

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Therapeutic approaches targeting Apolipoprotein E function in Alzheimer's disease

C9orf72 BAC Mouse Model with Motor Deficits and Neurodegenerative Features of ALS/FTD

RAN Translation in Huntington Disease

Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain

Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice

Blood-based biomarkers of inflammation in amyotrophic lateral sclerosis

Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function

Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways

Thinking laterally about neurodegenerative proteinopathies

Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS

Subcellular Localization of Matrin 3 Containing Mutations Associated with ALS and Distal Myopathy

Remodeling Alzheimer-amyloidosis models by seeding

A Limited Role for Disulfide Cross-linking in the Aggregation of Mutant SOD1 Linked to Familial Amyotrophic Lateral Sclerosis

Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease

Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice

Modeling the Competition between Misfolded Aβ Conformers That Produce Distinct Types of Amyloid Pathology in Alzheimer’s Disease

Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS

Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS

Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease

Superoxide dismutase 1 encoding mutations linked to ALS adopts a spectrum of misfolded states

Copper and Zinc Metallation Status of Copper-Zinc Superoxide Dismutase from Amyotrophic Lateral Sclerosis Transgenic Mice

Astrocytic apoE4 and tau: Deadly combination for neurons

Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau

Cytosolic proteins lose solubility as amyloid deposits in a transgenic mouse model of Alzheimer-type amyloidosis

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