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RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT

Circulation research, 2021-02, Vol.128 (3), p.321-331

2021

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Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic

Proceedings of the National Academy of Sciences - PNAS, 2019-03, Vol.116 (11), p.4810-4815

2019

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Cardiac Calcium ATPase Dimerization Measured by Cross-Linking and Fluorescence Energy Transfer

Biophysical journal, 2016-09, Vol.111 (6), p.1192-1202

2016

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Phosphorylated Phospholamban Stabilizes a Compact Conformation of the Cardiac Calcium-ATPase

Biophysical journal, 2013-10, Vol.105 (8), p.1812-1821

2013

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The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function

Cell calcium (Edinburgh), 2019-09, Vol.82 (9), p.102063-102063, Article 102063

2019

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Assessment of dynamic cardiac repolarization and contractility in patients with hypertrophic cardiomyopathy

PloS one, 2021-02, Vol.16 (2), p.e0246768-e0246768

2021

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Structure–Activity Relationships for the N‑Me- Versus N‑H-Amide Modification to Macrocyclic ent-Verticilide Antiarrhythmics

ACS medicinal chemistry letters, 2022-11, Vol.13 (11), p.1755-1762

2022

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2-Color calcium pump reveals closure of the cytoplasmic headpiece with calcium binding

PloS one, 2012-07, Vol.7 (7), p.e40369-e40369

2012

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Animal Models to Study Cardiac Arrhythmias

Circulation research, 2022-06, Vol.130 (12), p.1926-1964

2022

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The Purkinje-myocardial junction is the anatomic origin of ventricular arrhythmia in CPVT

JCI insight, 2022-02, Vol.7 (3)

2022

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Thyroid and Glucocorticoid Hormones Promote Functional T-Tubule Development in Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes

Circulation research, 2017-12, Vol.121 (12), p.1323-1330

2017

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SPEG Kinase: Hitting the Brake in Atrial Fibrillation

Circulation (New York, N.Y.), 2020-09, Vol.142 (12), p.1173-1175

2020

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Exercise Causes Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in Plakophilin-2-Deficient Hearts

Circulation (New York, N.Y.), 2022-05, Vol.145 (19), p.1480-1496

2022

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The selective RyR2 inhibitor ent-verticilide suppresses atrial fibrillation susceptibility caused by Pitx2 deficiency

Journal of molecular and cellular cardiology, 2023-07, Vol.180, p.1-9

2023

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RyR2 inhibition with dantrolene is antiarrhythmic, prevents further pathological remodeling, and improves cardiac function in chronic ischemic heart disease

Journal of molecular and cellular cardiology, 2023-08, Vol.181, p.67-78

2023

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Impaired Dynamic Sarcoplasmic Reticulum Ca Buffering in Autosomal Dominant CPVT2

Circulation research, 2022-09, Vol.131 (8), p.673-686

2022

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A High-Throughput Screening Assay to Identify Drugs that Can Treat Long QT Syndrome Caused by Trafficking-Deficient K V 11.1 (hERG) Variants

Molecular pharmacology, 2022-04, Vol.101 (4), p.236-245

2022

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A High-Throughput Screening Assay to Identify Drugs that Can Treat Long QT Syndrome Caused by Trafficking-Deficient KV11.1 (hERG) Variants

Molecular pharmacology, 2022-04, Vol.101 (4), p.236-245

2022

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In Vivo Pharmacokinetic and Pharmacodynamic Properties of the Antiarrhythmic Molecule ent -Verticilide

The Journal of pharmacology and experimental therapeutics, 2023-06, Vol.385 (3), p.205

2023

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Intrinsically disordered HAX-1 regulates Ca2+ cycling by interacting with lipid membranes and the phospholamban cytoplasmic region

Biochimica et biophysica acta. Biomembranes, 2020-01, Vol.1862 (1), p.183034-183034, Article 183034

2020

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Patient-independent human induced pluripotent stem cell model: A new tool for rapid determination of genetic variant pathogenicity in long QT syndrome

Heart rhythm, 2019-11, Vol.16 (11), p.1686-1695

2019

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ent -Verticilide B1 Inhibits Type 2 Ryanodine Receptor Channels and is Antiarrhythmic in Casq2 -/- Mice

Molecular pharmacology, 2024-02, Vol.105 (3), p.194

2024

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Eicosanoid-Regulated Myeloid ENaC and Isolevuglandin Formation in Human Salt-Sensitive Hypertension

Hypertension (Dallas, Tex. 1979), 2024-03, Vol.81 (3), p.516

2024

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Ring Size as an Independent Variable in Cyclooligomeric Depsipeptide Antiarrhythmic Activity

ACS medicinal chemistry letters, 2021-12, Vol.12 (12), p.1942-1947

2021

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RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT

Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic

Cardiac Calcium ATPase Dimerization Measured by Cross-Linking and Fluorescence Energy Transfer

Phosphorylated Phospholamban Stabilizes a Compact Conformation of the Cardiac Calcium-ATPase

The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function

Assessment of dynamic cardiac repolarization and contractility in patients with hypertrophic cardiomyopathy

Structure–Activity Relationships for the N‑Me- Versus N‑H-Amide Modification to Macrocyclic ent-Verticilide Antiarrhythmics

2-Color calcium pump reveals closure of the cytoplasmic headpiece with calcium binding

Animal Models to Study Cardiac Arrhythmias

The Purkinje-myocardial junction is the anatomic origin of ventricular arrhythmia in CPVT

Thyroid and Glucocorticoid Hormones Promote Functional T-Tubule Development in Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes

SPEG Kinase: Hitting the Brake in Atrial Fibrillation

Exercise Causes Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in Plakophilin-2-Deficient Hearts

The selective RyR2 inhibitor ent-verticilide suppresses atrial fibrillation susceptibility caused by Pitx2 deficiency

RyR2 inhibition with dantrolene is antiarrhythmic, prevents further pathological remodeling, and improves cardiac function in chronic ischemic heart disease

Impaired Dynamic Sarcoplasmic Reticulum Ca Buffering in Autosomal Dominant CPVT2

A High-Throughput Screening Assay to Identify Drugs that Can Treat Long QT Syndrome Caused by Trafficking-Deficient K V 11.1 (hERG) Variants

A High-Throughput Screening Assay to Identify Drugs that Can Treat Long QT Syndrome Caused by Trafficking-Deficient KV11.1 (hERG) Variants

In Vivo Pharmacokinetic and Pharmacodynamic Properties of the Antiarrhythmic Molecule ent -Verticilide

Intrinsically disordered HAX-1 regulates Ca2+ cycling by interacting with lipid membranes and the phospholamban cytoplasmic region

Patient-independent human induced pluripotent stem cell model: A new tool for rapid determination of genetic variant pathogenicity in long QT syndrome

ent -Verticilide B1 Inhibits Type 2 Ryanodine Receptor Channels and is Antiarrhythmic in Casq2 -/- Mice

Eicosanoid-Regulated Myeloid ENaC and Isolevuglandin Formation in Human Salt-Sensitive Hypertension

LNK/SH2B3 loss of function increases susceptibility to murine and human atrial fibrillation

Ring Size as an Independent Variable in Cyclooligomeric Depsipeptide Antiarrhythmic Activity

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