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Enzymatic Neutralization of the Chemical Warfare Agent VX: Evolution of Phosphotriesterase for Phosphorothiolate Hydrolysis

Journal of the American Chemical Society, 2013-07, Vol.135 (28), p.10426-10432

2013

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Stereoselective Formation of Multiple Reaction Products by the Phosphotriesterase from Sphingobium sp. TCM1

Biochemistry (Easton), 2020-03, Vol.59 (12), p.1273-1288

2020

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Transition State Analysis of the Reaction Catalyzed by the Phosphotriesterase from Sphingobium sp. TCM1

Biochemistry (Easton), 2019-03, Vol.58 (9), p.1246-1259

2019

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Chemical Mechanism of the Phosphotriesterase from Sphingobium sp. Strain TCM1, an Enzyme Capable of Hydrolyzing Organophosphate Flame Retardants

Journal of the American Chemical Society, 2016-03, Vol.138 (9), p.2921-2924

2016

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Catalytic mechanisms for phosphotriesterases

Biochimica et biophysica acta, 2013-01, Vol.1834 (1), p.443-453

2013

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The evolution of phosphotriesterase for decontamination and detoxification of organophosphorus chemical warfare agents

Chemico-biological interactions, 2019-08, Vol.308, p.80-88

2019

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A Chemoenzymatic Synthesis of the (R P)‑Isomer of the Antiviral Prodrug Remdesivir

Biochemistry (Easton), 2020-08, Vol.59 (33), p.3038-3043

2020

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Substrate Analogues for the Enzyme-Catalyzed Detoxification of the Organophosphate Nerve AgentsSarin, Soman, and Cyclosarin

Biochemistry (Easton), 2021-09, Vol.60 (38), p.2875-2887

2021

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Enzyme-Catalyzed Kinetic Resolution of Chiral Precursors to Antiviral Prodrugs

Biochemistry (Easton), 2019-07, Vol.58 (29), p.3204-3211

2019

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Variants of Phosphotriesterase for the Enhanced Detoxification of the Chemical Warfare Agent VR

Biochemistry (Easton), 2015-09, Vol.54 (35), p.5502-5512

2015

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Overcoming the Challenges of Enzyme Evolution To Adapt Phosphotriesterase for V‑Agent Decontamination

Biochemistry (Easton), 2019-04, Vol.58 (15), p.2039-2053

2019

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Enzymes for the Homeland Defense: Optimizing Phosphotriesterase for the Hydrolysis of Organophosphate Nerve Agents

Biochemistry (Easton), 2012-08, Vol.51 (32), p.6463-6475

2012

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Multiple Reaction Products from the Hydrolysis of Chiral and Prochiral Organophosphate Substrates by the Phosphotriesterase from Sphingobium sp. TCM1

Biochemistry (Easton), 2018-03, Vol.57 (12), p.1842-1846

2018

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Interrogation of the Substrate Profile and Catalytic Properties of the Phosphotriesterase from Sphingobium sp. Strain TCM1: An Enzyme Capable of Hydrolyzing Organophosphate Flame Retardants and Plasticizers

Biochemistry (Easton), 2015-12, Vol.54 (51), p.7539-7549

2015

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Nanoscavenger provides long-term prophylactic protection against nerve agents in rodents

Science translational medicine, 2019-01, Vol.11 (473)

2019

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Structure of a Novel Phosphotriesterase from Sphingobium sp. TCM1: A Familiar Binuclear Metal Center Embedded in a Seven-Bladed β‑Propeller Protein Fold

Biochemistry (Easton), 2016-07, Vol.55 (28), p.3963-3974

2016

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An OPAA enzyme mutant with increased catalytic efficiency on the nerve agents sarin, soman, and GP

Enzyme and microbial technology, 2018-05, Vol.112, p.65-71

2018

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Correction to Structure of a Novel Phosphotriesterase from Sphingobium sp. TCM1: A Familiar Binuclear Metal Center Embedded in a Seven-Bladed β‑Propeller Protein Fold

Biochemistry (Easton), 2016-08, Vol.55 (34), p.4871-4871

2016

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The N-Terminus of Glycogen Phosphorylase b Is Not Required for Activation by Adenosine 5′-Monophosphate

Biochemistry (Easton), 2010-06, Vol.49 (23), p.4760-4765

2010

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A Chemo-Enzymatic Synthesis of the (RP)-Isomer of the Antiviral Prodrug Remdesivir

Biochemistry (Easton), 2020-08, Vol.59 (33), p.3038-3043

2020

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Multiple Reaction Products from the Hydrolysis of Chiral and Pro-chiral Organophosphate Substrates by the Phosphotri-esterase from Sphingobium sp. TCM1

Biochemistry (Easton), 2018-03, Vol.57 (12), p.1842-1846

2018

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The N-terminus of Glycogen Phosphorylase b is Not Required for Activation by AMP

Biochemistry (Easton), 2010-06, Vol.49 (23), p.4760-4765

2010

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Zinc Amidohydrolase Superfamily

Encyclopedia of Metalloproteins, p.2354-2359

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Biallelic mutations in IRF8 impair human NK cell maturation and function

The Journal of clinical investigation, 2017-01, Vol.127 (1), p.306-320

2017

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Enzymatic Neutralization of the Chemical Warfare Agent VX: Evolution of Phosphotriesterase for Phosphorothiolate Hydrolysis

Stereoselective Formation of Multiple Reaction Products by the Phosphotriesterase from Sphingobium sp. TCM1

Transition State Analysis of the Reaction Catalyzed by the Phosphotriesterase from Sphingobium sp. TCM1

Chemical Mechanism of the Phosphotriesterase from Sphingobium sp. Strain TCM1, an Enzyme Capable of Hydrolyzing Organophosphate Flame Retardants

Catalytic mechanisms for phosphotriesterases

The evolution of phosphotriesterase for decontamination and detoxification of organophosphorus chemical warfare agents

A Chemoenzymatic Synthesis of the (R P)‑Isomer of the Antiviral Prodrug Remdesivir

Substrate Analogues for the Enzyme-Catalyzed Detoxification of the Organophosphate Nerve AgentsSarin, Soman, and Cyclosarin

Enzyme-Catalyzed Kinetic Resolution of Chiral Precursors to Antiviral Prodrugs

Variants of Phosphotriesterase for the Enhanced Detoxification of the Chemical Warfare Agent VR

Overcoming the Challenges of Enzyme Evolution To Adapt Phosphotriesterase for V‑Agent Decontamination

Enzymes for the Homeland Defense: Optimizing Phosphotriesterase for the Hydrolysis of Organophosphate Nerve Agents

Multiple Reaction Products from the Hydrolysis of Chiral and Prochiral Organophosphate Substrates by the Phosphotriesterase from Sphingobium sp. TCM1

Interrogation of the Substrate Profile and Catalytic Properties of the Phosphotriesterase from Sphingobium sp. Strain TCM1: An Enzyme Capable of Hydrolyzing Organophosphate Flame Retardants and Plasticizers

Nanoscavenger provides long-term prophylactic protection against nerve agents in rodents

Structure of a Novel Phosphotriesterase from Sphingobium sp. TCM1: A Familiar Binuclear Metal Center Embedded in a Seven-Bladed β‑Propeller Protein Fold

An OPAA enzyme mutant with increased catalytic efficiency on the nerve agents sarin, soman, and GP

Correction to Structure of a Novel Phosphotriesterase from Sphingobium sp. TCM1: A Familiar Binuclear Metal Center Embedded in a Seven-Bladed β‑Propeller Protein Fold

The N-Terminus of Glycogen Phosphorylase b Is Not Required for Activation by Adenosine 5′-Monophosphate

A Chemo-Enzymatic Synthesis of the (RP)-Isomer of the Antiviral Prodrug Remdesivir

Multiple Reaction Products from the Hydrolysis of Chiral and Pro-chiral Organophosphate Substrates by the Phosphotri-esterase from Sphingobium sp. TCM1

The N-terminus of Glycogen Phosphorylase b is Not Required for Activation by AMP

Zinc Amidohydrolase Superfamily

Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency

Biallelic mutations in IRF8 impair human NK cell maturation and function

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