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Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders

Molecular and cellular neuroscience, 2004-01, Vol.25 (1), p.42-55

2004

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L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity

Biochemistry (Easton), 2000-08, Vol.39 (30), p.8698-8704

2000

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Gamma-secretase as a therapeutic target for the treatment of Alzheimer's disease

Current pharmaceutical design, 2005-01, Vol.11 (26), p.3363-3382

2005

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Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-β(42) peptide in vascular dementia

Neuropathology and applied neurobiology, 2006-04, Vol.32 (2), p.103-118

2006

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Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and γ‐secretase activity

Journal of neurochemistry, 2005-09, Vol.94 (5), p.1315-1328

2005

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Determination of guinea-pig cortical γ-secretase activity ex vivo following the systemic administration of a γ-secretase inhibitor

Neuropharmacology, 2005-06, Vol.48 (7), p.1002-1011

2005

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Gamma-secretase inhibition

Biochemical Society transactions, 2002-08, Vol.30 (4), p.534-537

2002

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Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism

The Journal of biological chemistry, 2004-10, Vol.279 (42), p.43419-43426

2004

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Proteolytic Fragments of Alzheimer’s Disease‐Associated Presenilin 1 Are Present in Synaptic Organelles and Growth Cone Membranes of Rat Brain

Journal of neurochemistry, 1999-04, Vol.72 (4), p.1564-1573

1999

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Homodimerization of Amyloid Precursor Protein and Its Implication in the Amyloidogenic Pathway of Alzheimer's Disease

The Journal of biological chemistry, 2001-09, Vol.276 (36), p.33923-33929

2001

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C‐terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation

Journal of neurochemistry, 2006-01, Vol.96 (1), p.218-227

2006

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Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease

Expert opinion on investigational drugs, 2005-11, Vol.14 (11), p.1385-1409

2005

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The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I)

Science (American Association for the Advancement of Science), 1996-03, Vol.271 (5254), p.1406-1409

1996

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γ-Secretase Complex Assembly within the Early Secretory Pathway

The Journal of biological chemistry, 2005-02, Vol.280 (8), p.6471-6478

2005

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4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2006-01, Vol.16 (2), p.280-284

2006

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Generation of C‐terminally truncated amyloid‐β peptides is dependent on γ‐secretase activity

Journal of neurochemistry, 2002-08, Vol.82 (3), p.563-575

2002

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Cyclic sulfamide γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2005-10, Vol.15 (19), p.4212-4216

2005

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Reactive oxygen species and Alzheimer's disease

Biochemical pharmacology, 1997-09, Vol.54 (5), p.533-539

1997

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Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

The Journal of biological chemistry, 2001-11, Vol.276 (48), p.45394-45402

2001

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Design and Synthesis of Highly Potent Benzodiazepine γ-Secretase Inhibitors: Preparation of (2S,3R)-3-(3,4- Difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]- diazepin-3-yl)butyramide by Use of an Asymmetric Ireland−Claisen Rearrangement

Journal of medicinal chemistry, 2003-06, Vol.46 (12), p.2275-2278

2003

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In Vitro Characterization of the Presenilin-Dependent γ-Secretase Complex Using a Novel Affinity Ligand

Biochemistry (Easton), 2003-07, Vol.42 (27), p.8133-8142

2003

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The Intramembrane Cleavage Site of the Amyloid Precursor Protein Depends on the Length of Its Transmembrane Domain

Proceedings of the National Academy of Sciences - PNAS, 2002-02, Vol.99 (3), p.1365-1370

2002

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The βA4 amyloid precursor protein binding to copper

FEBS letters, 1994-07, Vol.349 (1), p.109-116

1994

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Regulation of Amyloid Protein Precursor (APP) Binding to Collagen and Mapping of the Binding Sites on APP and Collagen Type I (∗)

The Journal of biological chemistry, 1996-01, Vol.271 (3), p.1613-1620

1996

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Fatty acids increase presenilin-1 levels and γ-secretase activity in PSwt-1 cells

Journal of lipid research, 2004-12, Vol.45 (12), p.2368-2376

2004

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Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders

L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity

Gamma-secretase as a therapeutic target for the treatment of Alzheimer's disease

Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-β(42) peptide in vascular dementia

Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and γ‐secretase activity

Determination of guinea-pig cortical γ-secretase activity ex vivo following the systemic administration of a γ-secretase inhibitor

Gamma-secretase inhibition

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism

Proteolytic Fragments of Alzheimer’s Disease‐Associated Presenilin 1 Are Present in Synaptic Organelles and Growth Cone Membranes of Rat Brain

Homodimerization of Amyloid Precursor Protein and Its Implication in the Amyloidogenic Pathway of Alzheimer's Disease

C‐terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation

Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease

The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I)

γ-Secretase Complex Assembly within the Early Secretory Pathway

4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors

Generation of C‐terminally truncated amyloid‐β peptides is dependent on γ‐secretase activity

Cyclic sulfamide γ-secretase inhibitors

Reactive oxygen species and Alzheimer's disease

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

Design and Synthesis of Highly Potent Benzodiazepine γ-Secretase Inhibitors: Preparation of (2S,3R)-3-(3,4- Difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]- diazepin-3-yl)butyramide by Use of an Asymmetric Ireland−Claisen Rearrangement

In Vitro Characterization of the Presenilin-Dependent γ-Secretase Complex Using a Novel Affinity Ligand

The Intramembrane Cleavage Site of the Amyloid Precursor Protein Depends on the Length of Its Transmembrane Domain

The βA4 amyloid precursor protein binding to copper

Regulation of Amyloid Protein Precursor (APP) Binding to Collagen and Mapping of the Binding Sites on APP and Collagen Type I (∗)

Fatty acids increase presenilin-1 levels and γ-secretase activity in PSwt-1 cells

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