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The clinical progress of mRNA vaccines and immunotherapies

Nature biotechnology, 2022-06, Vol.40 (6), p.840-854

2022

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Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency

The New England journal of medicine, 2019-09, Vol.381 (10), p.933-944

2019

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Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Encenicline, a Selective α7 Nicotinic Receptor Partial Agonist, in Single Ascending-dose and Bioavailability Studies

Clinical therapeutics, 2015-02, Vol.37 (2), p.311-324

2015

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A phase I/II study of intrathecal idursulfase-IT in children with severe mucopolysaccharidosis II

Genetics in medicine, 2016-01, Vol.18 (1), p.73-81

2016

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A New Class of Diamine-Based Human Histamine H3 Receptor Antagonists: 4-(Aminoalkoxy)benzylamines

Journal of medicinal chemistry, 2003-08, Vol.46 (18), p.3938-3944

2003

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Levels of glycosaminoglycans in the cerebrospinal fluid of healthy young adults, surrogate-normal children, and Hunter syndrome patients with and without cognitive impairment

Molecular genetics and metabolism reports, 2015-12, Vol.5 (C), p.103-106

2015

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Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling

Bioorganic & medicinal chemistry, 2008-03, Vol.16 (6), p.2968-2973

2008

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Pharmacological characterization of JNJ-28583867, a histamine H3 receptor antagonist and serotonin reuptake inhibitor

European journal of pharmacology, 2007-12, Vol.576 (1-3), p.43-54

2007

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A phase 1/2 study of intrathecal heparan-N-sulfatase in patients with mucopolysaccharidosis IIIA

Molecular genetics and metabolism, 2016-07, Vol.118 (3), p.198-205

2016

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Dual serotonin transporter/histamine H3 ligands : Optimization of the H3 pharmacophore

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (3), p.702-706

2007

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Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms

British journal of pharmacology, 2006-05, Vol.148 (1), p.102-113

2006

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Aplysamine-1 and related analogs as histamine H3 receptor antagonists

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (4), p.897-900

2006

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Phase 1 Single‐ and Multiple‐Ascending‐Dose Randomized Studies of the Safety, Pharmacokinetics, and Pharmacodynamics of AG‐348, a First‐in‐Class Allosteric Activator of Pyruvate Kinase R, in Healthy Volunteers

Clinical pharmacology in drug development, 2019-02, Vol.8 (2), p.246-259

2019

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Neurocognitive clinical outcome assessments for inborn errors of metabolism and other rare conditions

Molecular genetics and metabolism, 2016-06, Vol.118 (2), p.65-69

2016

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Immunogenicity of idursulfase and clinical outcomes in very young patients (16 months to 7.5 years) with mucopolysaccharidosis II (Hunter syndrome)

Orphanet journal of rare diseases, 2015-04, Vol.10 (1), p.50, Article 50

2015

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Radiosynthesis and biodistribution of a histamine H3 receptor antagonist 4-[3-(4-piperidin-1-yl-but-1-ynyl)-[11C]benzyl]-morpholine: evaluation of a potential PET ligand

Nuclear medicine and biology, 2006-08, Vol.33 (6), p.801-810

2006

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A novel LC-MS/MS assay for heparan sulfate screening in the cerebrospinal fluid of mucopolysaccharidosis IIIA patients

Bioanalysis, 2016-02, Vol.8 (4), p.285

2016

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Behavioral Characterization of Mice Lacking Histamine H3 Receptors

Molecular pharmacology, 2002-08, Vol.62 (2), p.389

2002

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Characterization of Soluble Forms of Nonchimeric Type V Adenylyl Cyclases

Proceedings of the National Academy of Sciences - PNAS, 1997-04, Vol.94 (7), p.2915-2920

1997

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Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors

Bioorganic & medicinal chemistry letters, , Vol.17 (9), p.2603-2607

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Patient Voice in Rare Disease Drug Development and Endpoints

Therapeutic innovation & regulatory science, 2017-03, Vol.51 (2), p.257-263

2017

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In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor

European journal of pharmacology, 2008-06, Vol.587 (1), p.141-146

2008

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4-Phenoxypiperidines: Potent, Conformationally Restricted, Non-Imidazole Histamine H3 Antagonists

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.2229-2238

2005

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Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists

European journal of medicinal chemistry, 2009-11, Vol.44 (11), p.4413-4425

2009

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Novel Benzamide-Based Histamine H3 Receptor Antagonists: The Identification of Two Candidates for Clinical Development

ACS medicinal chemistry letters, 2015-04, Vol.6 (4), p.450-454

2015

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The clinical progress of mRNA vaccines and immunotherapies

Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency

Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Encenicline, a Selective α7 Nicotinic Receptor Partial Agonist, in Single Ascending-dose and Bioavailability Studies

A phase I/II study of intrathecal idursulfase-IT in children with severe mucopolysaccharidosis II

A New Class of Diamine-Based Human Histamine H3 Receptor Antagonists: 4-(Aminoalkoxy)benzylamines

Levels of glycosaminoglycans in the cerebrospinal fluid of healthy young adults, surrogate-normal children, and Hunter syndrome patients with and without cognitive impairment

Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling

Pharmacological characterization of JNJ-28583867, a histamine H3 receptor antagonist and serotonin reuptake inhibitor

A phase 1/2 study of intrathecal heparan-N-sulfatase in patients with mucopolysaccharidosis IIIA

Dual serotonin transporter/histamine H3 ligands : Optimization of the H3 pharmacophore

Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms

Aplysamine-1 and related analogs as histamine H3 receptor antagonists

Phase 1 Single‐ and Multiple‐Ascending‐Dose Randomized Studies of the Safety, Pharmacokinetics, and Pharmacodynamics of AG‐348, a First‐in‐Class Allosteric Activator of Pyruvate Kinase R, in Healthy Volunteers

Neurocognitive clinical outcome assessments for inborn errors of metabolism and other rare conditions

Immunogenicity of idursulfase and clinical outcomes in very young patients (16 months to 7.5 years) with mucopolysaccharidosis II (Hunter syndrome)

Radiosynthesis and biodistribution of a histamine H3 receptor antagonist 4-[3-(4-piperidin-1-yl-but-1-ynyl)-[11C]benzyl]-morpholine: evaluation of a potential PET ligand

A novel LC-MS/MS assay for heparan sulfate screening in the cerebrospinal fluid of mucopolysaccharidosis IIIA patients

Behavioral Characterization of Mice Lacking Histamine H3 Receptors

Characterization of Soluble Forms of Nonchimeric Type V Adenylyl Cyclases

Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors

Patient Voice in Rare Disease Drug Development and Endpoints

In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor

4-Phenoxypiperidines: Potent, Conformationally Restricted, Non-Imidazole Histamine H3 Antagonists

Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists

Novel Benzamide-Based Histamine H3 Receptor Antagonists: The Identification of Two Candidates for Clinical Development

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