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A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening

International journal of pharmaceutics, 2011-04, Vol.408 (1-2), p.67-75

2011

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A limited sampling strategy based on maximum a posteriori Bayesian estimation for a five-probe phenotyping cocktail

European journal of clinical pharmacology, 2016, Vol.72 (1), p.39-51

2016

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Dodecyl creatine ester improves cognitive function and identifies key protein drivers including KIF1A and PLCB1 in a mouse model of creatine transporter deficiency

Frontiers in molecular neuroscience, 2023-03, Vol.16, p.1118707-1118707

2023

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Population Pharmacokinetic Model of Plasma and Cellular Mycophenolic Acid in Kidney Transplant Patients from the CIMTRE Study

Drugs in R&D, 2020-12, Vol.20 (4), p.331-342

2020

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Effect of a short-term HAART on SIV load in macaque tissues is dependent on time of initiation and antiviral diffusion

Retrovirology, 2010-09, Vol.7 (1), p.78-78, Article 78

2010

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Design optimisation for pharmacokinetic modeling of a cocktail of phenotyping drugs

Pharmaceutical statistics : the journal of the pharmaceutical industry, 2016-03, Vol.15 (2), p.165-177

2016

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Can a cocktail designed for phenotyping pharmacokinetics and metabolism enzymes in human be used efficiently in rat?

Xenobiotica, 2012-04, Vol.42 (4), p.349-354

2012

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Evidence and Possible Consequences of the Phosphorylation of Nucleoside Reverse Transcriptase Inhibitors in Human Red Blood Cells

Antimicrobial Agents and Chemotherapy, 2007-06, Vol.51 (6), p.2105-2111

2007

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Specificity enhancement with LC-positive ESI-MS/MS for the measurement of nucleotides: application to the quantitative determination of carbovir triphosphate, lamivudine triphosphate and tenofovir diphosphate in human peripheral blood mononuclear cells

Journal of mass spectrometry., 2008-02, Vol.43 (2), p.224-233

2008

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Biochemical and analytical development of the CIME cocktail for drug fate assessment in humans

Rapid communications in mass spectrometry, 2010-08, Vol.24 (16), p.2407-2419

2010

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Measurement of Intracellular Didanosine and Tenofovir Phosphorylated Metabolites and Possible Interaction of the Two Drugs in Human Immunodeficiency Virus-Infected Patients

Antimicrobial Agents and Chemotherapy, 2005-05, Vol.49 (5), p.1907-1914

2005

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Liquid chromatography–tandem mass spectrometry assays for intracellular deoxyribonucleotide triphosphate competitors of nucleoside antiretrovirals

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003-06, Vol.789 (2), p.273-281

2003

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Improved method to quantify intracellular zidovudine mono- and triphosphate in peripheral blood mononuclear cells by liquid chromatography-tandem mass spectrometry

Journal of mass spectrometry., 2007-03, Vol.42 (3), p.389-404

2007

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ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages

Antiviral therapy, 2004-08, Vol.9 (4), p.519-528

2004

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Human Immunodeficiency Virus Type 1: Resistance to Nucleoside Analogues and Replicative Capacity in Primary Human Macrophages

Journal of Virology, 2007-05, Vol.81 (9), p.4540-4550

2007

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Improved method for the simultaneous determination of d4T, 3TC and ddl intracellular phosphorylated anabolites in human peripheral-blood mononuclear cells using high-performance liquid chromatography/tandem mass spectrometry

Rapid communications in mass spectrometry, 2002-01, Vol.16 (6), p.555-565

2002

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Development of an assay method for the detection and quantification of protease and non-nucleoside reverse transcriptase inhibitors in plasma and in peripherical blood mononuclear cells by liquid chromatography coupled with ultraviolet or tandem mass spectrometry detection

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-05, Vol.819 (1), p.47-57

2005

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Significant levels of intracellular stavudine triphosphate are found in HIV-infected zidovudine-treated patients

AIDS (London), 2003-03, Vol.17 (4), p.555-561

2003

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In Vitro Primary Human and Animal Cell-Based Blood−Brain Barrier Models as a Screening Tool in Drug Discovery

Molecular pharmaceutics, 2011-06, Vol.8 (3), p.651-663

2011

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Predicting plutonium decorporation efficacy after intravenous administration of DTPA formulations : Study of pharmacokinetic-pharmacodynamic relationships in rats

Pharmaceutical research, 2006-09, Vol.23 (9), p.2030-2035

2006

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Sensitive and specific LC–ESI–MS/MS method for the determination of a styrylquinoline, BA011FZ041, a potent HIV anti-integrase agent, in rat plasma

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007-05, Vol.850 (1), p.259-266

2007

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Effect of Cell Cycle Arrest on the Activity of Nucleoside Analogues against Human Immunodeficiency Virus Type 1

Journal of Virology, 2005-12, Vol.79 (23), p.14815-14821

2005

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Evaluation of a six-probe cocktail (caffeine, tolbutamide, omeprazole, dextromethorphan, midazolam, and digoxin) approach to estimate hepatic drug detoxification capability and dosage requirements after a single oral dosing in healthy Chinese volunteers

Naunyn-Schmiedeberg's archives of pharmacology, 2022-07, Vol.395 (7), p.815-826

2022

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Direct determination of phosphorylated intracellular anabolites of stavudine (d4T) by liquid chromatography/tandem mass spectrometry

Rapid communications in mass spectrometry, 2001-01, Vol.15 (16), p.1401-1408

2001

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Quantification of the Effects on Viral DNA Synthesis of Reverse Transcriptase Mutations Conferring Human Immunodeficiency Virus Type 1 Resistance to Nucleoside Analogues

Journal of Virology, 2005-01, Vol.79 (2), p.812-822

2005

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A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening

A limited sampling strategy based on maximum a posteriori Bayesian estimation for a five-probe phenotyping cocktail

Dodecyl creatine ester improves cognitive function and identifies key protein drivers including KIF1A and PLCB1 in a mouse model of creatine transporter deficiency

Population Pharmacokinetic Model of Plasma and Cellular Mycophenolic Acid in Kidney Transplant Patients from the CIMTRE Study

Effect of a short-term HAART on SIV load in macaque tissues is dependent on time of initiation and antiviral diffusion

Design optimisation for pharmacokinetic modeling of a cocktail of phenotyping drugs

Can a cocktail designed for phenotyping pharmacokinetics and metabolism enzymes in human be used efficiently in rat?

Evidence and Possible Consequences of the Phosphorylation of Nucleoside Reverse Transcriptase Inhibitors in Human Red Blood Cells

Specificity enhancement with LC-positive ESI-MS/MS for the measurement of nucleotides: application to the quantitative determination of carbovir triphosphate, lamivudine triphosphate and tenofovir diphosphate in human peripheral blood mononuclear cells

Biochemical and analytical development of the CIME cocktail for drug fate assessment in humans

Measurement of Intracellular Didanosine and Tenofovir Phosphorylated Metabolites and Possible Interaction of the Two Drugs in Human Immunodeficiency Virus-Infected Patients

Liquid chromatography–tandem mass spectrometry assays for intracellular deoxyribonucleotide triphosphate competitors of nucleoside antiretrovirals

Improved method to quantify intracellular zidovudine mono- and triphosphate in peripheral blood mononuclear cells by liquid chromatography-tandem mass spectrometry

ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages

Human Immunodeficiency Virus Type 1: Resistance to Nucleoside Analogues and Replicative Capacity in Primary Human Macrophages

Improved method for the simultaneous determination of d4T, 3TC and ddl intracellular phosphorylated anabolites in human peripheral-blood mononuclear cells using high-performance liquid chromatography/tandem mass spectrometry

Development of an assay method for the detection and quantification of protease and non-nucleoside reverse transcriptase inhibitors in plasma and in peripherical blood mononuclear cells by liquid chromatography coupled with ultraviolet or tandem mass spectrometry detection

Significant levels of intracellular stavudine triphosphate are found in HIV-infected zidovudine-treated patients

In Vitro Primary Human and Animal Cell-Based Blood−Brain Barrier Models as a Screening Tool in Drug Discovery

Predicting plutonium decorporation efficacy after intravenous administration of DTPA formulations : Study of pharmacokinetic-pharmacodynamic relationships in rats

Sensitive and specific LC–ESI–MS/MS method for the determination of a styrylquinoline, BA011FZ041, a potent HIV anti-integrase agent, in rat plasma

Effect of Cell Cycle Arrest on the Activity of Nucleoside Analogues against Human Immunodeficiency Virus Type 1

Evaluation of a six-probe cocktail (caffeine, tolbutamide, omeprazole, dextromethorphan, midazolam, and digoxin) approach to estimate hepatic drug detoxification capability and dosage requirements after a single oral dosing in healthy Chinese volunteers

Direct determination of phosphorylated intracellular anabolites of stavudine (d4T) by liquid chromatography/tandem mass spectrometry

Quantification of the Effects on Viral DNA Synthesis of Reverse Transcriptase Mutations Conferring Human Immunodeficiency Virus Type 1 Resistance to Nucleoside Analogues

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