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Control of protein function through oxidation and reduction of persulfidated states

Science advances, 2020-01, Vol.6 (1), p.eaax8358-eaax8358

2020

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The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death

Cell death & disease, 2015-01, Vol.6 (1), p.e1616-e1616

2015

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ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis

Cell death and differentiation, 2014-04, Vol.21 (4), p.612-623

2014

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APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase

Cell death & disease, 2013-10, Vol.4 (10), p.e881-e881

2013

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Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death

Science advances, 2020-03, Vol.6 (12), p.eaax7945-eaax7945

2020

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Sec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H2O2

Cell death & disease, 2014-05, Vol.5 (5), p.e1235-e1235

2014

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Cisplatin and Oxaliplatin Toxicity: Importance of Cochlear Kinetics as a Determinant for Ototoxicity

JNCI : Journal of the National Cancer Institute, 2009-01, Vol.101 (1), p.37-47

2009

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TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy

Proceedings of the National Academy of Sciences - PNAS, 2019-06, Vol.116 (23), p.11408-11417

2019

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Differential regulation of expression of cytosolic and mitochondrial thioredoxin reductase in rat liver and kidney

Archives of biochemistry and biophysics, 2007-03, Vol.459 (2), p.178-188

2007

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Thioredoxin reductase 1 is upregulated in atherosclerotic plaques: specific induction of the promoter in human macrophages by oxidized low-density lipoproteins

Free radical biology & medicine, 2004-07, Vol.37 (1), p.71-85

2004

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Wobble decoding by the Escherichia coli selenocysteine insertion machinery

Nucleic acids research, 2013-11, Vol.41 (21), p.9800

2013

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The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress

The Journal of biological chemistry, 2003-01, Vol.278 (4), p.2141-2146

2003

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APR-246/PRIMA-1 super(MET) inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase

Cell death & disease, 2013-10, Vol.4, p.e881-e881

2013

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Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues

Biochemical and biophysical research communications, 1992-10, Vol.188 (2), p.712-718

1992

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New developments in recombinant selenoprotein production

Selenium Research for Environment and Human Health: Perspectives, Technologies and Advancements, 2020, p.153-154

1, 2020

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Thymidine and 3'-azido-3'-deoxythymidine metabolism in human peripheral blood lymphocytes and monocyte-derived macrophages. A study of both anabolic and catabolic pathways

The Journal of biological chemistry, 1992-06, Vol.267 (16), p.10968-10975

1992

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Deoxycytidine and 2′,3′-Dideoxycytidine Metabolism in Human Monocyte-Derived Macrophages: A Study of Both Anabolic and Catabolic Pathways

Biochemical and biophysical research communications, 1993-12, Vol.197 (3), p.1499-1504

1993

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Deoxycytidine kinase is constitutively expressed in human lymphocytes: Consequences for compartmentation effects, unscheduled dna synthesis, and viral replication in resting cells

Experimental cell research, 1988-10, Vol.178 (2), p.335-342

1988

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Catabolism of Deoxycytidine in Human Peripheral Blood Mononuclear Cells and Its Interference with the Determination of in Situ Thymidylate Synthase Activity

Analytical biochemistry, 1993-04, Vol.210 (1), p.102-105

1993

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Substrate specificity of mitochondrial 2'-deoxyguanosine kinase

The Journal of biological chemistry, 1993, Vol.268 (30), p.22847-22852

1993

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Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target

PLoS medicine, 2007-06, Vol.4 (6), p.e206-e206

2007

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Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver

Nature communications, 2015-03, Vol.6 (1), p.6479-6479, Article 6479

2015

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Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades

The Journal of biological chemistry, 2019-08, Vol.294 (33), p.12330-12338

2019

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Direct Observation of Methylmercury and Auranofin Binding to Selenocysteine in Thioredoxin Reductase

Inorganic chemistry, 2020-03, Vol.59 (5), p.2711-2718

2020

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NADPH-dependent and -independent disulfide reductase systems

Free radical biology & medicine, 2018-11, Vol.127, p.248-261

2018

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Control of protein function through oxidation and reduction of persulfidated states

The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death

ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis

APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase

Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death

Sec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H2O2

Cisplatin and Oxaliplatin Toxicity: Importance of Cochlear Kinetics as a Determinant for Ototoxicity

TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy

Differential regulation of expression of cytosolic and mitochondrial thioredoxin reductase in rat liver and kidney

Thioredoxin reductase 1 is upregulated in atherosclerotic plaques: specific induction of the promoter in human macrophages by oxidized low-density lipoproteins

Wobble decoding by the Escherichia coli selenocysteine insertion machinery

The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress

APR-246/PRIMA-1 super(MET) inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase

Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues

New developments in recombinant selenoprotein production

Thymidine and 3'-azido-3'-deoxythymidine metabolism in human peripheral blood lymphocytes and monocyte-derived macrophages. A study of both anabolic and catabolic pathways

Deoxycytidine and 2′,3′-Dideoxycytidine Metabolism in Human Monocyte-Derived Macrophages: A Study of Both Anabolic and Catabolic Pathways

Deoxycytidine kinase is constitutively expressed in human lymphocytes: Consequences for compartmentation effects, unscheduled dna synthesis, and viral replication in resting cells

Catabolism of Deoxycytidine in Human Peripheral Blood Mononuclear Cells and Its Interference with the Determination of in Situ Thymidylate Synthase Activity

Substrate specificity of mitochondrial 2'-deoxyguanosine kinase

Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target

Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver

Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades

Direct Observation of Methylmercury and Auranofin Binding to Selenocysteine in Thioredoxin Reductase

NADPH-dependent and -independent disulfide reductase systems

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