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Influence of Affinity and Antigen Internalization on the Uptake and Penetration of Anti-HER2 Antibodies in Solid Tumors

Cancer research (Chicago, Ill.), 2011-03, Vol.71 (6), p.2250-2259

2011

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Impact of intrinsic affinity on functional binding and biological activity of EGFR antibodies

Molecular cancer therapeutics, 2012-07, Vol.11 (7), p.1467-1476

2012

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Broadening of neutralization activity to directly block a dominant antibody-driven SARS-coronavirus evolution pathway

PLoS pathogens, 2008-11, Vol.4 (11), p.e1000197-e1000197

2008

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DeBouganin Diabody Fusion Protein Overcomes Drug Resistance to ADCs Comprised of Anti-Microtubule Agents

Molecules (Basel, Switzerland), 2016-12, Vol.21 (12), p.1741-1741

2016

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Monoclonal antibody therapy of cancer

Nature biotechnology, 2005-09, Vol.23 (9), p.1147-1157

2005

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Targeted Radionuclide Tumor Therapy: Biological Aspects

1. Aufl., 2009

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Monoclonal Antibody Therapy for Cancer

Annual review of medicine, 2003-01, Vol.54 (1), p.343-369

2003

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Anti-CD70 immunocytokines for exploitation of interferon-γ-induced RIP1-dependent necrosis in renal cell carcinoma

PloS one, 2013-04, Vol.8 (4), p.e61446-e61446

2013

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Avidity-Mediated Enhancement of In vivo Tumor Targeting by Single-Chain Fv Dimers

Clinical cancer research, 2006-03, Vol.12 (5), p.1599-1605

2006

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Effective Treatment of Established Human Breast Tumor Xenografts in Immunodeficient Mice with a Single Dose of the α-Emitting Radioisotope Astatine-211 Conjugated to Anti-HER2/neu Diabodies

Clinical cancer research, 2008-02, Vol.14 (3), p.875-882

2008

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Cellular studies of binding, internalization and retention of a radiolabeled EGFR-binding affibody molecule

Nuclear medicine and biology, 2007-08, Vol.34 (6), p.609-618

2007

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Affinity and avidity in antibody-based tumor targeting

Cancer biotherapy & radiopharmaceuticals, 2009-04, Vol.24 (2), p.155

2009

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Ultrasmall Folate Receptor Alpha Targeted Enzymatically Cleavable Silica Nanoparticle Drug Conjugates Augment Penetration and Therapeutic Efficacy in Models of Cancer

ACS nano, 2022-12, Vol.16 (12), p.20021-20033

2022

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CAR T Cells Targeting MISIIR for the Treatment of Ovarian Cancer and Other Gynecologic Malignancies

Molecular therapy, 2020-02, Vol.28 (2), p.548-560

2020

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A single treatment of yttrium-90-labeled CHX-A-c6.5 diabody inhibits the growth of established human tumor xenografts in immunodeficient mice

Cancer research (Chicago, Ill.), 2004-09, Vol.64 (17), p.6200-6206

2004

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Interferon-γ-induced necrosis: an antitumor biotherapeutic perspective

Journal of interferon & cytokine research, 2013-04, Vol.33 (4), p.171

2013

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A rapid method to regenerate piezoelectric microcantilever sensors (PEMS)

Sensors (Basel, Switzerland), 2011-05, Vol.11 (5), p.5520-5528

2011

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Expression of single-chain Fv-Fc fusions in Pichia pastoris

Journal of immunological methods, 2001-05, Vol.251 (1), p.123-135

2001

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Impact of Single-chain Fv Antibody Fragment Affinity on Nanoparticle Targeting of Epidermal Growth Factor Receptor-expressing Tumor Cells

Journal of molecular biology, 2007-08, Vol.371 (4), p.934-947

2007

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Trastuzumab-deBouganin Conjugate Overcomes Multiple Mechanisms of T-DM1 Drug Resistance

Journal of immunotherapy (1997), 2016-04, Vol.39 (3), p.117

2016

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Development of engineered antibodies specific for the Müllerian inhibiting substance type II receptor: a promising candidate for targeted therapy of ovarian cancer

Molecular cancer therapeutics, 2006-08, Vol.5 (8), p.2096-2105

2006

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Single-chain antibody-based immunotoxins targeting Her2/neu: design optimization and impact of affinity on antitumor efficacy and off-target toxicity

Molecular cancer therapeutics, 2012-01, Vol.11 (1), p.143-153

2012

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High affinity restricts the localization and tumor penetration of single-chain Fv antibody molecules

Cancer research (Chicago, Ill.), 2001-06, Vol.61 (12), p.4750-4755

2001

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Molecular Simulation of Receptor Occupancy and Tumor Penetration of an Antibody and Smaller Scaffolds: Application to Molecular Imaging

Molecular imaging and biology, 2017-10, Vol.19 (5), p.656-664

2017

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Influence of Affinity and Antigen Internalization on the Uptake and Penetration of Anti-HER2 Antibodies in Solid Tumors

Impact of intrinsic affinity on functional binding and biological activity of EGFR antibodies

Broadening of neutralization activity to directly block a dominant antibody-driven SARS-coronavirus evolution pathway

DeBouganin Diabody Fusion Protein Overcomes Drug Resistance to ADCs Comprised of Anti-Microtubule Agents

Monoclonal antibody therapy of cancer

Targeted Radionuclide Tumor Therapy: Biological Aspects

Monoclonal Antibody Therapy for Cancer

Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation

Anti-CD70 immunocytokines for exploitation of interferon-γ-induced RIP1-dependent necrosis in renal cell carcinoma

Avidity-Mediated Enhancement of In vivo Tumor Targeting by Single-Chain Fv Dimers

Effective Treatment of Established Human Breast Tumor Xenografts in Immunodeficient Mice with a Single Dose of the α-Emitting Radioisotope Astatine-211 Conjugated to Anti-HER2/neu Diabodies

Cellular studies of binding, internalization and retention of a radiolabeled EGFR-binding affibody molecule

Affinity and avidity in antibody-based tumor targeting

Ultrasmall Folate Receptor Alpha Targeted Enzymatically Cleavable Silica Nanoparticle Drug Conjugates Augment Penetration and Therapeutic Efficacy in Models of Cancer

CAR T Cells Targeting MISIIR for the Treatment of Ovarian Cancer and Other Gynecologic Malignancies

A single treatment of yttrium-90-labeled CHX-A-c6.5 diabody inhibits the growth of established human tumor xenografts in immunodeficient mice

Interferon-γ-induced necrosis: an antitumor biotherapeutic perspective

A rapid method to regenerate piezoelectric microcantilever sensors (PEMS)

Expression of single-chain Fv-Fc fusions in Pichia pastoris

Impact of Single-chain Fv Antibody Fragment Affinity on Nanoparticle Targeting of Epidermal Growth Factor Receptor-expressing Tumor Cells

Trastuzumab-deBouganin Conjugate Overcomes Multiple Mechanisms of T-DM1 Drug Resistance

Development of engineered antibodies specific for the Müllerian inhibiting substance type II receptor: a promising candidate for targeted therapy of ovarian cancer

Single-chain antibody-based immunotoxins targeting Her2/neu: design optimization and impact of affinity on antitumor efficacy and off-target toxicity

High affinity restricts the localization and tumor penetration of single-chain Fv antibody molecules

Molecular Simulation of Receptor Occupancy and Tumor Penetration of an Antibody and Smaller Scaffolds: Application to Molecular Imaging

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