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Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNa v 1.7

The Journal of biological chemistry, 2020-01, Vol.295 (5), p.1315-1327

2020

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The opioid methadone induces a local anaesthetic-like inhibition of the cardiac Na⁺ channel, Na(v)1.5

British journal of pharmacology, 2014-01, Vol.171 (2), p.427

2014

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International Union of Basic and Clinical Pharmacology. XCI. structure, function, and pharmacology of acid-sensing ion channels and the epithelial Na+ channel

Pharmacological reviews, 2015-01, Vol.67 (1), p.1-35

2015

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The Concise Guide to PHARMACOLOGY 2015/16: Voltage‐gated ion channels

British journal of pharmacology, 2015-12, Vol.172 (24), p.5904-5941

2015

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Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockade

The Journal of general physiology, 2007-02, Vol.129 (2), p.161-173

2007

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Anticancer drug oxaliplatin induces acute cooling-aggravated neuropathy via sodium channel subtype Na(V)1.6-resurgent and persistent current

Proceedings of the National Academy of Sciences - PNAS, 2012-04, Vol.109 (17), p.6704

2012

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Inhibition of Protease-Epithelial Sodium Channel Signaling Improves Mucociliary Function in Cystic Fibrosis Airways

American journal of respiratory and critical care medicine, 2016-09, Vol.194 (6), p.701-710

2016

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TRPV4 channels mediate the infrared laser-evoked response in sensory neurons

Journal of neurophysiology, 2012-06, Vol.107 (12), p.3227-3234

2012

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Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET

Proceedings of the National Academy of Sciences - PNAS, 2017-03, Vol.114 (10), p.E1857-E1865

2017

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International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels

Pharmacological reviews, 2005-12, Vol.57 (4), p.397

2005

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Subicular pyramidal neurons gate drug resistance in temporal lobe epilepsy

Annals of neurology, 2019-10, Vol.86 (4), p.626-640

2019

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Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics

The Journal of general physiology, 2013-01, Vol.141 (1), p.61-72

2013

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Scorpion beta-toxins and voltage-gated sodium channels: interactions and effects

Frontiers in bioscience (Landmark. Print), 2013-01, Vol.18 (2), p.572

2013

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Modulation of a voltage-gated Na+channel by sevoflurane involves multiple sites and distinct mechanisms

Proceedings of the National Academy of Sciences - PNAS, 2014-05, Vol.111 (18), p.6726-6731

2014

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Loss-of-Function of the Voltage-Gated Sodium Channel NaV1.5 (Channelopathies) in Patients With Irritable Bowel Syndrome

Gastroenterology (New York, N.Y. 1943), 2014-06, Vol.146 (7), p.1659-1668

2014

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Variability in the efficacy of a standardized antenatal steroid treatment was independent of maternal or fetal plasma drug levels: evidence from a sheep model of pregnancy

American journal of obstetrics and gynecology, 2020-12, Vol.223 (6), p.921.e1-921.e10

2020

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Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain

The Journal of biological chemistry, 2016-07, Vol.291 (27), p.13974-13986

2016

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Ion channels as drug targets: the next GPCRs

The Journal of general physiology, 2008-05, Vol.131 (5), p.399-405

2008

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Regulation of sodium channel function by bilayer elasticity: the importance of hydrophobic coupling. Effects of Micelle-forming amphiphiles and cholesterol

The Journal of general physiology, 2004-05, Vol.123 (5), p.599-621

2004

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Differential effects on fast and slow spindle activity, and the sleep slow oscillation in humans with carbamazepine and flunarizine to antagonize voltage-dependent Na+ and Ca2+ channel activity

Sleep (New York, N.Y.), 2013-06, Vol.36 (6), p.905-911

2013

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An increase in persistent sodium current contributes to intrinsic neuronal bursting after status epilepticus

Journal of neurophysiology, 2011-01, Vol.105 (1), p.117-129

2011

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Naja atra venom peptide reduces pain by selectively blocking the voltage-gated sodium channel Nav1.8

The Journal of biological chemistry, 2019-05, Vol.294 (18), p.7324-7334

2019

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Sodium sensitivity of K Na channels in mouse CA1 neurons

Journal of neurophysiology, 2021-05, Vol.125 (5), p.1690-1697

2021

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Bidirectional influence of sodium channel activation on NMDA receptor–dependent cerebrocortical neuron structural plasticity

Proceedings of the National Academy of Sciences - PNAS, 2012-11, Vol.109 (48), p.19840-19845

2012

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Evidence for a role of Nav1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis

Journal of neurophysiology, 2013-09, Vol.110 (5), p.1144-1157

2013

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1 – 25 von 23.098

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Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNa v 1.7

The opioid methadone induces a local anaesthetic-like inhibition of the cardiac Na⁺ channel, Na(v)1.5

International Union of Basic and Clinical Pharmacology. XCI. structure, function, and pharmacology of acid-sensing ion channels and the epithelial Na+ channel

The Concise Guide to PHARMACOLOGY 2015/16: Voltage‐gated ion channels

Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockade

Anticancer drug oxaliplatin induces acute cooling-aggravated neuropathy via sodium channel subtype Na(V)1.6-resurgent and persistent current

Inhibition of Protease-Epithelial Sodium Channel Signaling Improves Mucociliary Function in Cystic Fibrosis Airways

TRPV4 channels mediate the infrared laser-evoked response in sensory neurons

Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels

Subicular pyramidal neurons gate drug resistance in temporal lobe epilepsy

Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics

Scorpion beta-toxins and voltage-gated sodium channels: interactions and effects

Modulation of a voltage-gated Na+channel by sevoflurane involves multiple sites and distinct mechanisms

Loss-of-Function of the Voltage-Gated Sodium Channel NaV1.5 (Channelopathies) in Patients With Irritable Bowel Syndrome

Variability in the efficacy of a standardized antenatal steroid treatment was independent of maternal or fetal plasma drug levels: evidence from a sheep model of pregnancy

Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain

Ion channels as drug targets: the next GPCRs

Regulation of sodium channel function by bilayer elasticity: the importance of hydrophobic coupling. Effects of Micelle-forming amphiphiles and cholesterol

Differential effects on fast and slow spindle activity, and the sleep slow oscillation in humans with carbamazepine and flunarizine to antagonize voltage-dependent Na+ and Ca2+ channel activity

An increase in persistent sodium current contributes to intrinsic neuronal bursting after status epilepticus

Naja atra venom peptide reduces pain by selectively blocking the voltage-gated sodium channel Nav1.8

Sodium sensitivity of K Na channels in mouse CA1 neurons

Bidirectional influence of sodium channel activation on NMDA receptor–dependent cerebrocortical neuron structural plasticity

Evidence for a role of Nav1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis

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