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Ion channels as drug targets in central nervous system disorders

Current medicinal chemistry, 2013-04, Vol.20 (10), p.1241

2013

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HergSPred: Accurate Classification of hERG Blockers/Nonblockers with Machine-Learning Models

Journal of chemical information and modeling, 2022-04, Vol.62 (8), p.1830-1839

2022

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Effect of nitric oxide-cyclic GMP-K + channel pathway blockers, naloxone and metformin, on the antinociception induced by the diuretic pamabrom

Canadian journal of physiology and pharmacology, 2023-01, Vol.101 (1), p.41

2023

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Facilitation of I Kr current by some hERG channel blockers suppresses early afterdepolarizations

The Journal of general physiology, 2019-02, Vol.151 (2), p.214-230

2019

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COVID-19 Drugs Chloroquine and Hydroxychloroquine, but Not Azithromycin and Remdesivir, Block hERG Potassium Channels

The Journal of pharmacology and experimental therapeutics, 2021-05, Vol.377 (2), p.265

2021

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Phenytoin and phenobarbital inhibit human HERG potassium channels

Epilepsy research, 2003-06, Vol.55 (1), p.147-157

2003

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Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation

Science (American Association for the Advancement of Science), 2010-01, Vol.327 (5963), p.348-351

2010

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Towards a Structural View of Drug Binding to hERG K+ Channels

Trends in pharmacological sciences (Regular ed.), 2017-10, Vol.38 (10), p.899-907

2017

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A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis

Proceedings of the National Academy of Sciences - PNAS, 2023-01, Vol.120 (2), p.e2211977120-e2211977120

2023

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Ions and blockers in potassium channels: insights from free energy simulations

Biochimica et biophysica acta, 2005-02, Vol.1747 (1), p.109-120

2005

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3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

Bioorganic & medicinal chemistry, 2019-04, Vol.27 (7), p.1292-1307

2019

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K Ca channel blockers increase effectiveness of the EGF receptor TK inhibitor erlotinib in non-small cell lung cancer cells (A549)

Scientific reports, 2021-09, Vol.11 (1), p.18330

2021

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Scorpion Potassium Channel-blocking Defensin Highlights a Functional Link with Neurotoxin

The Journal of biological chemistry, 2016-03, Vol.291 (13), p.7097-7106

2016

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N‐terminally extended analogues of the K+ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage‐gated potassium channel Kv1.3

The FEBS journal, 2015-06, Vol.282 (12), p.2247-2259

2015

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Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel K V 1.3: Role of Conformational Dynamics

Journal of chemical information and modeling, 2023-05, Vol.63 (10), p.3043-3053

2023

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A Fluorescent Peptide Toxin for Selective Visualization of the Voltage-Gated Potassium Channel K V 1.3

Bioconjugate chemistry, 2022-11, Vol.33 (11), p.2197-2212

2022

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Potassium Channel Blockade Enhances Atrial Fibrillation-Selective Antiarrhythmic Effects of Optimized State-Dependent Sodium Channel Blockade

Circulation (New York, N.Y.), 2015-12, Vol.132 (23), p.2203-2211

2015

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Citral inhibits the nociception in the rat formalin test: effect of metformin and blockers of opioid receptor and the NO-cGMP-K + channel pathway

Canadian journal of physiology and pharmacology, 2022-04, Vol.100 (4), p.306

2022

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Crystal Structure of the Human K2P TRAAK, a Lipid-and Mechano-Sensitive K⁺ Ion Channel

Science (American Association for the Advancement of Science), 2012-01, Vol.335 (6067), p.436-441

2012

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Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca²⁺ events, and IKCₐ channels, reducing arteriolar tone

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (44), p.18174-18179

2012

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Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses

Nature neuroscience, 2012-03, Vol.15 (3), p.477-486

2012

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Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia

PloS one, 2020-11, Vol.15 (11), p.e0234946

2020

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Virtual screening of DrugBank database for hERG blockers using topological Laplacian-assisted AI models

Computers in biology and medicine, 2023-02, Vol.153, p.106491, Article 106491

2023

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Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment

Pharmacology & therapeutics (Oxford), 2006-07, Vol.111 (1), p.224-259

2006

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8-hydroxypinoresinol-4-O-β-D-glucoside from Valeriana officinalis L. Is a Novel Kv1.5 Channel Blocker

Journal of ethnopharmacology, 2021-08, Vol.276, p.114168-114168, Article 114168

2021

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Ion channels as drug targets in central nervous system disorders

HergSPred: Accurate Classification of hERG Blockers/Nonblockers with Machine-Learning Models

Effect of nitric oxide-cyclic GMP-K + channel pathway blockers, naloxone and metformin, on the antinociception induced by the diuretic pamabrom

Facilitation of I Kr current by some hERG channel blockers suppresses early afterdepolarizations

COVID-19 Drugs Chloroquine and Hydroxychloroquine, but Not Azithromycin and Remdesivir, Block hERG Potassium Channels

Phenytoin and phenobarbital inhibit human HERG potassium channels

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation

Towards a Structural View of Drug Binding to hERG K+ Channels

A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis

Ions and blockers in potassium channels: insights from free energy simulations

3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

K Ca channel blockers increase effectiveness of the EGF receptor TK inhibitor erlotinib in non-small cell lung cancer cells (A549)

Scorpion Potassium Channel-blocking Defensin Highlights a Functional Link with Neurotoxin

N‐terminally extended analogues of the K+ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage‐gated potassium channel Kv1.3

Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel K V 1.3: Role of Conformational Dynamics

A Fluorescent Peptide Toxin for Selective Visualization of the Voltage-Gated Potassium Channel K V 1.3

Potassium Channel Blockade Enhances Atrial Fibrillation-Selective Antiarrhythmic Effects of Optimized State-Dependent Sodium Channel Blockade

Citral inhibits the nociception in the rat formalin test: effect of metformin and blockers of opioid receptor and the NO-cGMP-K + channel pathway

Crystal Structure of the Human K2P TRAAK, a Lipid-and Mechano-Sensitive K⁺ Ion Channel

Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca²⁺ events, and IKCₐ channels, reducing arteriolar tone

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses

Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia

Virtual screening of DrugBank database for hERG blockers using topological Laplacian-assisted AI models

Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment

8-hydroxypinoresinol-4-O-β-D-glucoside from Valeriana officinalis L. Is a Novel Kv1.5 Channel Blocker

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