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Human oncoprotein MDM2 activates the Akt signaling pathway through an interaction with the repressor element-1 silencing transcription factor conferring a survival advantage to cancer cells

Cell death and differentiation, 2013-04, Vol.20 (4), p.558-566

2013

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PI3Kγ is a molecular switch that controls immune suppression

Nature (London), 2016-11, Vol.539 (7629), p.437-442

2016

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Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP2-mediated endocytosis

Nature communications, 2024-03, Vol.15 (1), p.2612-2612

2024

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Phosphoinositide 3-kinase p110δ promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization

Nature communications, 2015-01, Vol.6 (1), p.5937-5937, Article 5937

2015

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A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

Nature (London), 2015-04, Vol.520 (7549), p.683-687

2015

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Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α

Scientific reports, 2023-02, Vol.13 (1), p.1889-1889, Article 1889

2023

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At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy

Nature reviews. Clinical oncology, 2022-07, Vol.19 (7), p.471-485

2022

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Phosphatidylinositol 3-kinase p110δ drives intestinal fibrosis in SHIP deficiency

Mucosal immunology, 2019-09, Vol.12 (5), p.1187-1200

2019

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The role of PI3Kγ in the immune system: new insights and translational implications

Nature reviews. Immunology, 2022-11, Vol.22 (11), p.687

2022

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The interleukin-33-mediated inhibition of expression of two key genes implicated in atherosclerosis in human macrophages requires MAP kinase, phosphoinositide 3-kinase and nuclear factor-κB signaling pathways

Scientific reports, 2019-08, Vol.9 (1), p.11317-12, Article 11317

2019

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Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons

Nature cell biology, 2018-03, Vol.20 (3), p.307

2018

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MYC-targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma

Cell death & disease, 2021-07, Vol.12 (7), p.691-691, Article 691

2021

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Critical roles for the phosphatidylinositide 3-kinase isoforms p110β and p110γ in thrombopoietin-mediated priming of platelet function

Scientific reports, 2019-02, Vol.9 (1), p.1468-1468, Article 1468

2019

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Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells

Nature immunology, 2013-02, Vol.14 (2), p.162

2013

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Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors

Scientific reports, 2022-04, Vol.12 (1), p.5924-5924, Article 5924

2022

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LncRNA AK023948 is a positive regulator of AKT

Nature communications, 2017-02, Vol.8 (1), p.14422-10, Article 14422

2017

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C-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene

Scientific reports, 2019-09, Vol.9 (1), p.12683-14, Article 12683

2019

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Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish

Nature communications, 2018-07, Vol.9 (1), p.2639-13, Article 2639

2018

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Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway

Acta pharmacologica Sinica, 2018-08, Vol.39 (8), p.1294-1304

2018

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MiR-106b and miR-93 regulate cell progression by suppression of PTEN via PI3K/Akt pathway in breast cancer

Cell death & disease, 2017-05, Vol.8 (5), p.e2796-e2796

2017

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TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise

Nature (London), 2020-02, Vol.578 (7796), p.605-609

2020

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Identification of the Binding Sites on Rab5 and p110beta Phosphatidylinositol 3-kinase

Scientific reports, 2017-11, Vol.7 (1), p.16194-13, Article 16194

2017

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Autophagy restricts proliferation driven by oncogenic phosphatidylinositol 3-kinase in three-dimensional culture

Oncogene, 2013-05, Vol.32 (20), p.2543-2554

2013

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The present and future of PI3K inhibitors for cancer therapy

Nature cancer, 2021-06, Vol.2 (6), p.587

2021

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A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy

Nature cell biology, 2015-07, Vol.17 (7), p.930

2015

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Human oncoprotein MDM2 activates the Akt signaling pathway through an interaction with the repressor element-1 silencing transcription factor conferring a survival advantage to cancer cells

PI3Kγ is a molecular switch that controls immune suppression

Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP2-mediated endocytosis

Phosphoinositide 3-kinase p110δ promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α

At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy

Phosphatidylinositol 3-kinase p110δ drives intestinal fibrosis in SHIP deficiency

The role of PI3Kγ in the immune system: new insights and translational implications

The interleukin-33-mediated inhibition of expression of two key genes implicated in atherosclerosis in human macrophages requires MAP kinase, phosphoinositide 3-kinase and nuclear factor-κB signaling pathways

Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons

MYC-targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma

Critical roles for the phosphatidylinositide 3-kinase isoforms p110β and p110γ in thrombopoietin-mediated priming of platelet function

Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells

Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors

LncRNA AK023948 is a positive regulator of AKT

C-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene

Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish

Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway

MiR-106b and miR-93 regulate cell progression by suppression of PTEN via PI3K/Akt pathway in breast cancer

TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise

Identification of the Binding Sites on Rab5 and p110beta Phosphatidylinositol 3-kinase

Autophagy restricts proliferation driven by oncogenic phosphatidylinositol 3-kinase in three-dimensional culture

The present and future of PI3K inhibitors for cancer therapy

A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy

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