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Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized TK-NOG mouse

Xenobiotica, 2021-01, Vol.51 (1), p.51-60

2021

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Evaluation of the Utility of PXB Chimeric Mice for Predicting Human Liver Partitioning of Hepatic Organic Anion-Transporting Polypeptide Transporter Substrates

Drug metabolism and disposition, 2021-03, Vol.49 (3), p.254-264

2021

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In vitro and in vivo induction of cytochrome P450 by coplanar polychlorinated/brominated biphenyls (Co-PXBs) providing high TEQ in mother’s milk in Japan

Toxicology (Amsterdam), 2014-10, Vol.324, p.68-75

2014

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Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l‐lactate transport in the hepatocellular carcinoma cell line

Biopharmaceutics & drug disposition, 2022-10, Vol.43 (5), p.183-191

2022

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Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver

Xenobiotica, 2017-12, Vol.47 (12), p.1052-1063

2017

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Prediction of Human Hepatic Clearance for Cytochrome P450 Substrates via a New Culture Method Using the Collagen Vitrigel Membrane Chamber and Fresh Hepatocytes Isolated from Liver Humanized Mice

Biological and Pharmaceutical Bulletin, 2019/03/01, Vol.42(3), pp.348-353

2019

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Prediction of human pharmacokinetics of long half-life compounds using chimeric mice with humanised liver

Xenobiotica, 2019-12, Vol.49 (12), p.1379-1387

2019

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Consideration of Commercially Available Hepatocytes as Cell Sources for Liver-Microphysiological Systems by Comparing Liver Characteristics

Pharmaceutics, 2022-12, Vol.15 (1), p.55

2022

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Anti-Tumor Activity and Underlying Mechanism of Phomoxanthone B in MCF7 Cells

Anti-cancer agents in medicinal chemistry, 2021-01, Vol.21 (14), p.1825

2021

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Evaluation of the Utility of Chimeric Mice with Humanized Livers for the Characterization and Profiling of the Metabolites of a Selective Inhibitor (YM543) of the Sodium-Glucose Cotransporter 2

Pharmaceutical research, 2017-04, Vol.34 (4), p.874-886

Nakada, Naoyuki

2017

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Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers

Xenobiotica, 2012-06, Vol.42 (6), p.503-517

2012

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Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers

Xenobiotica, 2012-11, Vol.42 (11), p.1128-1137

2012

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Troglitazone metabolism and transporter effects in chimeric mice: a comparison between chimeric humanized and chimeric murinized FRG mice

Xenobiotica, 2014-02, Vol.44 (2), p.186-195

2014

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Polymyxin B self-associated with phospholipid nanomicelles

Pharmaceutical development and technology, 2012-11, Vol.17 (6), p.654-660

2012

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Prediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes

Xenobiotica, 2013-11, Vol.43 (11), p.956-962

2013

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Quantitative prediction of CYP3A‐mediated drug–drug interactions by correctly estimating fraction metabolized using human liver chimeric mice

British journal of pharmacology, 2024-04, Vol.181 (7), p.1091-1106

2024

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In vitro evaluation of nebulization properties, antimicrobial activity, and regional airway surface liquid concentration of liposomal polymyxin B sulfate

Pharmaceutical research, 2003-03, Vol.20 (3), p.442-447

2003

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Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver

Xenobiotica, 2015-07, Vol.45 (7), p.605-614

2015

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Organic Anion-Transporting Polypeptide (OATP)-Mediated Drug-Drug Interaction Study between Rosuvastatin and Cyclosporine A in Chimeric Mice with Humanized Liver

Drug metabolism and disposition, 2018-01, Vol.46 (1), p.11-19

2018

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Murine Cyp3a knockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans

Biopharmaceutics & drug disposition, 2016-01, Vol.37 (1), p.3-14

2016

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Effect of Rifampicin on the Plasma Concentrations of Bile Acid-O-Sulfates in Monkeys and Human Liver-Transplanted Chimeric Mice With or Without Bile Flow Diversion

Journal of pharmaceutical sciences, 2019-08, Vol.108 (8), p.2756-2764

2019

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Prediction of human metabolism of FK3453 by aldehyde oxidase using chimeric mice transplanted with human or rat hepatocytes

Drug metabolism and disposition, 2012-01, Vol.40 (1), p.76

2012

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Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver

Drug metabolism and disposition, 2020-10, Vol.48 (10), p.934-943

2020

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Endogenous and xenobiotic metabolite profiling of liver extracts from SCID and chimeric humanized mice following repeated oral administration of troglitazone

Xenobiotica, 2014-02, Vol.44 (2), p.174-185

2014

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Anti-HBV activity of retinoid drugs in vitro versus in vivo

Antiviral research, 2019-09, Vol.169, p.104538-104538, Article 104538

2019

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Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized TK-NOG mouse

Evaluation of the Utility of PXB Chimeric Mice for Predicting Human Liver Partitioning of Hepatic Organic Anion-Transporting Polypeptide Transporter Substrates

In vitro and in vivo induction of cytochrome P450 by coplanar polychlorinated/brominated biphenyls (Co-PXBs) providing high TEQ in mother’s milk in Japan

Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l‐lactate transport in the hepatocellular carcinoma cell line

Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver

Prediction of Human Hepatic Clearance for Cytochrome P450 Substrates via a New Culture Method Using the Collagen Vitrigel Membrane Chamber and Fresh Hepatocytes Isolated from Liver Humanized Mice

Prediction of human pharmacokinetics of long half-life compounds using chimeric mice with humanised liver

Consideration of Commercially Available Hepatocytes as Cell Sources for Liver-Microphysiological Systems by Comparing Liver Characteristics

Anti-Tumor Activity and Underlying Mechanism of Phomoxanthone B in MCF7 Cells

Evaluation of the Utility of Chimeric Mice with Humanized Livers for the Characterization and Profiling of the Metabolites of a Selective Inhibitor (YM543) of the Sodium-Glucose Cotransporter 2

Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers

Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers

Troglitazone metabolism and transporter effects in chimeric mice: a comparison between chimeric humanized and chimeric murinized FRG mice

Polymyxin B self-associated with phospholipid nanomicelles

Prediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes

Quantitative prediction of CYP3A‐mediated drug–drug interactions by correctly estimating fraction metabolized using human liver chimeric mice

In vitro evaluation of nebulization properties, antimicrobial activity, and regional airway surface liquid concentration of liposomal polymyxin B sulfate

Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver

Organic Anion-Transporting Polypeptide (OATP)-Mediated Drug-Drug Interaction Study between Rosuvastatin and Cyclosporine A in Chimeric Mice with Humanized Liver

Murine Cyp3a knockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans

Effect of Rifampicin on the Plasma Concentrations of Bile Acid-O-Sulfates in Monkeys and Human Liver-Transplanted Chimeric Mice With or Without Bile Flow Diversion

Prediction of human metabolism of FK3453 by aldehyde oxidase using chimeric mice transplanted with human or rat hepatocytes

Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver

Endogenous and xenobiotic metabolite profiling of liver extracts from SCID and chimeric humanized mice following repeated oral administration of troglitazone

Anti-HBV activity of retinoid drugs in vitro versus in vivo

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