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The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization

Journal of molecular biology, 2014-04, Vol.426 (8), p.1848-1860

2014

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Molecular interactions at the colchicine binding site in tubulin: An X-ray crystallography perspective

Drug discovery today, 2022-03, Vol.27 (3), p.759-776

2022

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Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery

The FEBS journal, 2016-01, Vol.283 (1), p.102-111

2016

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Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth

Journal of medicinal chemistry, 2016-10, Vol.59 (19), p.8685-8711

2016

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Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.1031-1044

2018

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Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent

Molecular cell, 2017-10, Vol.68 (1), p.210-223.e6

2017

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Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics

PloS one, 2016-08, Vol.11 (8), p.e0160890-e0160890

2016

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Novel 1,2,4-triazole derivatives as potential anticancer agents: Design, synthesis, molecular docking and mechanistic studies

Bioorganic chemistry, 2018-02, Vol.76, p.314-325

2018

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Taxol ® : The First Microtubule Stabilizing Agent

International journal of molecular sciences, 2017-08, Vol.18 (8), p.1733

2017

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Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures

Future medicinal chemistry, 2017-10, Vol.9 (15), p.1765-1794

2017

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Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activities

European journal of medicinal chemistry, 2014-11, Vol.87, p.306-315

2014

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Microtubule Targeting Agents as Cancer Chemotherapeutics: An Overview of Molecular Hybrids as Stabilizing and Destabilizing Agents

Current topics in medicinal chemistry, 2017-09, Vol.17 (22), p.2523

2017

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Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

Science (American Association for the Advancement of Science), 2013-02, Vol.339 (6119), p.587-590

2013

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Natural antitubulin agents: Importance of 3,4,5-trimethoxyphenyl fragment

Bioorganic & medicinal chemistry, 2015-02, Vol.23 (3), p.373-389

2015

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Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

Nature communications, 2017-03, Vol.8 (1), p.14683-14683, Article 14683

2017

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Purification, Characterization, and in Vitro Activity of 2,4-Di-tert-butylphenol from Pseudomonas monteilii PsF84: Conformational and Molecular Docking Studies

Journal of agricultural and food chemistry, 2014-07, Vol.62 (26), p.6138-6146

2014

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Design, synthesis and anticancer properties of IsoCombretaQuinolines as potent tubulin assembly inhibitors

European journal of medicinal chemistry, 2017-02, Vol.127, p.1025-1034

2017

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Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy

Molecules (Basel, Switzerland), 2017-08, Vol.22 (8), p.1281

2017

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new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs

Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (38), p.13817-13821

2014

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Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities

European journal of medicinal chemistry, 2020-09, Vol.202, p.112519, Article 112519

2020

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SB226, an inhibitor of tubulin polymerization, inhibits paclitaxel-resistant melanoma growth and spontaneous metastasis

Cancer letters, 2023-02, Vol.555, p.216046-216046, Article 216046

2023

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Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site

Journal of medicinal chemistry, 2022-12, Vol.65 (24), p.16372-16391

2022

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Potent combretastatin A-4 analogs containing 1,2,4-triazole: Synthesis, antiproliferative, anti-tubulin activity, and docking study

European journal of medicinal chemistry, 2019-12, Vol.183, p.111697-111697, Article 111697

2019

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Microtubule-targeting agents are clinically successful due to both mitotic and interphase impairment of microtubule function

Bioorganic & medicinal chemistry, 2014-09, Vol.22 (18), p.5050-5059

2014

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Recent Advances in Combretastatin A-4 Inspired Inhibitors of Tubulin Polymerization: An Update

Current medicinal chemistry, 2022-06, Vol.29 (20), p.3557-3585

Baytas, Sultan Nacak

2022

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The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization

Molecular interactions at the colchicine binding site in tubulin: An X-ray crystallography perspective

Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery

Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth

Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure

Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent

Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics

Novel 1,2,4-triazole derivatives as potential anticancer agents: Design, synthesis, molecular docking and mechanistic studies

Taxol ® : The First Microtubule Stabilizing Agent

Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures

Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activities

Microtubule Targeting Agents as Cancer Chemotherapeutics: An Overview of Molecular Hybrids as Stabilizing and Destabilizing Agents

Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

Natural antitubulin agents: Importance of 3,4,5-trimethoxyphenyl fragment

Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

Purification, Characterization, and in Vitro Activity of 2,4-Di-tert-butylphenol from Pseudomonas monteilii PsF84: Conformational and Molecular Docking Studies

Design, synthesis and anticancer properties of IsoCombretaQuinolines as potent tubulin assembly inhibitors

Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy

new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs

Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities

SB226, an inhibitor of tubulin polymerization, inhibits paclitaxel-resistant melanoma growth and spontaneous metastasis

Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site

Potent combretastatin A-4 analogs containing 1,2,4-triazole: Synthesis, antiproliferative, anti-tubulin activity, and docking study

Microtubule-targeting agents are clinically successful due to both mitotic and interphase impairment of microtubule function

Recent Advances in Combretastatin A-4 Inspired Inhibitors of Tubulin Polymerization: An Update

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