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Application of sulfoximines in medicinal chemistry from 2013 to 2020

European journal of medicinal chemistry, 2021-01, Vol.209, p.112885, Article 112885

2021

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Clinical Outcomes and Plasma Concentrations of Baloxavir Marboxil and Favipiravir in COVID-19 Patients: An Exploratory Randomized, Controlled Trial

European journal of pharmaceutical sciences, 2021-02, Vol.157, p.105631-105631, Article 105631

2021

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Safety and efficacy of avapritinib in advanced systemic mastocytosis: the phase 1 EXPLORER trial

Nature medicine, 2021-12, Vol.27 (12), p.2183-2191

2021

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The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy

Neuropharmacology, 2018-09, Vol.140, p.107-120

2018

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Baloxavir: First Global Approval

Drugs (New York, N.Y.), 2018-04, Vol.78 (6), p.693-697

Heo, Young-A

2018

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Discovery of 1,2,4-triazine derivatives as adenosine A(2A) antagonists using structure based drug design

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.1898

2012

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Human Metabolite Lamotrigine-N(2)-glucuronide Is the Principal Source of Lamotrigine-Derived Compounds in Wastewater Treatment Plants and Surface Water

Environmental science & technology, 2016-01, Vol.50 (1), p.154-164

2016

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Lamotrigine kinetics within the menstrual cycle, after menopause, and with oral contraceptives

Neurology, 2009-10, Vol.73 (17), p.1388

2009

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Generic-to-generic lamotrigine switches in people with epilepsy: the randomised controlled EQUIGEN trial

Lancet neurology, 2016-04, Vol.15 (4), p.365-372

2016

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Discovery of (S)‑1-(1-(Imidazo[1,2‑a]pyridin-6-yl)ethyl)-6-(1-methyl‑1H‑pyrazol-4-yl)‑1H‑[1,2,3]triazolo[4,5‑b]pyrazine (Volitinib) as a Highly Potent and Selective Mesenchymal–Epithelial Transition Factor (c-Met) Inhibitor in Clinical Development for Treatment of Cancer

Journal of medicinal chemistry, 2014-09, Vol.57 (18), p.7577-7589

2014

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SOP Conservative (Medical and Mechanical) Treatment of Erectile Dysfunction

Journal of sexual medicine, 2013-01, Vol.10 (1), p.130-171

2013

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Discovering Drugs with DNA‐Encoded Library Technology: From Concept to Clinic with an Inhibitor of Soluble Epoxide Hydrolase

Chembiochem : a European journal of chemical biology, 2017-05, Vol.18 (9), p.837-842

2017

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Bioequivalence Between Generic and Branded Lamotrigine in People With Epilepsy: The EQUIGEN Randomized Clinical Trial

JAMA neurology, 2017-08, Vol.74 (8), p.919

2017

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Synthesis and Biological Evaluation of Novel Triazine Derivatives as Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors

Journal of medicinal chemistry, 2021-08, Vol.64 (16), p.12379-12396

2021

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Investigating the interaction between melamine and cyanuric acid using a Physiologically-Based Toxicokinetic model in rainbow trout

Toxicology and applied pharmacology, 2019-05, Vol.370, p.184-195

2019

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Pharmacotherapy for mood disorders in pregnancy: a review of pharmacokinetic changes and clinical recommendations for therapeutic drug monitoring

Journal of clinical psychopharmacology, 2014-04, Vol.34 (2), p.244-255

2014

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Pharmacokinetics of lamotrigine and its metabolite N‐2‐glucuronide: Influence of polymorphism of UDP‐glucuronosyltransferases and drug transporters

British journal of clinical pharmacology, 2016-08, Vol.82 (2), p.399-411

2016

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Design, Synthesis, Formulation, and Bioevaluation of Trisubstituted Triazines as Highly Selective mTOR Inhibitors for the Treatment of Human Breast Cancer

Journal of medicinal chemistry, 2024-05, Vol.67 (9), p.7330-7358

2024

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Phase I dose‐escalation study of capmatinib (INC280) in Japanese patients with advanced solid tumors

Cancer science, 2019-04, Vol.110 (4), p.1340-1351

2019

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The corticotropin releasing hormone-1 (CRH1) receptor antagonist pexacerfont in alcohol dependence: a randomized controlled experimental medicine study

Neuropsychopharmacology (New York, N.Y.), 2015-03, Vol.40 (5), p.1053-1063

2015

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Aerosol Inhalation Delivery of Triazavirin in Mice: Outlooks for Advanced Therapy Against Novel Viral Infections

Journal of pharmaceutical sciences, 2021-03, Vol.110 (3), p.1316-1322

2021

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Quantification of plasma remdesivir and its metabolite GS-441524 using liquid chromatography coupled to tandem mass spectrometry. Application to a Covid-19 treated patient

Clinical chemistry and laboratory medicine, 2020-08, Vol.58 (9), p.1461

2020

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Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines

Journal of medicinal chemistry, 2021-04, Vol.64 (7), p.4150-4162

2021

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Dose-dependent effect of lamotrigine on quetiapine serum concentration in patients using instant release tablets

European journal of clinical pharmacology, 2024-06, Vol.80 (6), p.839-845

2024

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Application of sulfoximines in medicinal chemistry from 2013 to 2020

Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia

Clinical Outcomes and Plasma Concentrations of Baloxavir Marboxil and Favipiravir in COVID-19 Patients: An Exploratory Randomized, Controlled Trial

Safety and efficacy of avapritinib in advanced systemic mastocytosis: the phase 1 EXPLORER trial

The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy

Baloxavir: First Global Approval

Discovery of 1,2,4-triazine derivatives as adenosine A(2A) antagonists using structure based drug design

Human Metabolite Lamotrigine-N(2)-glucuronide Is the Principal Source of Lamotrigine-Derived Compounds in Wastewater Treatment Plants and Surface Water

Lamotrigine kinetics within the menstrual cycle, after menopause, and with oral contraceptives

Generic-to-generic lamotrigine switches in people with epilepsy: the randomised controlled EQUIGEN trial

Discovery of (S)‑1-(1-(Imidazo[1,2‑a]pyridin-6-yl)ethyl)-6-(1-methyl‑1H‑pyrazol-4-yl)‑1H‑[1,2,3]triazolo[4,5‑b]pyrazine (Volitinib) as a Highly Potent and Selective Mesenchymal–Epithelial Transition Factor (c-Met) Inhibitor in Clinical Development for Treatment of Cancer

SOP Conservative (Medical and Mechanical) Treatment of Erectile Dysfunction

Discovering Drugs with DNA‐Encoded Library Technology: From Concept to Clinic with an Inhibitor of Soluble Epoxide Hydrolase

Bioequivalence Between Generic and Branded Lamotrigine in People With Epilepsy: The EQUIGEN Randomized Clinical Trial

Synthesis and Biological Evaluation of Novel Triazine Derivatives as Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors

Investigating the interaction between melamine and cyanuric acid using a Physiologically-Based Toxicokinetic model in rainbow trout

Pharmacotherapy for mood disorders in pregnancy: a review of pharmacokinetic changes and clinical recommendations for therapeutic drug monitoring

Pharmacokinetics of lamotrigine and its metabolite N‐2‐glucuronide: Influence of polymorphism of UDP‐glucuronosyltransferases and drug transporters

Design, Synthesis, Formulation, and Bioevaluation of Trisubstituted Triazines as Highly Selective mTOR Inhibitors for the Treatment of Human Breast Cancer

Phase I dose‐escalation study of capmatinib (INC280) in Japanese patients with advanced solid tumors

The corticotropin releasing hormone-1 (CRH1) receptor antagonist pexacerfont in alcohol dependence: a randomized controlled experimental medicine study

Aerosol Inhalation Delivery of Triazavirin in Mice: Outlooks for Advanced Therapy Against Novel Viral Infections

Quantification of plasma remdesivir and its metabolite GS-441524 using liquid chromatography coupled to tandem mass spectrometry. Application to a Covid-19 treated patient

Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines

Dose-dependent effect of lamotrigine on quetiapine serum concentration in patients using instant release tablets

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