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Protection of mammalian telomeres

Oncogene, 2002-01, Vol.21 (4), p.532-540

de Lange, T

2002

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GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability

Nature cell biology, 2018-04, Vol.20 (4), p.492

2018

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TERRA G-quadruplex RNA interaction with TRF2 GAR domain is required for telomere integrity

Scientific reports, 2021-02, Vol.11 (1), p.3509-3509, Article 3509

2021

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A heterochromatin-dependent transcription machinery drives piRNA expression

Nature (London), 2017-09, Vol.549 (7670), p.54-59

2017

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Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2

The EMBO journal, 2019-06, Vol.38 (11), p.n/a

2019

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Structural biology of telomeres and telomerase

Cellular and molecular life sciences : CMLS, 2020-01, Vol.77 (1), p.61-79

2020

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Homology directed telomere clustering, ultrabright telomere formation and nuclear envelope rupture in cells lacking TRF2B and RAP1

Nature communications, 2023-04, Vol.14 (1), p.2144-20, Article 2144

2023

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TRF2 cooperates with CTCF for controlling the oncomiR-193b-3p in colorectal cancer

Cancer letters, 2022-05, Vol.533, p.215607-215607, Article 215607

2022

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Mammalian telomeric RNA (TERRA) can be translated to produce valine-arginine and glycine-leucine dipeptide repeat proteins

Proceedings of the National Academy of Sciences - PNAS, 2023-02, Vol.120 (9), p.e2221529120-e2221529120

2023

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Fate of telomere entanglements is dictated by the timing of anaphase midregion nuclear envelope breakdown

Nature communications, 2024-06, Vol.15 (1), p.4707-4707, Article 4707

2024

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CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle

Nature (London), 2019-11, Vol.575 (7783), p.523-527

2019

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Shelterin is a dimeric complex with extensive structural heterogeneity

Proceedings of the National Academy of Sciences - PNAS, 2022-08, Vol.119 (31), p.1-e2201662119

2022

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MiR‐182‐3p targets TRF2 and impairs tumor growth of triple‐negative breast cancer

EMBO molecular medicine, 2023-01, Vol.15 (1), p.e16033-n/a

2023

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Drug repositioning strategy for the identification of novel telomere-damaging agents: A role for NAMPT inhibitors

Aging cell, 2023-11, Vol.22 (11), p.e13944-e13944

2023

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TRF2-independent chromosome end protection during pluripotency

Nature (London), 2021-01, Vol.589 (7840), p.103-109

2021

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TRF2-mediated telomere protection is dispensable in pluripotent stem cells

Nature (London), 2021-01, Vol.589 (7840), p.110-115

2021

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Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity

Nature communications, 2017-10, Vol.8 (1), p.1075-14, Article 1075

2017

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The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats

Cell research, 2011-07, Vol.21 (7), p.1028-1038

2011

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The Intra- and Extra-Telomeric Role of TRF2 in the DNA Damage Response

International journal of molecular sciences, 2021-09, Vol.22 (18), p.9900

2021

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ZNF524 directly interacts with telomeric DNA and supports telomere integrity

Nature communications, 2023-12, Vol.14 (1), p.8252-8252, Article 8252

2023

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TRF2 binds branched DNA to safeguard telomere integrity

Nature structural & molecular biology, 2017-09, Vol.24 (9), p.734

2017

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TRF1 and TRF2: pioneering targets in telomere-based cancer therapy

Journal of cancer research and clinical oncology, 2024-07, Vol.150 (7), p.353, Article 353

2024

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TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops

Nature structural & molecular biology, 2018-02, Vol.25 (2), p.147

2018

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TRF2 recruits nucleolar protein TCOF1 to coordinate telomere transcription and replication

Cell death and differentiation, 2021-03, Vol.28 (3), p.1062-1075

2021

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In Vitro Characterization of the Physical Interactions between the Long Noncoding RNA TERRA and the Telomeric Proteins TRF1 and TRF2

International journal of molecular sciences, 2022-09, Vol.23 (18), p.10463

2022

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Protection of mammalian telomeres

GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability

TERRA G-quadruplex RNA interaction with TRF2 GAR domain is required for telomere integrity

A heterochromatin-dependent transcription machinery drives piRNA expression

Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2

Structural biology of telomeres and telomerase

Homology directed telomere clustering, ultrabright telomere formation and nuclear envelope rupture in cells lacking TRF2B and RAP1

TRF2 cooperates with CTCF for controlling the oncomiR-193b-3p in colorectal cancer

Mammalian telomeric RNA (TERRA) can be translated to produce valine-arginine and glycine-leucine dipeptide repeat proteins

Fate of telomere entanglements is dictated by the timing of anaphase midregion nuclear envelope breakdown

CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle

Shelterin is a dimeric complex with extensive structural heterogeneity

MiR‐182‐3p targets TRF2 and impairs tumor growth of triple‐negative breast cancer

Drug repositioning strategy for the identification of novel telomere-damaging agents: A role for NAMPT inhibitors

TRF2-independent chromosome end protection during pluripotency

TRF2-mediated telomere protection is dispensable in pluripotent stem cells

Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity

The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats

The Intra- and Extra-Telomeric Role of TRF2 in the DNA Damage Response

ZNF524 directly interacts with telomeric DNA and supports telomere integrity

TRF2 binds branched DNA to safeguard telomere integrity

TRF1 and TRF2: pioneering targets in telomere-based cancer therapy

TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops

TRF2 recruits nucleolar protein TCOF1 to coordinate telomere transcription and replication

In Vitro Characterization of the Physical Interactions between the Long Noncoding RNA TERRA and the Telomeric Proteins TRF1 and TRF2

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