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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction

Proceedings of the National Academy of Sciences - PNAS, 2019-02, Vol.116 (7), p.2551-2560

2019

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Targeting protein-protein interaction by small molecules

Annual review of pharmacology and toxicology, 2014-01, Vol.54 (1), p.435-456

2014

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Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules

Cell, 2021-05, Vol.184 (10), p.2649-2664.e18

2021

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Severe Lymphatic Disorder Resolved With MEK Inhibition in a Patient With Noonan Syndrome and SOS1 Mutation

Pediatrics (Evanston), 2020-12, Vol.146 (6), p.1

2020

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High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling

Analytical biochemistry, 2018-05, Vol.548 (C), p.44-52

2018

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The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation

Current opinion in genetics & development, 2009-06, Vol.19 (3), p.230-236

2009

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Downregulated Gene Expression Spectrum and Immune Responses Changed During the Disease Progression in Patients With COVID-19

Clinical infectious diseases, 2020-11, Vol.71 (16), p.2052-2060

2020

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High-Affinity Interactions of the nSH3/cSH3 Domains of Grb2 with the C‑Terminal Proline-Rich Domain of SOS1

Journal of the American Chemical Society, 2020-02, Vol.142 (7), p.3401-3411

2020

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RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers

Nature cell biology, 2018-09, Vol.20 (9), p.1064-1073

2018

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Allosteric nanobodies to study the interactions between SOS1 and RAS

Nature communications, 2024-07, Vol.15 (1), p.6214-10, Article 6214

2024

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Identifying Potential SOS1 Inhibitors via Virtual Screening of Multiple Small Molecule Libraries against KRAS‐SOS1 Interaction

Chembiochem : a European journal of chemical biology, 2024-06, Vol.25 (12), p.e202400008-n/a

2024

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Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices

Proceedings of the National Academy of Sciences - PNAS, 2015-02, Vol.112 (6), p.1761-1766

2015

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Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods

Journal of medicinal chemistry, 2020-08, Vol.63 (15), p.8325-8337

2020

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Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation

Journal of medicinal chemistry, 2015-03, Vol.58 (5), p.2265-2274

2015

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Allosteric KRas4B Can Modulate SOS1 Fast and Slow Ras Activation Cycles

Biophysical journal, 2018-08, Vol.115 (4), p.629-641

2018

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Development of Son of Sevenless Homologue 1 (SOS1) Modulators To Treat Cancers by Regulating RAS Signaling

Journal of medicinal chemistry, 2023-04, Vol.66 (7), p.4324-4341

2023

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Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange

Proceedings of the National Academy of Sciences - PNAS, 2014-03, Vol.111 (9), p.3401-3406

2014

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SOS1 gene family in mangrove (Kandelia obovata): Genome-wide identification, characterization, and expression analyses under salt and copper stress

BMC plant biology, 2024-08, Vol.24 (1), p.805-19

2024

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Constitutive high-level SOS1 expression and absence of HKT1;1 expression in the salt-accumulating halophyte Salicornia dolichostachya

Plant science (Limerick), 2015-05, Vol.234, p.144-154

2015

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SOS1-inspired hydrocarbon-stapled peptide as a pan-Ras inhibitor

Bioorganic chemistry, 2023-06, Vol.135, p.106500-106500, Article 106500

2023

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Design, synthesis, and bioevaluation of SOS1 PROTACs derived from pyrido[2,3-d]pyrimidin-7-one-based SOS1 inhibitor

Bioorganic & medicinal chemistry letters, 2024-07, Vol.107, p.129780-129780, Article 129780

2024

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Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS

Journal of medicinal chemistry, 2018-10, Vol.61 (19), p.8875-8894

2018

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SOS1 gene overexpression increased salt tolerance in transgenic tobacco by maintaining a higher K +/Na + ratio

Journal of plant physiology, 2012-02, Vol.169 (3), p.255-261

2012

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Critical requirement of SOS1 RAS-GEF function for mitochondrial dynamics, metabolism, and redox homeostasis

Oncogene, 2021-07, Vol.40 (27), p.4538-4551

2021

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Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos

Nature cell biology, 2007-06, Vol.9 (6), p.707-712

2007

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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction

Targeting protein-protein interaction by small molecules

Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules

Severe Lymphatic Disorder Resolved With MEK Inhibition in a Patient With Noonan Syndrome and SOS1 Mutation

High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling

The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation

Downregulated Gene Expression Spectrum and Immune Responses Changed During the Disease Progression in Patients With COVID-19

High-Affinity Interactions of the nSH3/cSH3 Domains of Grb2 with the C‑Terminal Proline-Rich Domain of SOS1

RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers

Allosteric nanobodies to study the interactions between SOS1 and RAS

Identifying Potential SOS1 Inhibitors via Virtual Screening of Multiple Small Molecule Libraries against KRAS‐SOS1 Interaction

Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices

Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods

Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation

Allosteric KRas4B Can Modulate SOS1 Fast and Slow Ras Activation Cycles

Development of Son of Sevenless Homologue 1 (SOS1) Modulators To Treat Cancers by Regulating RAS Signaling

Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange

SOS1 gene family in mangrove (Kandelia obovata): Genome-wide identification, characterization, and expression analyses under salt and copper stress

Constitutive high-level SOS1 expression and absence of HKT1;1 expression in the salt-accumulating halophyte Salicornia dolichostachya

SOS1-inspired hydrocarbon-stapled peptide as a pan-Ras inhibitor

Design, synthesis, and bioevaluation of SOS1 PROTACs derived from pyrido[2,3-d]pyrimidin-7-one-based SOS1 inhibitor

Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS

SOS1 gene overexpression increased salt tolerance in transgenic tobacco by maintaining a higher K +/Na + ratio

Critical requirement of SOS1 RAS-GEF function for mitochondrial dynamics, metabolism, and redox homeostasis

Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos

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