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Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells

Cell reports (Cambridge), 2018-04, Vol.23 (1), p.58-67

2018

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Deguelin targets multiple oncogenic signaling pathways to combat human malignancies

Pharmacological research, 2021-04, Vol.166, p.105487-105487, Article 105487

2021

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Pharmacological basis and new insights of deguelin concerning its anticancer effects

Pharmacological research, 2021-12, Vol.174, p.105935-105935, Article 105935

2021

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Biopharmacological considerations for accelerating drug development of deguelin, a rotenoid with potent chemotherapeutic and chemopreventive potential

Cancer, 2019-06, Vol.125 (11), p.1789-1798

2019

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Regulation of the Endogenous Opiate Signaling Pathway against Oxidative Stress and Inflammation: A Considerable Approach for Exploring Preclinical Treatment of Parkinson’s Disease

Pharmacology, 2023-11, Vol.108 (6), p.550-564

2023

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Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein

Scientific reports, 2022-12, Vol.12 (1), p.21951-16, Article 21951

2022

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Neuroprotective effects of linagliptin in a rotenone-induced rat model of Parkinson's disease

Indian journal of pharmacology, 2022-01, Vol.54 (1), p.46-50

2022

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Anticancer efficacy of deguelin in human prostate cancer cells targeting glycogen synthase kinase‐3 β/β‐catenin pathway

International journal of cancer, 2011-12, Vol.129 (12), p.2916-2927

2011

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Tephrosin attenuates sepsis induced acute lung injury in rats by impeding expression of ICAM-1 and MIP-2

Microbial pathogenesis, 2018-04, Vol.117, p.93-99

2018

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The Natural Rotenoid Deguelin Ameliorates Diabetic Neuropathy by Decreasing Oxidative Stress and Plasma Glucose Levels in Rats via the Nrf2 Signalling Pathway

Cellular physiology and biochemistry, 2018-08, Vol.48 (3), p.1164-1176

2018

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The Role of the Akt/mTOR Pathway in Tobacco Carcinogen–Induced Lung Tumorigenesis

Clinical cancer research, 2010-01, Vol.16 (1), p.4-10

2010

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Rotenone restrains colon cancer cell viability, motility and epithelial‑mesenchymal transition and tumorigenesis in nude mice via the PI3K/AKT pathway

International journal of molecular medicine, 2020-08, Vol.46 (2), p.700-708

2020

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Millettia pachycarpa exhibits anti-inflammatory activity through the suppression of LPS-induced NO/iNOS expression

The American journal of Chinese medicine (1979), 2014, Vol.42 (4), p.949-965

2014

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Deguelin Attenuates Allergic Airway Inflammation via Inhibition of NF-κb Pathway in Mice

International journal of biological sciences, 2017-01, Vol.13 (4), p.492-504

2017

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Rotenone Remarkably Attenuates Oxidative Stress, Inflammation, and Fibrosis in Chronic Obstructive Uropathy

Mediators of Inflammation, 2014-01, Vol.2014 (6), p.377-385

2014

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Deguelin, a Novel Anti-Tumorigenic Agent in Human Esophageal Squamous Cell Carcinoma

EBioMedicine, 2017-12, Vol.26 (C), p.10-10

2017

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Role for pAKT in rat urinary bladder with cyclophosphamide (CYP)-induced cystitis

American journal of physiology. Renal physiology, 2011-08, Vol.301 (2), p.F252-F262

2011

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Antiangiogenic effect of deguelin on choroidal neovascularization

The Journal of pharmacology and experimental therapeutics, 2008-02, Vol.324 (2), p.643-647

2008

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Deguelin and Its Role in Chronic Diseases

Advances in experimental medicine and biology, 2016, Vol.929, p.363-375

2016

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Deguelin, A PI3K/AKT inhibitor, enhances chemosensitivity of leukaemia cells with an active PI3K/AKT pathway

British journal of haematology, 2005-06, Vol.129 (5), p.677-686

2005

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Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat

PloS one, 2012-06, Vol.7 (6), p.e39265

2012

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Evaluation of anti-bacterial and wound healing activity of the fruits of Amorpha fruticosa L

African journal of traditional, complementary, and alternative medicines, 2013-01, Vol.10 (3), p.458-468

2013

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Efficacy of Deguelin and Silibinin on Benzo(a)pyrene-Induced Lung Tumorigenesis in A/J Mice

Neoplasia (New York, N.Y.), 2005-12, Vol.7 (12), p.1053-1057

2005

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Anticancer action of cube insecticide: correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities

Proceedings of the National Academy of Sciences - PNAS, 1998-03, Vol.95 (7), p.3380-3384

1998

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Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells

Deguelin targets multiple oncogenic signaling pathways to combat human malignancies

Pharmacological basis and new insights of deguelin concerning its anticancer effects

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury

Biopharmacological considerations for accelerating drug development of deguelin, a rotenoid with potent chemotherapeutic and chemopreventive potential

Regulation of the Endogenous Opiate Signaling Pathway against Oxidative Stress and Inflammation: A Considerable Approach for Exploring Preclinical Treatment of Parkinson’s Disease

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein

Neuroprotective effects of linagliptin in a rotenone-induced rat model of Parkinson's disease

Anticancer efficacy of deguelin in human prostate cancer cells targeting glycogen synthase kinase‐3 β/β‐catenin pathway

Tephrosin attenuates sepsis induced acute lung injury in rats by impeding expression of ICAM-1 and MIP-2

The Natural Rotenoid Deguelin Ameliorates Diabetic Neuropathy by Decreasing Oxidative Stress and Plasma Glucose Levels in Rats via the Nrf2 Signalling Pathway

The Role of the Akt/mTOR Pathway in Tobacco Carcinogen–Induced Lung Tumorigenesis

Rotenone restrains colon cancer cell viability, motility and epithelial‑mesenchymal transition and tumorigenesis in nude mice via the PI3K/AKT pathway

Millettia pachycarpa exhibits anti-inflammatory activity through the suppression of LPS-induced NO/iNOS expression

Deguelin Attenuates Allergic Airway Inflammation via Inhibition of NF-κb Pathway in Mice

Rotenone Remarkably Attenuates Oxidative Stress, Inflammation, and Fibrosis in Chronic Obstructive Uropathy

Deguelin, a Novel Anti-Tumorigenic Agent in Human Esophageal Squamous Cell Carcinoma

Role for pAKT in rat urinary bladder with cyclophosphamide (CYP)-induced cystitis

Antiangiogenic effect of deguelin on choroidal neovascularization

Deguelin and Its Role in Chronic Diseases

Deguelin, A PI3K/AKT inhibitor, enhances chemosensitivity of leukaemia cells with an active PI3K/AKT pathway

Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat

Evaluation of anti-bacterial and wound healing activity of the fruits of Amorpha fruticosa L

Efficacy of Deguelin and Silibinin on Benzo(a)pyrene-Induced Lung Tumorigenesis in A/J Mice

Anticancer action of cube insecticide: correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities

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