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Animal Models Are Valid to Uncover Disease Mechanisms

PLoS genetics, 2016-05, Vol.12 (5), p.e1006013-e1006013

2016

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Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

Nature biotechnology, 2015-05, Vol.33 (5), p.543-548

2015

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TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury

EMBO reports, 2017-07, Vol.18 (7), p.1186-1198

2017

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Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

Nature neuroscience, 2019-10, Vol.22 (10), p.1731

2019

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Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases

Proceedings of the National Academy of Sciences - PNAS, 2010-08, Vol.107 (34), p.15022-15026

2010

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Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

The EMBO journal, 2014-09, Vol.33 (18), p.2020-2039

2014

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The FTD‐like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism

The EMBO journal, 2017-07, Vol.36 (13), p.1837-1853

2017

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Genome editing for Duchenne muscular dystrophy: a glimpse of the future?

Gene therapy, 2021-09, Vol.28 (9), p.542-548

2021

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FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis

Neuron (Cambridge, Mass.), 2018-09, Vol.99 (6), p.1188-1203.e6

2018

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Genetic networks controlling the development of midbrain dopaminergic neurons

The Journal of physiology, 2006-09, Vol.575 (2), p.403-410

2006

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Rapamycin extends murine lifespan but has limited effects on aging

The Journal of clinical investigation, 2013-08, Vol.123 (8), p.3272-3291

2013

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Mutant non-coding RNA resource in mouse embryonic stem cells

Disease models & mechanisms, 2021-02, Vol.14 (2)

2021

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The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

Molecular neurodegeneration, 2018-09, Vol.13 (1), p.49-14, Article 49

2018

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Neural plate patterning: Upstream and downstream of the isthmic organizer

Nature reviews. Neuroscience, 2001-02, Vol.2 (2), p.99-108

2001

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Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides

Proceedings of the National Academy of Sciences - PNAS, 2013-03, Vol.110 (10), p.3782-3787

2013

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Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP

Nature neuroscience, 2010-12, Vol.13 (12), p.1481-1488

2010

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LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool

The Journal of neuroscience, 2011-02, Vol.31 (6), p.2225-2237

2011

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The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO

Molecular cell, 2013-03, Vol.49 (5), p.908-921

2013

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The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions

Molecular neurodegeneration, 2020-09, Vol.15 (1), p.1-52, Article 52

2020

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Glutamatergic and Dopaminergic Neurons Mediate Anxiogenic and Anxiolytic Effects of CRHR1

Science (American Association for the Advancement of Science), 2011-09, Vol.333 (6051), p.1903-1907

2011

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Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility

The Journal of biological chemistry, 2015-06, Vol.290 (23), p.14668-14678

2015

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Animal Models Are Valid to Uncover Disease Mechanisms

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

The FTD‐like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism

Genome editing for Duchenne muscular dystrophy: a glimpse of the future?

Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis

FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis

Genetic networks controlling the development of midbrain dopaminergic neurons

Rapamycin extends murine lifespan but has limited effects on aging

Mutant non-coding RNA resource in mouse embryonic stem cells

The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

Neural plate patterning: Upstream and downstream of the isthmic organizer

Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides

Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool

The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO

The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions

Glutamatergic and Dopaminergic Neurons Mediate Anxiogenic and Anxiolytic Effects of CRHR1

Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility

A protein quality control pathway regulated by linear ubiquitination

Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss

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