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Engineering strategies for rational polyketide synthase design

Natural product reports, 2018-10, Vol.35 (1), p.17-181

2018

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A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin

Nature communications, 2022-10, Vol.13 (1), p.6361-11, Article 6361

2022

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Structure and Mechanisms of Assembly-Line Polyketide Synthases

Annual review of biochemistry, 2024-08, Vol.93 (1), p.471-498

2024

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Unraveling the iterative type I polyketide synthases hidden in Streptomyces

Proceedings of the National Academy of Sciences - PNAS, 2020-04, Vol.117 (15), p.8449-8454

2020

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Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms

Nature chemical biology, 2015-09, Vol.11 (9), p.705-712

2015

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Automated structure prediction of trans-acyltransferase polyketide synthase products

Nature chemical biology, 2019-08, Vol.15 (8), p.813-821

2019

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The Structural Enzymology of Iterative Aromatic Polyketide Synthases: A Critical Comparison with Fatty Acid Synthases

Annual review of biochemistry, 2018-06, Vol.87 (1), p.503-531

Tsai, Shiou-Chuan (Sheryl)

2018

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Type II Polyketide Synthases: A Bioinformatics‐Driven Approach

Chembiochem : a European journal of chemical biology, 2023-05, Vol.24 (9), p.e202200775-n/a

2023

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Transcriptomic analysis of polyketide synthesis in dinoflagellate, Prorocentrum lima

Harmful algae, 2023-03, Vol.123, p.102391-102391, Article 102391

2023

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Structural insights into type III polyketide synthase CylI from cylindrocyclophane biosynthesis

Protein science, 2024-10, Vol.33 (10), p.e5130-n/a

2024

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Polyketide Synthase Modules Redefined

Angewandte Chemie International Edition, 2017-04, Vol.56 (17), p.4658-4660

Keatinge‐Clay, Adrian T.

International ed. in English, 2017

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Insights into modular polyketide synthase loops aided by repetitive sequences

Proteins, structure, function, and bioinformatics, 2021-09, Vol.89 (9), p.1099-1110

2021

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A discrete intermediate for the biosynthesis of both the enediyne core and the anthraquinone moiety of enediyne natural products

Proceedings of the National Academy of Sciences - PNAS, 2023-02, Vol.120 (9), p.e2220468120-e2220468120

2023

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Genetic Mapping and Biochemical Basis of Yellow Feather Pigmentation in Budgerigars

Cell, 2017-10, Vol.171 (2), p.427-439.e21

2017

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Chemistry of a Unique Polyketide-like Synthase

Journal of the American Chemical Society, 2018-02, Vol.140 (7), p.2430-2433

2018

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Structure of a modular polyketide synthase

Nature (London), 2014-06, Vol.510 (7506), p.512-517

2014

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Modular polyketide synthase contains two reaction chambers that operate asynchronously

Science (American Association for the Advancement of Science), 2021-11, Vol.374 (6568), p.723-729

2021

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Loss of Single‐Domain Function in a Modular Assembly Line Alters the Size and Shape of a Complex Polyketide

Angewandte Chemie International Edition, 2019-12, Vol.58 (50), p.18252-18256

International ed. in English, 2019

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Giant polyketide synthase enzymes in the biosynthesis of giant marine polyether toxins

Science (American Association for the Advancement of Science), 2024-08, Vol.385 (6709), p.671-678

2024

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Structure of the Cannabis sativa olivetol‐producing enzyme reveals cyclization plasticity in type III polyketide synthases

The FEBS journal, 2020-04, Vol.287 (8), p.1511-1524

2020

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Genome mining and biosynthesis of a polyketide from a biofertilizer fungus that can facilitate reductive iron assimilation in plant

Proceedings of the National Academy of Sciences - PNAS, 2019-03, Vol.116 (12), p.5499-5504

2019

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Architectures of Whole-Module and Bimodular Proteins from the 6-Deoxyerythronolide B Synthase

Journal of molecular biology, 2014-05, Vol.426 (11), p.2229-2245

2014

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Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase

Journal of molecular biology, 2008-12, Vol.384 (4), p.941-953

Keatinge-Clay, Adrian

2008

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Structural basis for selectivity in a highly reducing type II polyketide synthase

Nature chemical biology, 2020-07, Vol.16 (7), p.776-782

2020

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Structural snapshots of the minimal PKS system responsible for octaketide biosynthesis

Nature chemistry, 2020-08, Vol.12 (8), p.755-763

2020

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Engineering strategies for rational polyketide synthase design

A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin

Structure and Mechanisms of Assembly-Line Polyketide Synthases

Unraveling the iterative type I polyketide synthases hidden in Streptomyces

Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms

Automated structure prediction of trans-acyltransferase polyketide synthase products

The Structural Enzymology of Iterative Aromatic Polyketide Synthases: A Critical Comparison with Fatty Acid Synthases

Type II Polyketide Synthases: A Bioinformatics‐Driven Approach

Transcriptomic analysis of polyketide synthesis in dinoflagellate, Prorocentrum lima

Structural insights into type III polyketide synthase CylI from cylindrocyclophane biosynthesis

Polyketide Synthase Modules Redefined

Insights into modular polyketide synthase loops aided by repetitive sequences

A discrete intermediate for the biosynthesis of both the enediyne core and the anthraquinone moiety of enediyne natural products

Genetic Mapping and Biochemical Basis of Yellow Feather Pigmentation in Budgerigars

Chemistry of a Unique Polyketide-like Synthase

Structure of a modular polyketide synthase

Modular polyketide synthase contains two reaction chambers that operate asynchronously

Loss of Single‐Domain Function in a Modular Assembly Line Alters the Size and Shape of a Complex Polyketide

Giant polyketide synthase enzymes in the biosynthesis of giant marine polyether toxins

Structure of the Cannabis sativa olivetol‐producing enzyme reveals cyclization plasticity in type III polyketide synthases

Genome mining and biosynthesis of a polyketide from a biofertilizer fungus that can facilitate reductive iron assimilation in plant

Architectures of Whole-Module and Bimodular Proteins from the 6-Deoxyerythronolide B Synthase

Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase

Structural basis for selectivity in a highly reducing type II polyketide synthase

Structural snapshots of the minimal PKS system responsible for octaketide biosynthesis

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