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A Pitx3-deficient developmental mouse model for fine motor, olfactory, and gastrointestinal symptoms of Parkinson's disease

Neurobiology of disease, 2022-08, Vol.170, p.105777-105777, Article 105777

2022

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Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson’s Disease

Cell stem cell, 2020-04, Vol.26 (4), p.511-526.e5

2020

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A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells

Cell stem cell, 2022-03, Vol.29 (3), p.434-448.e5

2022

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Unilateral buphthalmos, corneal staphyloma and corneal fistula caused by pathogenic variant in the PITX3 gene: a case report

BMC ophthalmology, 2022-09, Vol.22 (1), p.1-385, Article 385

2022

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Structural insights into the recognition of the A/T-rich motif in target gene promoters by the LMX1a homeobox domain

The FEBS journal, 2024-07, Vol.291 (13), p.2792-2810

2024

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Bioluminescence‐driven optogenetic activation of transplanted neural precursor cells improves motor deficits in a Parkinson's disease mouse model

Journal of neuroscience research, 2020-03, Vol.98 (3), p.458-468

2020

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Isolation of LMX1a Ventral Midbrain Progenitors Improves the Safety and Predictability of Human Pluripotent Stem Cell-Derived Neural Transplants in Parkinsonian Disease

The Journal of neuroscience, 2019-11, Vol.39 (48), p.9521-9531

2019

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Development and function of the midbrain dopamine system: what we know and what we need to

Genes, brain and behavior, 2016-01, Vol.15 (1), p.62-73

2016

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Mice hypomorphic for Pitx3 show robust entrainment of circadian behavioral and metabolic rhythms to scheduled feeding

Cell reports (Cambridge), 2022-01, Vol.38 (2), p.109865-109865, Article 109865

2022

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Dysregulation of Dopaminergic Regulatory Factors TH, Nurr1, and Pitx3 in the Ventral Tegmental Area Associated with Neuronal Injury Induced by Chronic Morphine Dependence

International journal of molecular sciences, 2019-01, Vol.20 (2), p.250

2019

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Restricting feeding to dark phase fails to entrain circadian activity and energy expenditure oscillations in Pitx3-mutant Aphakia mice

Cell reports (Cambridge), 2022-01, Vol.38 (2), p.110241-110241, Article 110241

2022

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A novel mutation in the OAR domain of PITX3 associated with congenital posterior subcapsular cataract

BMC medical genetics, 2019-03, Vol.20 (1), p.42-42, Article 42

2019

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First evidence of SOX2 mutations in Peters' anomaly: Lessons from molecular screening of 95 patients

Clinical genetics, 2022-05, Vol.101 (5-6), p.494-506

2022

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Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells

Proceedings of the National Academy of Sciences - PNAS, 2013-02, Vol.110 (7), p.E602-E610

2013

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The essential role of transcription factor Pitx3 in preventing mesodiencephalic dopaminergic neurodegeneration and maintaining neuronal subtype identities during aging

Cell death & disease, 2021-10, Vol.12 (11), p.1008-1008, Article 1008

2021

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Epigenetic Regulation of the Ontogenic Expression of the Dopamine Transporter

Frontiers in genetics, 2019-11, Vol.10, p.1099

2019

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The Crucial Roles of Pitx3 in Midbrain Dopaminergic Neuron Development and Parkinson's Disease-Associated Neurodegeneration

International journal of molecular sciences, 2023-05, Vol.24 (10), p.8614

2023

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Nitric oxide synthase inhibition decreases l- DOPA-induced dyskinesia and the expression of striatal molecular markers in Pitx3−/− aphakia mice

Neurobiology of disease, 2015-01, Vol.73, p.49-59

2015

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Molecular mechanisms of dopaminergic subset specification: fundamental aspects and clinical perspectives

Cellular and molecular life sciences : CMLS, 2014-12, Vol.71 (24), p.4703-4727

2014

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Human Mesenchymal Stromal Cells Unveil an Unexpected Differentiation Potential toward the Dopaminergic Neuronal Lineage

International journal of molecular sciences, 2020-09, Vol.21 (18), p.6589

2020

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The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson’s disease

Brain (London, England : 1878), 2010-02, Vol.133 (2), p.482-495

2010

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Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1

Neuropharmacology, 2017-10, Vol.125, p.189-196

2017

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Time course and side‐by‐side analysis of mesodermal, pre‐myogenic, myogenic and differentiated cell markers in the chicken model for skeletal muscle formation

Journal of anatomy, 2015-09, Vol.227 (3), p.361-382

2015

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Carbon Fibers as a New Type of Scaffold for Midbrain Organoid Development

International journal of molecular sciences, 2020-08, Vol.21 (17), p.5959

2020

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From eyeless to neurological diseases

Experimental eye research, 2017-03, Vol.156, p.5-9

Graw, Jochen

2017

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A Pitx3-deficient developmental mouse model for fine motor, olfactory, and gastrointestinal symptoms of Parkinson's disease

Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson’s Disease

A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells

Unilateral buphthalmos, corneal staphyloma and corneal fistula caused by pathogenic variant in the PITX3 gene: a case report

Structural insights into the recognition of the A/T-rich motif in target gene promoters by the LMX1a homeobox domain

Bioluminescence‐driven optogenetic activation of transplanted neural precursor cells improves motor deficits in a Parkinson's disease mouse model

Isolation of LMX1a Ventral Midbrain Progenitors Improves the Safety and Predictability of Human Pluripotent Stem Cell-Derived Neural Transplants in Parkinsonian Disease

Development and function of the midbrain dopamine system: what we know and what we need to

Mice hypomorphic for Pitx3 show robust entrainment of circadian behavioral and metabolic rhythms to scheduled feeding

Dysregulation of Dopaminergic Regulatory Factors TH, Nurr1, and Pitx3 in the Ventral Tegmental Area Associated with Neuronal Injury Induced by Chronic Morphine Dependence

Restricting feeding to dark phase fails to entrain circadian activity and energy expenditure oscillations in Pitx3-mutant Aphakia mice

A novel mutation in the OAR domain of PITX3 associated with congenital posterior subcapsular cataract

First evidence of SOX2 mutations in Peters' anomaly: Lessons from molecular screening of 95 patients

Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells

The essential role of transcription factor Pitx3 in preventing mesodiencephalic dopaminergic neurodegeneration and maintaining neuronal subtype identities during aging

Epigenetic Regulation of the Ontogenic Expression of the Dopamine Transporter

The Crucial Roles of Pitx3 in Midbrain Dopaminergic Neuron Development and Parkinson's Disease-Associated Neurodegeneration

Nitric oxide synthase inhibition decreases l- DOPA-induced dyskinesia and the expression of striatal molecular markers in Pitx3−/− aphakia mice

Molecular mechanisms of dopaminergic subset specification: fundamental aspects and clinical perspectives

Human Mesenchymal Stromal Cells Unveil an Unexpected Differentiation Potential toward the Dopaminergic Neuronal Lineage

The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson’s disease

Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1

Time course and side‐by‐side analysis of mesodermal, pre‐myogenic, myogenic and differentiated cell markers in the chicken model for skeletal muscle formation

Carbon Fibers as a New Type of Scaffold for Midbrain Organoid Development

From eyeless to neurological diseases

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