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Correction for Latoscha et al., c-di-AMP hydrolysis by the phosphodiesterase AtaC promotes differentiation of multicellular bacteria

Proceedings of the National Academy of Sciences - PNAS, 2020-09, Vol.117 (35), p.21824-21824

2020

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New imidazopyridines with phosphodiesterase 4 and 7 inhibitory activity and their efficacy in animal models of inflammatory and autoimmune diseases

European journal of medicinal chemistry, 2021-01, Vol.209, p.112854, Article 112854

2021

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Clinical Implication of Phosphodiesterase-4-Inhibition

International journal of molecular sciences, 2022-01, Vol.23 (3), p.1209

2022

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Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

Nature (London), 2015-03, Vol.519 (7544), p.472-476

2015

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Selective PDE inhibitors as novel treatments for respiratory diseases

Current opinion in pharmacology, 2012-06, Vol.12 (3), p.275-286

2012

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Phosphodiestrase-1 and 4 inhibitors ameliorate liver fibrosis in rats: Modulation of cAMP/CREB/TLR4 inflammatory and fibrogenic pathways

Life sciences (1973), 2019-04, Vol.222, p.245-254

2019

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The NO/cGMP/PKG pathway in platelets: The therapeutic potential of PDE5 inhibitors in platelet disorders

Journal of thrombosis and haemostasis, 2022-11, Vol.20 (11), p.2465-2474

2022

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Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain

European journal of medicinal chemistry, 2018-10, Vol.158, p.517-533

2018

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Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF

Oncogene, 2013-02, Vol.32 (9), p.1121-1134

2013

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Trial of a Preferential Phosphodiesterase 4B Inhibitor for Idiopathic Pulmonary Fibrosis

The New England journal of medicine, 2022-06, Vol.386 (23), p.2178-2187

2022

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Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

Nature biotechnology, 2010-01, Vol.28 (1), p.63-70

2010

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Phosphodiesterase inhibitors in airways disease

European journal of pharmacology, 2006-03, Vol.533 (1-3), p.110-117

Fan Chung, Kian

2006

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Gap Junction Structure and Chemical Regulation: Direct Calmodulin Role in Cell-to-Cell Channel Gating

Peracchia, Camillo

1, 2019

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Advances in the Development of Phosphodiesterase‑4 Inhibitors

Journal of medicinal chemistry, 2020-10, Vol.63 (19), p.10594-10617

2020

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Effect of Roflumilast Cream vs Vehicle Cream on Chronic Plaque Psoriasis: The DERMIS-1 and DERMIS-2 Randomized Clinical Trials

JAMA : the journal of the American Medical Association, 2022-09, Vol.328 (11), p.1073

2022

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Phosphodiesterase inhibitors

British journal of pharmacology, 2006-01, Vol.147 (S1), p.S252-S257

2006

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Design, Synthesis, and Evaluation of Dihydropyrimidine Derivatives as Selective PDE1 Inhibitors for the Treatment of Liver Fibrosis

Journal of medicinal chemistry, 2024-05, Vol.67 (10), p.8309-8322

2024

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Phosphodiesterase 4 Inhibitor Therapies for Atopic Dermatitis: Progress and Outlook

Drugs (New York, N.Y.), 2017-09, Vol.77 (13), p.1389-1397

2017

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Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy

Journal of medicinal chemistry, 2009-12, Vol.52 (24), p.7946-7949

2009

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Phosphodiesterase 5 (PDE5): Structure-function regulation and therapeutic applications of inhibitors

Biomedicine & pharmacotherapy, 2021-02, Vol.134, p.111128, Article 111128

2021

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Role of Phosphodiesterase 7 (PDE7) in T Cell Activity. Effects of Selective PDE7 Inhibitors and Dual PDE4/7 Inhibitors on T Cell Functions

International journal of molecular sciences, 2020-08, Vol.21 (17), p.6118

Szczypka, Marianna

2020

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Distinct patterns of constitutive phosphodiesterase activity in mouse sinoatrial node and atrial myocardium

PloS one, 2012-10, Vol.7 (10), p.e47652-e47652

2012

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Allosteric inhibition of phosphodiesterase 4D induces biphasic memory-enhancing effects associated with learning-activated signaling pathways

Psychopharmacology, 2024-04, Vol.241 (4), p.805-816

2024

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Phosphodiesterase isoform-specific expression induced by traumatic brain injury

Journal of neurochemistry, 2012-12, Vol.123 (6), p.1019-1029

2012

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Discovery of Evodiamine Derivatives as Highly Selective PDE5 Inhibitors Targeting a Unique Allosteric Pocket

Journal of medicinal chemistry, 2020-09, Vol.63 (17), p.9828-9837

2020

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