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Randomized, phase 2 trial of low-dose cytarabine with or without volasertib in AML patients not suitable for induction therapy

Blood, 2014-08, Vol.124 (9), p.1426-1433

2014

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Design, synthesis, and biological evaluation of 4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine derivatives as novel dual-PLK1/BRD4 inhibitors

European journal of medicinal chemistry, 2020-04, Vol.191, p.112152, Article 112152

2020

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Identification and Optimization of Pteridinone Toll-like Receptor 7 (TLR7) Agonists for the Oral Treatment of Viral Hepatitis

Journal of medicinal chemistry, 2013-09, Vol.56 (18), p.7324-7333

2013

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A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma

EBioMedicine, 2019-03, Vol.41, p.244-255

2019

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A phase I study of two dosing schedules of volasertib (BI 6727), an intravenous polo-like kinase inhibitor, in patients with advanced solid malignancies

British journal of cancer, 2014-05, Vol.110 (10), p.2434-2440

2014

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Current clinical trials with polo-like kinase 1 inhibitors in solid tumors

Anti-cancer drugs, 2013-11, Vol.24 (10), p.999-1006

Yim, Hyungshin

2013

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Spotlight on Volasertib: Preclinical and Clinical Evaluation of a Promising Plk1 Inhibitor

Medicinal research reviews, 2016-07, Vol.36 (4), p.749-786

2016

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GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees

Gastroenterology (New York, N.Y. 1943), 2013-06, Vol.144 (7), p.1508-1517.e10

2013

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Discovery of Pteridine-7(8H)‑one Derivatives as Potent and Selective Inhibitors of Bruton’s Tyrosine Kinase (BTK)

Journal of medicinal chemistry, 2022-02, Vol.65 (3), p.2694-2709

2022

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BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity

Clinical cancer research, 2009-05, Vol.15 (9), p.3094-3102

2009

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Pharmacokinetic and pharmacodynamic properties of GS-9620, a novel Toll-like receptor 7 agonist, demonstrate interferon-stimulated gene induction without detectable serum interferon at low oral doses

The Journal of pharmacology and experimental therapeutics, 2014-01, Vol.348 (1), p.96

2014

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Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B

Journal of hepatology, 2015-06, Vol.62 (6), p.1237-1245

2015

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The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection

Journal of hepatology, 2015-08, Vol.63 (2), p.320-328

2015

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Identification and age-dependence of pteridines in bed bugs (Cimex lectularius) and bat bugs (C. pipistrelli) using liquid chromatography-tandem mass spectrometry

Scientific reports, 2020-06, Vol.10 (1), p.10146, Article 10146

2020

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Self-assembling purine and pteridine quartets: how do π-conjugation patterns affect resonance-assisted hydrogen bonding?

Organic & biomolecular chemistry, 2020-02, Vol.18 (6), p.178-181

2020

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Synthesis and Structure–Activity Relationships of Pteridine Dione and Trione Monocarboxylate Transporter 1 Inhibitors

Journal of medicinal chemistry, 2014-09, Vol.57 (17), p.7317-7324

2014

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Structure-based design and SAR development of novel selective polo-like kinase 1 inhibitors having the tetrahydropteridin scaffold

European journal of medicinal chemistry, 2019-12, Vol.184, p.111769, Article 111769

2019

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Cooption of the pteridine biosynthesis pathway underlies the diversification of embryonic colors in water striders

Proceedings of the National Academy of Sciences - PNAS, 2019-09, Vol.116 (38), p.19046-19054

2019

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Sulfamethoxazole drug stress upregulates antioxidant immunomodulatory metabolites in Escherichia coli

Nature microbiology, 2020-11, Vol.5 (11), p.1319

2020

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Design, synthesis and biological evaluation of novel pteridinone derivatives possessing a hydrazone moiety as potent PLK1 inhibitors

Bioorganic & medicinal chemistry letters, 2020-08, Vol.30 (16), p.127329-127329, Article 127329

2020

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Sorafenib-loaded hydroxyethyl starch-TG100-115 micelles for the treatment of liver cancer based on synergistic treatment

Drug delivery, 2019-01, Vol.26 (1), p.756-764

2019

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Тhio‐containing pteridines: Synthesis, modification, and biological activity

Archiv der Pharmazie (Weinheim), 2022-12, Vol.355 (12), p.n/a

2022

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The effect of MR1 ligand glyco-analogues on mucosal-associated invariant T (MAIT) cell activation

Organic & biomolecular chemistry, 2019-10, Vol.17 (4), p.8992-9

2019

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Substituted pteridinones as p90 ribosomal S6 protein kinase (RSK) inhibitors: A structure-activity study

Bioorganic & medicinal chemistry, 2020-03, Vol.28 (5), p.115303, Article 115303

2020

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Age-dependent changes in cuticular color and pteridine levels in a clonal ant

Journal of insect physiology, 2019-10, Vol.118, p.103943-103943, Article 103943

2019

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1 – 25 von 3.485

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Randomized, phase 2 trial of low-dose cytarabine with or without volasertib in AML patients not suitable for induction therapy

Design, synthesis, and biological evaluation of 4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine derivatives as novel dual-PLK1/BRD4 inhibitors

Identification and Optimization of Pteridinone Toll-like Receptor 7 (TLR7) Agonists for the Oral Treatment of Viral Hepatitis

A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma

A phase I study of two dosing schedules of volasertib (BI 6727), an intravenous polo-like kinase inhibitor, in patients with advanced solid malignancies

Current clinical trials with polo-like kinase 1 inhibitors in solid tumors

Spotlight on Volasertib: Preclinical and Clinical Evaluation of a Promising Plk1 Inhibitor

GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees

Discovery of Pteridine-7(8H)‑one Derivatives as Potent and Selective Inhibitors of Bruton’s Tyrosine Kinase (BTK)

BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity

Pharmacokinetic and pharmacodynamic properties of GS-9620, a novel Toll-like receptor 7 agonist, demonstrate interferon-stimulated gene induction without detectable serum interferon at low oral doses

Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B

The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection

Identification and age-dependence of pteridines in bed bugs (Cimex lectularius) and bat bugs (C. pipistrelli) using liquid chromatography-tandem mass spectrometry

Self-assembling purine and pteridine quartets: how do π-conjugation patterns affect resonance-assisted hydrogen bonding?

Synthesis and Structure–Activity Relationships of Pteridine Dione and Trione Monocarboxylate Transporter 1 Inhibitors

Structure-based design and SAR development of novel selective polo-like kinase 1 inhibitors having the tetrahydropteridin scaffold

Cooption of the pteridine biosynthesis pathway underlies the diversification of embryonic colors in water striders

Sulfamethoxazole drug stress upregulates antioxidant immunomodulatory metabolites in Escherichia coli

Design, synthesis and biological evaluation of novel pteridinone derivatives possessing a hydrazone moiety as potent PLK1 inhibitors

Sorafenib-loaded hydroxyethyl starch-TG100-115 micelles for the treatment of liver cancer based on synergistic treatment

Тhio‐containing pteridines: Synthesis, modification, and biological activity

The effect of MR1 ligand glyco-analogues on mucosal-associated invariant T (MAIT) cell activation

Substituted pteridinones as p90 ribosomal S6 protein kinase (RSK) inhibitors: A structure-activity study

Age-dependent changes in cuticular color and pteridine levels in a clonal ant

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